VPS10_CANAW
ID VPS10_CANAW Reviewed; 1586 AA.
AC C4YG73;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 1.
DT 25-MAY-2022, entry version 53.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10;
DE AltName: Full=Carboxypeptidase Y receptor;
DE Short=CPY receptor;
DE AltName: Full=Sortilin VPS10;
DE AltName: Full=Vacuolar carboxypeptidase sorting receptor VPS10;
DE Flags: Precursor;
GN Name=VPS10; ORFNames=CAWG_00192;
OS Candida albicans (strain WO-1) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=294748;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WO-1;
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA Birren B.W., Kellis M., Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
CC Prevacuolar compartment membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}. Note=Cycles between the Golgi apparatus
CC and the prevacuolar compartment. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC {ECO:0000305}.
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DR EMBL; CH672346; EEQ41997.1; -; Genomic_DNA.
DR AlphaFoldDB; C4YG73; -.
DR SMR; C4YG73; -.
DR STRING; 5476.C4YG73; -.
DR EnsemblFungi; EEQ41997; EEQ41997; CAWG_00192.
DR VEuPathDB; FungiDB:CAWG_00192; -.
DR HOGENOM; CLU_000700_0_1_1; -.
DR OMA; IFMHVTT; -.
DR Proteomes; UP000001429; Chromosome 1, Supercontig 1.1.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
PE 3: Inferred from homology;
KW Glycoprotein; Golgi apparatus; Membrane; Protein transport; Receptor;
KW Repeat; Signal; Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..1586
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /id="PRO_0000407509"
FT TOPO_DOM 22..1394
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 1395..1415
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1416..1586
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 450..460
FT /note="BNR 1"
FT REPEAT 496..507
FT /note="BNR 2"
FT REPEAT 792..801
FT /note="BNR 3"
FT REPEAT 846..856
FT /note="BNR 4"
FT REPEAT 1136..1146
FT /note="BNR 5"
FT REPEAT 1177..1187
FT /note="BNR 6"
FT REGION 692..711
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1527..1586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 1004
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1300
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1586 AA; 179334 MW; 913E6EE4365A484E CRC64;
MRNNWNWLIF LVPFILSLTT AYTPDISVVK NKSPAREIKY FDDSSNLLVL RDEHLLISKN
DGKSFEEIPD IKDPIIYFEM DPTNKNRAFA MTLSQKQYIT EDQGNKWRTF EIDIFNGEMA
SIPKITFNFE NPNYLMISNY ECPEGQRLNR NCKHRYFFTK DGFKSKPNKL PVDAHVCRFA
KSTKTSKIGK SETIFCTVNQ LNSYGHIVES HLYNSNDFFQ NKNEIKIKPL DSSSGEIIDV
KIEEDFMIVV SRMDKFNEKS LINAYVSRDG ENFVRADLDI DIKYGVMSFL PSSVSSLFLT
IMDFNSRAFQ TASFYGSDSS GLHFTKLLDN VAGGNIQKIE NIDGAWIANI GVDSNNPYDG
DESLLDNLFG GTYAKSIVSK VSINDGKDWS LIKLNDNSCK IEDECSLHLW DFTELDGEGK
FVTGPTPGIL LGVGNKGKNL AHEFEKMKTY VSRDGGVTWN KALDFPAVFA FGDQGNVILA
VPYNGKKKYE AAKHFYFSLD QGKSWEKVDL EHPIYPLSIL TTIDGTSRKF IIGGIDDSRR
AENEYIYSVD FTNAFDGKTC GDDDFEEFVA RKSNDNGNDE PLCVYGHREK FRRRKQDAKC
FVNKLFEDIK VIEDPCQCTE HDFECGPGFR LSEKESTNVC VPDRKQLTQL CQSKSEITLP
NKVLVEGNKC NMGDKKLEDF VSQETLKCSD YVDNGGDGNG DEKNPNQGDS NQIEVHINDF
EGKLSQYQYI AESKDNNAAD NVVIKTMDDR LWISNNGGVS FVRVPISDKI LGFYAGPIPG
QITLITATNI IYVSDDGGAT FIKRKVPTQP SPRVDRAIAF HSKNVERFIW FGEECESNGR
CTSNAYITDD AGATFNKLMA NVRTCDYVGA VLESGDHELI YCSGQNSLDN NNNNNKNKNK
LALFSLKESS SEEPKKIFEN IVGYAITGTY VVVATIDDKT DSLLSKVTVD GDIFADADFP
HDLKVEPHQA FTVLDSSSKA VFMHVTTNEK PNFEYGQLLK SNSNGTYFVL TLDNVNRNTV
GYVDFDKIDG LEGTIIANVV ANAQANEGTK NLQTLISHND GSEWDKLVPP TIDSEGIKYP
CTGQSLNKCA LHLHGFTERA DYRDTFSSGS ATGFLIGVGN VGEFLTPMDD PSTATFLSTD
GGVTWKEIKK GVYMWEYGDQ GTILVLVNAV ENTDVLYYSL DEGQTWKEYK FSEYKVNIYD
LATVPTDTAR KFIIFAENPK DHRDIQTFTI DFTNIYPRQC QLNLDDPEHD DYEYWSPTHP
IGGDKCIFGH ESKYLRRAKG HTDCFIGSAP LSEGYKLEKN CSCTRRDYEC DYNYVRDVND
NTCKLVKGMT SADRKTTMCS KENAFQYFES TGYRKIPLST CKGGQQFDNW NPKPCPGKEK
QFNEYYGREV KGHKLFFLIF IPLIIFLATV LFVYDRGIRR NGGFKRLGQI RLNDDDDDFN
PIENDQIDVV VNKIVKGGVY TVAVLIATVK TIRKIDRMML EKLGNVIFRR SPGRRNYVSV
PNDLDEEEEL FGDYQDNLDD ELEDAVFNQD DNLVRTPFAD DVEEEEEERE GEGEGEQSNP
SDERLFDIDD NEDEDEQHEV NKPTTS
