VPS10_CANDC
ID VPS10_CANDC Reviewed; 1571 AA.
AC B9W9N8;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 24-MAR-2009, sequence version 1.
DT 03-AUG-2022, entry version 58.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10;
DE AltName: Full=Carboxypeptidase Y receptor;
DE Short=CPY receptor;
DE AltName: Full=Sortilin VPS10;
DE AltName: Full=Vacuolar carboxypeptidase sorting receptor VPS10;
DE Flags: Precursor;
GN Name=VPS10; ORFNames=CD36_11680;
OS Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 /
OS NRRL Y-17841) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=573826;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841;
RX PubMed=19745113; DOI=10.1101/gr.097501.109;
RA Jackson A.P., Gamble J.A., Yeomans T., Moran G.P., Saunders D., Harris D.,
RA Aslett M., Barrell J.F., Butler G., Citiulo F., Coleman D.C.,
RA de Groot P.W.J., Goodwin T.J., Quail M.A., McQuillan J., Munro C.A.,
RA Pain A., Poulter R.T., Rajandream M.A., Renauld H., Spiering M.J.,
RA Tivey A., Gow N.A.R., Barrell B., Sullivan D.J., Berriman M.;
RT "Comparative genomics of the fungal pathogens Candida dubliniensis and
RT Candida albicans.";
RL Genome Res. 19:2231-2244(2009).
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
CC Prevacuolar compartment membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}. Note=Cycles between the Golgi apparatus
CC and the prevacuolar compartment. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC {ECO:0000305}.
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DR EMBL; FM992688; CAX45523.1; -; Genomic_DNA.
DR RefSeq; XP_002417808.1; XM_002417763.1.
DR AlphaFoldDB; B9W9N8; -.
DR SMR; B9W9N8; -.
DR STRING; 42374.XP_002417808.1; -.
DR EnsemblFungi; CAX45523; CAX45523; CD36_11680.
DR GeneID; 8045358; -.
DR KEGG; cdu:CD36_11680; -.
DR CGD; CAL0000168359; Cd36_11680.
DR VEuPathDB; FungiDB:CD36_11680; -.
DR eggNOG; KOG3511; Eukaryota.
DR HOGENOM; CLU_000700_0_1_1; -.
DR OrthoDB; 1046610at2759; -.
DR Proteomes; UP000002605; Chromosome 1.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
PE 3: Inferred from homology;
KW Glycoprotein; Golgi apparatus; Membrane; Protein transport; Receptor;
KW Repeat; Signal; Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..1571
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /id="PRO_0000407510"
FT TOPO_DOM 23..1382
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 1383..1403
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1404..1571
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 451..461
FT /note="BNR 1"
FT REPEAT 497..507
FT /note="BNR 2"
FT REPEAT 788..797
FT /note="BNR 3"
FT REPEAT 842..852
FT /note="BNR 4"
FT REPEAT 1124..1134
FT /note="BNR 5"
FT REPEAT 1165..1175
FT /note="BNR 6"
FT REGION 1527..1571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 992
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1288
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1571 AA; 177468 MW; D7A887223604307D CRC64;
MRNNNCNWLI FLLAFILSLT TAYTPDISVV KNNSPAREIK YFDDSSTLLV LRDDHLLISK
NDGKSFEEIS DIKDPIIYFE MDPTNKNRAF AMTLSQKQYI TEDQGNRWRT FEIDLFNGEM
ASIPKITFNF ENPNYLMISN YECPEGQRLN RNCKHRYFYT KDGFKSKPTK LSVDAHVCRF
AKSTKTSKIG NSETVFCTVN QLNSYGHIVE SHLYNSNDFF QTKNEIKIKP LDSSSGEIID
IKIEEDFMIV VSRMDKFNEK SLINAYVSRD GENFVRADLD IDIKYGVMSF LPSSVSSLFL
TIMDYNSRAF QTASFYGSDS SGLHFTKLLD NVAGGNIQKI ENIDGAWIAN IGVDSNNPYD
GDKSLLDNLF GGTYAKDIVS KVSINDGKDW SLIKLNDNSC KIEDDCSLHL WDFTELDGEG
KFVTGPTPGI LLGVGNKGKN LAHKFDKMKT YVSRDGGVTW DKALDFPAVF AFGDQGNVIL
AVPYNGKKKY DAAKHFYFSL DQGKSWDKVD LKHPIYPLSI LTTIDGTSRK FIIGGIDDSR
KSENEYIYSV DFTNAFDGKT CGDDDFEEFV ARKSNIDDEP LCIYGHREKF RRRKQDAQCF
VNKLFEDVKV IEDPCQCTEH DFECGPGFKL SEKDSANVCV PDRKQLSRLC QSKSELSLPN
KVLVEGNKCN MGDKKLEDFV SQETLKCSDY VDGDNGDKQN PNQGDSNQIE VHINDFEGKL
AQYQYIAESQ DKNAADNIVI KTMDDRVWIS NNGGVSFVRV PISDKILGFY AGPIPGQVIL
ITATNLIYVS DDGGATFIKR RIPTQPSPRV DRAIAFHNEK VERFIWFGEE CESNGRCTSN
AYITDDAGAT FNKLMANVKT CDYVGAVLES GDDELIYCSA QNSLDNNKLA LFSLKESSSE
EPKKVFENIV GYAIAGTYVV VATIDDKKDS LLSKVTVDGD VFADADFPHD LKVEPHQAFT
VLDSSSKAIF MHVTTNEKPN FEYGQLLKSN SNGTYFVLAL DNVNRNTVGY VDFDKIDGLE
GTIIANVVAN AQANEGTKNL QTLISHNDGS EWDKLVPPTV DSEGKKYQCT GQPLNKCALH
LHGFTERADY RDTFSSGSAT GFLIGVGNVG EFLTPMDDSS TATFLSTDGG VTWKEIKKGV
YMWEYGDQGT ILVLVNAVEE TDVLYYSLDE GQTWKEYGFT DYKIKAHDLA TVPTDTARKF
IIFAQNSKDH RDIQTYTIDF TNIYPRQCQL NLDDPEHDDY EYWSPVHPIG GDKCMFGHES
KYLRRANGHT DCFIGSAPLS DGYKLEKNCS CTRRDYECDY NYVRDVNDNT CKLVKGMTSA
DRKTTMCSKE NAFQYFESTG YRKIPLSTCK GGQQFDNWNP KPCPGKEKIF NEYYGREVKG
HKLFFLIFIP LIIFLGTVLF VYDRGIRRNG GFKRLGQIRL NDDDDDFNPI ENDQIDVVVN
KIVKGGVYTV AVLIATVKTI RKIDRMMLEK LGNVIFRRSP GRRNYVSVPN DFDEEEELFG
DYQDNLDDEL EDAVFNQDDN LVRTPFVDDI EETETEAQQG EQSNPRDERL FDIDDNEEEE
QQQEVSKPAP S
