VPS10_CLAL4
ID VPS10_CLAL4 Reviewed; 1525 AA.
AC C4Y3C1;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 1.
DT 25-MAY-2022, entry version 48.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10;
DE AltName: Full=Carboxypeptidase Y receptor;
DE Short=CPY receptor;
DE AltName: Full=Sortilin VPS10;
DE AltName: Full=Vacuolar carboxypeptidase sorting receptor VPS10;
DE Flags: Precursor;
GN Name=VPS10; ORFNames=CLUG_03034;
OS Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Metschnikowiaceae; Clavispora.
OX NCBI_TaxID=306902;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42720;
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA Birren B.W., Kellis M., Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Prevacuolar
CC compartment membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250}. Note=Cycles between the Golgi apparatus and the
CC prevacuolar compartment. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC {ECO:0000305}.
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DR EMBL; CH408078; EEQ38908.1; -; Genomic_DNA.
DR RefSeq; XP_002617590.1; XM_002617544.1.
DR AlphaFoldDB; C4Y3C1; -.
DR SMR; C4Y3C1; -.
DR STRING; 306902.C4Y3C1; -.
DR EnsemblFungi; EEQ38908; EEQ38908; CLUG_03034.
DR GeneID; 8498263; -.
DR KEGG; clu:CLUG_03034; -.
DR VEuPathDB; FungiDB:CLUG_03034; -.
DR HOGENOM; CLU_000700_0_1_1; -.
DR InParanoid; C4Y3C1; -.
DR OMA; IFMHVTT; -.
DR Proteomes; UP000007703; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 3.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
DR SUPFAM; SSF50939; SSF50939; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Golgi apparatus; Membrane; Protein transport; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..1525
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /id="PRO_0000407513"
FT TOPO_DOM 22..1345
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 1346..1366
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1367..1399
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 1400..1420
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1421..1525
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT REPEAT 58..67
FT /note="BNR 1"
FT REPEAT 101..111
FT /note="BNR 2"
FT REPEAT 371..380
FT /note="BNR 3"
FT REPEAT 439..449
FT /note="BNR 4"
FT REPEAT 484..493
FT /note="BNR 5"
FT REPEAT 1088..1098
FT /note="BNR 6"
FT REPEAT 1130..1139
FT /note="BNR 7"
FT REGION 1503..1525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1511..1525
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 959
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1252
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1525 AA; 170264 MW; 10FE775A0D395F8A CRC64;
MNLRASCIAA FLCLLVQLCA ADFSPEVTHR IVKGIGWDIS YFEDSSNVIH VGEKMVEMSY
DDGVTWTEIE TIGKSSDILV KFDPINVNRA FVFSRIGDTH FVTDDKGKTW RSFKVQPKKS
LKDRELGMHH VFNFKDDSVL IKLEYCKQYP EADDCDVSYF YSSNSLKSDP QLLPIDAKVC
VVNTLLDEPT ILCVKDTRNS FGHVVKSELV SSKDLFKTSE SIKHPGFDSG RIIDVRLESS
FLVVVTQKDR FNELSSISIS VSKDGKTFDT ADLAFQMAYG AIRFLPSDPQ SLFLTVAAST
SKDTRPQGTL YSSDSSGLHF KKLLDNVDLG YSARVEYVHG VWLAKTFEED PIVEPNDDYF
GSPIAKTSSH ISIDNGLTWN KLEILNDDSC KLKDGCSLNL LRFDAIEDKN KYVTGPTPNI
LMGFGITGNT DNFFKAKTYI SRDGGLTWTN VFSGPGIHAF GDQGNVIMYV PFSGRNHGPA
TEVRYSLNQG RSWGTYKLKE PCFPQELITT TDGTNTKFVL SGIVEHQQMS EVLYAFDFSK
AFDGNKCKDS DMEKVYARVS PKDGQPNCIY GFKESFMRRK ADARCFIDRT FEDVKVDVEQ
CPCTQQDYEC SPYFKLSEKG VCVPDPKKIA EKCKSESKDT LKLPDMQIVA ENKCEQKSDS
SFVTETEFKC KDFTGENVPS SITIGQSEFD GFLSQYSYVA TGPDLSDNLI VKTDTGLIYA
SNNGGTSFVR VPFKEKIRGF YVGPSLGRVI MITDGDVFYA SNNGANTFYK YKVPTSASNG
DVTISFHPTD ESRFIWLSGN CAVGSSTCVA YHTEDFGRSF EKLIDNAMAC DYVSPVLDIT
STELIYCTVV DGNKKKLASS TNYFKEAEIE YVLDDIVAYA IKSNFVVVAT LDEAHTMLKA
KVTADGFVFA DVDFPSDFKI EAQTAFTILE SSPHSIFMHV TTDSTSGHEK GAILKSNSNG
TYYVLSLSDV NRNEVGYVDY DRLGLLEGVL IANTATDSKE GKNKKTQISF NDGSQWNYIA
PPAVDSDGKE YACKGQPLSK CSLHLHGFTE RPDYRDTFSS GSAVGLLIGM GNVGEYLKPV
TDDQTAAFMS ADGGLTWKEI KKGVYHWDFG DQGTILLLVD AAKDTDEFIF SKDEGATWET
MKFASSPVKV LDLATVPSDT SLKFVIFAGS HQSQSSTQLF AVDFSQFFPR QCQVDLENPE
SDDFEYWTPM HPESTERCLF GHEAMYLRRA AGHDDCFIGS TPLDQGYKMV RNCTCTRNDY
ECDYNYFRDN DGTCKLVKGM NAANRMAEMC RKPGVFEYFE PTGYRKIPLS TCVGGKQFDA
LKPRACPGHE KEFNEAHGRD VGGSKIFILI FIPLLVFFSA VFFVYDRGIR RNGGFQKLGQ
IRLDDGDDDF NPIEENIVDV VVNKTVRGAI VVAAGTFAVF KTIRKIDRAM FDKVTSLLFG
RRPGQRNYVR VPDDEDELFG TFDENYEDEL NEAADVDFNV DEEPEEFTEL TAEPANVDER
LFDIDDQSED DAVSAEHPEP ESTHE
