VPS10_ASPTN
ID VPS10_ASPTN Reviewed; 1486 AA.
AC Q0C7E3;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 03-MAY-2011, sequence version 2.
DT 25-MAY-2022, entry version 68.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10;
DE AltName: Full=Carboxypeptidase Y receptor;
DE Short=CPY receptor;
DE AltName: Full=Sortilin vps10;
DE AltName: Full=Vacuolar carboxypeptidase sorting receptor vps10;
DE Flags: Precursor;
GN Name=vps10; ORFNames=ATEG_10391;
OS Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=341663;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIH 2624 / FGSC A1156;
RA Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA Nierman W.C., Milne T., Madden K.;
RT "Annotation of the Aspergillus terreus NIH2624 genome.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Prevacuolar
CC compartment membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250}. Note=Cycles between the Golgi apparatus and the
CC prevacuolar compartment. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAU29388.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; CH476610; EAU29388.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_001218739.1; XM_001218738.1.
DR AlphaFoldDB; Q0C7E3; -.
DR SMR; Q0C7E3; -.
DR STRING; 341663.Q0C7E3; -.
DR GeneID; 4354654; -.
DR eggNOG; KOG3511; Eukaryota.
DR OrthoDB; 1046610at2759; -.
DR Proteomes; UP000007963; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
DR SUPFAM; SSF50939; SSF50939; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Golgi apparatus; Membrane; Protein transport; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..1486
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /id="PRO_0000407508"
FT TOPO_DOM 24..1350
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 1351..1371
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1372..1407
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 1408..1428
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1429..1486
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT REPEAT 63..72
FT /note="BNR 1"
FT REPEAT 380..389
FT /note="BNR 2"
FT REPEAT 440..450
FT /note="BNR 3"
FT REPEAT 482..491
FT /note="BNR 4"
FT REPEAT 720..730
FT /note="BNR 5"
FT REPEAT 761..771
FT /note="BNR 6"
FT REPEAT 818..828
FT /note="BNR 7"
FT REPEAT 1101..1111
FT /note="BNR 8"
FT REPEAT 1142..1152
FT /note="BNR 9"
FT CARBOHYD 200
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 301
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 967
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1265
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1486 AA; 166736 MW; 27BB3A9F88B81BBE CRC64;
MIPRWLLLVS CLVLALIAQP GAAKKSSQPQ WTLKEIDHKP NALFFFEDTE TVLVNTRNGD
LHRSFDGGNE WEIVEGEDGR MKHQVALLLQ HPYDSHRAYA LGIDGHHWIT TDQAKTWREF
TLDELPAMRN PPLVFHGQDP SKVIFQGEDC VGRFCIVRSY YTDDDFRTTE ILRESVGGCS
WALGHPQFAE DSDLAKEIQN RTLCVVPGLK VPLPYANRLV YSDGYFNSDK EGTEVKLQEG
RPVAGVMRTA AIKKFLVAAA RSRGTDELAL YVTVDTKNWH RAEFGGHRLE EDAYTMLEST
NYSLQVDVLT SPKSGMGVLF TSNSDGTYFT RNVEHTNRDM RGTVDFEKIA NIQGIVMVNV
VDNPKEVENG GKNKRVVSKI SFDDGRTFQP LKVDDKKLHL HSVTSYANIG RVFSSPAPGL
VMGVGNTGDH LKDYSEGDLY ISDDAGVTWR HALEHSHKYE FGDQGAVVIA MRDDEKTNKL
EYSIDHGKSW ESVELDKKIY PIMVTTTPDS TSLKFLIVGS TSKHDGDGTY ITYAVDFAGL
HERKCEKDDF DEQWPARLDE NGEPDCLMGH KQFFRRRKPN ADCFIDEEFK DPQPIFKPCK
CTAEDFECEY KRSEDGEGCE LPPSLQPPEG KCKKPTDTFK GPSGWRLIPG NACEREGGKN
LDEEIERSCE KVGVPTDGKI KQTKQFFDSE PVVYRYMERQ SSNSGDDETV LVITRNVEFF
ISHDHGKTWE QPLKGEKVNR LVLHPYHNDV AFLLTEGKEG YYTIDRGYTF KPFKTPLPPT
QQTYLPPLAF HPQYKDWLIW TGAADCSSTS GDCHDDAYFS KNRGESWELL LRYVRRCEFE
ASENRPDSEN LIFCEQHESE SKSNPLHLLS SENFFADSRD HYTDLVNYAT MSEFIIAAFK
DPENPDALVA TTSVDGKTFA EARFPPNLHI PVKTAYTVLE STTHAIFLHV KAGSTAEYGP
LIKSNSNGTS YVLSLDAVNE NRAGFADFEK MKGLEGVAVV NVVGNVEEVS KGAKKKLKTM
ISHNDGAQWA LLPPPEKDAD GKAFGCSVTK GKGTPDCSLH LHGYTERKDE RDTYSSGSAI
GMMIAVGNVG DHLSDSEADT FITNDGGITW KSARKGRHMW EYGDAGSVIV LVPEDVPTDK
LYYSVDEGDS WEEYRFSDVE MQIEDITTVP SDTSKNFLLW GREMKSDSGK KIATVNIDFS
GLRSRQCKLD EDGHANDDYR LWEPKHPFQT DNCLFGHVEQ YHRKKPDAAC WNNWREPHVH
SIGKNCSCTR ADFECDYNFE PQSDGSCKLV PGLPLPDAEA ICRADPDRIE YWEPSGYRRV
PQSTCMGGDE FDHVKTKPCP HKEKEYEKKH GISGVGLFFA IVIPIAVAGG IGYYAYTRWD
GKFGQIRLGE GTSGSHEWLS RDSLLVTVPI AIIAGVVAVG RALPLLAMSM WRSASGYVRL
GGSRGYSRPY ASRGSFAARR GDYSSVVEDE DELLGVEDLD EDDDEN
