VPS10_ASPFU
ID VPS10_ASPFU Reviewed; 1487 AA.
AC Q4WBM1;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10;
DE AltName: Full=Carboxypeptidase Y receptor;
DE Short=CPY receptor;
DE AltName: Full=Sortilin vps10;
DE AltName: Full=Vacuolar carboxypeptidase sorting receptor vps10;
DE Flags: Precursor;
GN Name=vps10; ORFNames=AFUA_8G02780;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Prevacuolar
CC compartment membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250}. Note=Cycles between the Golgi apparatus and the
CC prevacuolar compartment. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC {ECO:0000305}.
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DR EMBL; AAHF01000014; EAL84891.1; -; Genomic_DNA.
DR RefSeq; XP_746929.1; XM_741836.1.
DR AlphaFoldDB; Q4WBM1; -.
DR SMR; Q4WBM1; -.
DR STRING; 746128.CADAFUBP00008158; -.
DR EnsemblFungi; EAL84891; EAL84891; AFUA_8G02780.
DR GeneID; 3504431; -.
DR KEGG; afm:AFUA_8G02780; -.
DR VEuPathDB; FungiDB:Afu8g02780; -.
DR eggNOG; KOG3511; Eukaryota.
DR HOGENOM; CLU_000700_0_0_1; -.
DR InParanoid; Q4WBM1; -.
DR OMA; ATMSEFI; -.
DR OrthoDB; 1046610at2759; -.
DR Proteomes; UP000002530; Chromosome 8.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0006895; P:Golgi to endosome transport; IBA:GO_Central.
DR GO; GO:0006896; P:Golgi to vacuole transport; IBA:GO_Central.
DR GO; GO:0006892; P:post-Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
DR SUPFAM; SSF50939; SSF50939; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Golgi apparatus; Membrane; Protein transport; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..1487
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /id="PRO_0000407506"
FT TOPO_DOM 23..1356
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 1357..1377
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1378..1409
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 1410..1430
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1431..1487
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT REPEAT 61..71
FT /note="BNR 1"
FT REPEAT 378..387
FT /note="BNR 2"
FT REPEAT 438..448
FT /note="BNR 3"
FT REPEAT 479..489
FT /note="BNR 4"
FT REPEAT 721..731
FT /note="BNR 5"
FT REPEAT 816..826
FT /note="BNR 6"
FT REPEAT 1104..1114
FT /note="BNR 7"
FT REPEAT 1145..1155
FT /note="BNR 8"
FT CARBOHYD 300
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 324
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 967
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1265
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1487 AA; 166459 MW; B89476E2092F5D29 CRC64;
MITRWLLITS FLALAILSLS SAAKKSEPEI TSSSFDNEPF SLSYFEDTET ILMNTRDGNL
FRSFDGGKAW EQVDGPDGKM KKAVRSIWQH PFDKNKAYAL GANRRHWVTK DQAKTWESFE
VDGYAAAQHE PLIFHGWDSA KVIFQSDECM GRLCIVKSYY TTDDFKTVSP LRVSAGGCLW
AVGHPQFADG LNLEDELRDR VLCIVPGLKV PSAHANRLVY SDDFFRSDAE GTELNIQHGR
PVSGILSAAA VKKFFVTAAK SQGTNELALY VTLDTKAWHR ADFGGHRVEQ DGYTLLESTN
YSMQVDVLTS PSSNTGVLFT SNSNGTYFTR NVEHTNRDRF GHVDFEKIAD IQGIVLVNTV
KNWDKVESEN EKKVVSSISF DDGRTFQSLK VGDKQLHLHS VTTFANTGRV FSSPAPGLVM
GVGNTGDHLK KYSEGSLYVS DDAGVTWRHA LDGPFKYEFG DQGSVIMAVS DKGTTDEIQF
SIDHGKEWHS TKLQHKINPK LLTTTPDSTS LTFLLVGSEE SSGTKHVVYS IDFHGLHERK
CEKDDFEKWA ARLNENGEPD CLMGHQQFFN RRKANADCFV DEEFKDPQPI FEPCKCSFED
FECDFNFVRS EDGKSCVPTA PLVPPVGRCQ KQTDTFMGPS GWRLIPGNTC TREGGENLDK
VVERPCKDVV SAPSHDKPMA QKQVFNDARQ FSEQYYYLER QASSSGDDET VIMLTSEGEF
WVSHDHGKNW EQPLKGVKIA AIVPHPYYSD GAFLLTRDKQ AFWTVDRAYT FKSFEAPIPP
NQEGLPVLSF HPHYKDWLIW TGAVDCSHGD CHSDAYFSKN RGENWDLLLR YVGKCEFESR
ENRPGSEKLI FCQQYENENK KNHLQLLSSE NLFSDSHVHF NDAIRYATMS EYIIVASRDP
DNPDSLIASV SVDGKTFARA EFPSNVDVPV KTAFTVLDSS THAVFLHVTV SDVKGAEYGS
IIKSNSNGTS YVLSLNAASR NEWGYVDFEK MQGLEGVAVV NIISNVDAVQ KKGPAAKKLK
TMITHNDGGQ WMLLPPPAKD ADGKNFGCSV KDGKGSDQCS LHLHGYTERR DPRDTFSSGS
AIGLMMGIGN VGAYLSGKDE ADTFMTRDGG ITWKSVKKGR YMWEYGDAGS VIVIVPELRP
TKVLYYSLDE GDNWEPYEFS EVEMHIYRLS TVPSDTSKNF LLWGKEMESN RLATINVDFS
GLRKKSCILV EDGQESDDYY LWEPKHPFQE DNCLFGHVEQ YHRKKPSSQC WNNWREPHVH
SIGRNCTCTR ADYECNYNYE PQNDGSCALV PGLPKPDALA VCREDPDRVE YWEPTAYRRI
PQTTCSGGLI LDHVVSKPCP SKEKEYEKKH GISGTGLFFA IMIPLVAAAG VGYYVYARWD
GKFGQIRLGE NAGTYEGLLS RESPIVTAPI AIIAGIVAVI RALPLLAMSL WRSASGYVRL
GRNRAYSRPY ASRGSFAARR GDYTSVVDDE DELLGVDDAE IDDDDEL
