VPS10_ASPCL
ID VPS10_ASPCL Reviewed; 1486 AA.
AC A1C8D8;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 25-MAY-2022, entry version 68.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10;
DE AltName: Full=Carboxypeptidase Y receptor;
DE Short=CPY receptor;
DE AltName: Full=Sortilin vps10;
DE AltName: Full=Vacuolar carboxypeptidase sorting receptor vps10;
DE Flags: Precursor;
GN Name=vps10; ORFNames=ACLA_042930;
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Prevacuolar
CC compartment membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250}. Note=Cycles between the Golgi apparatus and the
CC prevacuolar compartment. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC {ECO:0000305}.
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DR EMBL; DS027046; EAW13575.1; -; Genomic_DNA.
DR RefSeq; XP_001275001.1; XM_001275000.1.
DR AlphaFoldDB; A1C8D8; -.
DR SMR; A1C8D8; -.
DR STRING; 5057.CADACLAP00004043; -.
DR EnsemblFungi; EAW13575; EAW13575; ACLA_042930.
DR GeneID; 4707265; -.
DR KEGG; act:ACLA_042930; -.
DR VEuPathDB; FungiDB:ACLA_042930; -.
DR eggNOG; KOG3511; Eukaryota.
DR HOGENOM; CLU_000700_0_0_1; -.
DR OMA; ATMSEFI; -.
DR OrthoDB; 1046610at2759; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
PE 3: Inferred from homology;
KW Glycoprotein; Golgi apparatus; Membrane; Protein transport; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..1486
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /id="PRO_0000407503"
FT TOPO_DOM 24..1349
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 1350..1370
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1371..1405
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 1406..1426
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1427..1486
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT REPEAT 61..71
FT /note="BNR 1"
FT REPEAT 378..387
FT /note="BNR 2"
FT REPEAT 438..448
FT /note="BNR 3"
FT REPEAT 480..489
FT /note="BNR 4"
FT REPEAT 719..729
FT /note="BNR 5"
FT REPEAT 1102..1112
FT /note="BNR 6"
FT REPEAT 1144..1153
FT /note="BNR 7"
FT CARBOHYD 300
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 324
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 965
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1263
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1486 AA; 166554 MW; EC824BC1BC4CF241 CRC64;
MISRWLLLIG LLALALFSQP CATEKAEPQI NSTPFDHEPF FMSYFEDSDT ILMLTTQRNL
FRSFDGGKGW ERVDDMDGKM KQHVVSVLQH PSDKDKAYAL GSKGRHWITT DRAKTWNAFT
IHQSPAIQHE PLVFHGWDSG KVIFQTDECI GTFCIVKSYY TTDDFKTVSP LRVSAGGCAW
AVGHPQFAEG LNLEDQIRNR VLCVVSGLKV PAPYANRLVY SDDFFSNEAD GAEMNLHQGR
PVSGVQTTAA VKKFLVAAVK SQGTDEMALY VTLDTKVWHR ADFGGHRVEQ DAYTVLESTN
YSMQVDVLTD QSSMTGVLFT SNSNGTYFTR NVEHTNRDRF GHVDFEKIAD IQGIVLVNTV
SNWKKLESDH RKKIVSEVSF DDGRTFQPLT VGDKHLHLHS VTTYANTGRV FSSPAPGVVM
GVGNKGDHLK EYSECDLYVS DDAGVTWRHA LDGPFKYEFG DQGAIIMAVS DKGKIGEIKY
STDHGKEWHT AKLQHEIFPK MLTTTPDSTS MKFVLVGSKE STGDGFFVYS IDFGSLHGRK
CEKDDFEKWP ARLNEDGEPD CLMGHKQFFN RRKANADCFM DEEFKDPQPI FEPCKCTAED
YECDYNFVRS EDGKSCLPAA PLVPPAGKCR EKTDKFYGPS GWRLIPGNNC IREGGENLDK
DIERTCEDTN GSPETHMSHK QVFDNSKQFS GQYFYLERQA SSSGNDETVL MLTREREFWV
SHDHGKKWEQ PLKGVQIVAI IPHPYYSDGA FLLTGGQEAF WTVDRAYTFK SFKVPIPPTR
DDMPVFSFHP QYKDWLIWTG AVDCGHGDCH SDAYITKNRG KDWDLLLRYV GKCEFESRKN
RPDSENLIFC EQYANENKNN HKQLLSSDSF FADSHVHFDN EARYATMSEY IIVASHDPNN
ANSLIASVSV DGKTFAEAKF PPNVDVPVKT AFTVLDSSTH AVFLHLTMGV LKGAEYGSII
KSNSNGTLYT VSLNAASRDD RGFVDYEKMQ GLEGVAVANV ISNVDTVLKK GAAAKKVKTK
ITHNDGGQWM LLPPPAKDAE GKDFGCSNKD GKASDKCSLH LHGYTERWDS RDTFSSGSAI
GLMMGVGNVG DHLTSKEEAD TFMTRDGGIT WKPIKKGRYI WEYGDSGSVI VIVPESRPTK
ILHYSLDEGD SWENFKFSDV DMLIHRLSTL PSDTSKNFLL WGKEQDSNQL ATVNVDFSSL
REASCKLVED GQDSDDYYLW EPKHPLQEDN CLFGHIEQYH RKKLAANCWN NWREPHVHSI
GKNCTCTRAD YECDYNYEPQ SDGSCALVPG LPKPDASIVC KEDPDKIEYP ELLLGYRRIP
QTTCMGGWEP PVVFKPCPGK EKEYKKKHSI SGIGLFFAIV TPIAMASAAG YYVYTRWDGK
FGQIRLGEDI GGREAILSRD SPLVAVPIAI IAGVVAVLKA LPLLAISLWR SSSSFIRTRR
DRAYSRPYAS RGSFAARRGD YTSVVDDEDE LLGVEDGEAE GEEEEL
