VPS10_ASPNC
ID VPS10_ASPNC Reviewed; 1472 AA.
AC A2QHH4;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2007, sequence version 1.
DT 25-MAY-2022, entry version 66.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10;
DE AltName: Full=Carboxypeptidase Y receptor;
DE Short=CPY receptor;
DE AltName: Full=Sortilin vps10;
DE AltName: Full=Vacuolar carboxypeptidase sorting receptor vps10;
DE Flags: Precursor;
GN Name=vps10; ORFNames=An03g06880;
OS Aspergillus niger (strain CBS 513.88 / FGSC A1513).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=425011;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 513.88 / FGSC A1513 / ATCC MYA-4892;
RX PubMed=17259976; DOI=10.1038/nbt1282;
RA Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X.,
RA Contreras R., Cornell M., Coutinho P.M., Danchin E.G.J., Debets A.J.M.,
RA Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M.,
RA d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J.,
RA Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W.,
RA van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M.,
RA Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A.,
RA Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E.,
RA Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J.,
RA Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H.,
RA Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.;
RT "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT niger CBS 513.88.";
RL Nat. Biotechnol. 25:221-231(2007).
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Prevacuolar
CC compartment membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250}. Note=Cycles between the Golgi apparatus and the
CC prevacuolar compartment. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC {ECO:0000305}.
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DR EMBL; AM270061; CAK38444.1; -; Genomic_DNA.
DR AlphaFoldDB; A2QHH4; -.
DR SMR; A2QHH4; -.
DR PaxDb; A2QHH4; -.
DR PRIDE; A2QHH4; -.
DR EnsemblFungi; CAK38444; CAK38444; An03g06880.
DR HOGENOM; CLU_000700_0_0_1; -.
DR Proteomes; UP000006706; Chromosome 6R.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
PE 3: Inferred from homology;
KW Glycoprotein; Golgi apparatus; Membrane; Protein transport; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..1472
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /id="PRO_5000219828"
FT TOPO_DOM 24..1335
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 1336..1356
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1357..1388
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 1389..1409
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1410..1472
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT REPEAT 64..72
FT /note="BNR 1"
FT REPEAT 369..378
FT /note="BNR 2"
FT REPEAT 429..439
FT /note="BNR 3"
FT REPEAT 706..716
FT /note="BNR 4"
FT REPEAT 801..811
FT /note="BNR 5"
FT REPEAT 1127..1136
FT /note="BNR 6"
FT CARBOHYD 291
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 315
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 952
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1472 AA; 164084 MW; 365BE0A43054DF82 CRC64;
MIFRWLLLVS CLLVALIPQQ SSAKKSDQPK VTATKLEHEP FSLFYFEDSE TVLMSLKNGE
FKQSFDGGEE WEDVASSEDG RVTQPVVFIR QHPFDKNKAY ALGVDGHHLV TTDQAKTWRS
FDIGDQPALQ HPPLVFHGWD SSKVIYQSEE CAGFFCITVR LLRESAAGCS WAVGHPHFAE
DMDLNQELKD RSLCVVPGLK VPFGHANRLV YSDDYFVSNI EGTEVNLHEG RPVSGVISTA
AVKKFIVAAV KSKGTEELAL FVTTDTNTWH RAEFDGHRIE QDAYTMLEST NYSLQVDVLT
SPSSNMGVLF TSNSNGTFFS RNIEHTNRDM EGTVDFEKIA GIQGIVMVNT VKNPKEVKSG
QAKKVISRIS FDDGRSFQPL KVGDKNLHLH SVTTFANIGR VFSSPAPGLV MGIGNTGDHL
QKYSDGDLYI SDDAGVTWRH ALDGPHKYEF GDQGAVVMAI SDKGKSNKIS FSLDHGKEWG
SVEIEHKIYP TMVTTTPDST SLRFLLVGKQ NEESGFIVYS IDFKGLHERK CEEDDFEKWP
ARLDENGEPD CLMGHKQFFR RRKANADCFV DEEFKDPQPI MEPCKCTAED FECEFKGSED
GKSCIPALLP VPPEGCKNPD DTFMGPSGWR LIPGDTCIRD GGKNLDHDVE WRCKDAGNVP
TSGEISVEKQ YFDARQFSAY YYLERQSSSS GNDETIVMLT SERALYVSHD HGKTWKQPLK
GEAINRIVPH PYNSDGAFLL TDGAEGFWTV DRGQSFKPFD APAPPTEERL PTLTFHPQYQ
DWLIWTGAVD CGSGDCHSNA YISKNRGDNW ELLQRYVQKC EFESREGRKD STNLIFCEQF
ENENRNNRLQ LVSSKNWFSD STVHFRDVIN YATMSEFIVV ASRDTEKPDS LVASSSVDGE
TFAEAKFPPN VNVPVQTAYT VLESSTHAVF LHVTVSNSEG AEYGSIIKSN SNGTSYVLSL
GAVNRNFRGY VDFEKMQGIE GVAVANVVSN VNKLSDGEPK KLRTMITHND GGQWTLLSPP
NKDAEGKDFG CSVEGEGVPG CSLHLHGYTE RRDERDTFSS SSAIGLMLGV GNVGDHLGGE
DEADTFITRD AGFTWKSVKK GRYIWEFGDA GSLIVIVPES KPTKTLYYSL DEGDTWLDFV
FSDVEMQIDD ISTVPSDTSK SFLLWGKELK SDYQDKLATV SVDFSGLRSS SCKLDENSAE
SHDYYLWEPK HPFQSDNCLF GHVEQYHRKK PSAQCWNDWR EPHVHSIGEN CPCTRADFEC
DYNYEPQSDG SCALVQGLAP PDAMAVCRED PEAYQYWEPS GYRRLPQSTC QGGREMDHIV
SKPCPNREEE YKKKHGISGA GLFFAIVIPI AVASAVGYYG YTRWDGKFGQ IRLGENVGTS
QGLLSRDSLL ITIPVTIIAG AVAVIKALPL LATSLWRSAS GYVRLGRNRG YSRPYASRGS
FAARRGDYTG VVDDEDELLG VEDLEADEEE EL
