VPS10_COCP7
ID VPS10_COCP7 Reviewed; 1486 AA.
AC C5P311;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 03-MAY-2011, sequence version 2.
DT 25-MAY-2022, entry version 54.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10;
DE AltName: Full=Carboxypeptidase Y receptor;
DE Short=CPY receptor;
DE AltName: Full=Sortilin VPS10;
DE AltName: Full=Vacuolar carboxypeptidase sorting receptor VPS10;
DE Flags: Precursor;
GN Name=VPS10; ORFNames=CPC735_039630;
OS Coccidioides posadasii (strain C735) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=222929;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C735;
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Prevacuolar
CC compartment membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250}. Note=Cycles between the Golgi apparatus and the
CC prevacuolar compartment. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EER28699.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; ACFW01000014; EER28699.1; ALT_INIT; Genomic_DNA.
DR RefSeq; XP_003070844.1; XM_003070798.1.
DR AlphaFoldDB; C5P311; -.
DR SMR; C5P311; -.
DR EnsemblFungi; EER28699; EER28699; CPC735_039630.
DR GeneID; 9696338; -.
DR KEGG; cpw:CPC735_039630; -.
DR HOGENOM; CLU_000700_0_0_1; -.
DR Proteomes; UP000009084; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
PE 3: Inferred from homology;
KW Glycoprotein; Golgi apparatus; Membrane; Protein transport; Receptor;
KW Repeat; Signal; Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..1486
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /id="PRO_0000407514"
FT TOPO_DOM 21..1356
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 1357..1377
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1378..1405
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 1406..1426
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1427..1486
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT REPEAT 57..66
FT /note="BNR 1"
FT REPEAT 376..385
FT /note="BNR 2"
FT REPEAT 436..445
FT /note="BNR 3"
FT REPEAT 478..487
FT /note="BNR 4"
FT REPEAT 718..728
FT /note="BNR 5"
FT REPEAT 817..826
FT /note="BNR 6"
FT REPEAT 1100..1110
FT /note="BNR 7"
FT REPEAT 1141..1150
FT /note="BNR 8"
FT CARBOHYD 295
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 966
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1262
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1486 AA; 167179 MW; 2063962D4E4B5458 CRC64;
MILRRLLLAG SLLLASFATA KKDGPKIEVT ELEHEPKHLF YFEDSDVVML QHKYDAYIST
DAGVSWAPVK GPDDHMKGKV KAIYHHPYDR TKAYVLGQER THWTTDDTGK SWREFTIDQA
LPRSGNPLSF HGKDSNKVIL HTIECSGFIC QMPALYTTDG FKSHKILTKA QHGCSWAIST
PEFAAREEFP ENVDNRILCM FTGLHSPIGT QKRLLYSDDF FEGDRGTEVP LNNGRPVSDI
VSMVGVKKFL VAAARSPRTN ELALYVSDDA SRWHQALFDG HRLENNGYTI LESTNYSIQV
GVKTSGGFNP MSALFTSNSD GVSFTRNAEH LNANNLGYVD FEKIAGIQGI FLVNTVTNWE
EIEEHHGGKK KIVSKISFDD GRTFHDIKAG DKNLHLHSVT HIHNTGRVFS SPAPGLVMGV
GNVGDSLKEY DDGDLYVSDN AGITWWRALE DAHKYEFGDQ GSVLVAVYDE GRTNKISYSL
NHGKDWKTAE LPVKIRARTL TTTPDSTSLK FLLLGTGKGS SERKHYVIAL DFSDVHERKC
SKDDFERWPA RLNEKEEPDC LMGHKQFYRR RKGKSECFIG EEFKDPVPEL ERCKCTEEDF
ECDFNFVRSE DRKDCVPARS LPVPEGQCKK PEDKYTGSSG FRLIPGDDCI KEGGLELDKP
KERSCSDTAK EPVSGEIGVS IQHFDANKPA EYYYMERPTL SKDKDETVML LTDKLEVFMT
KDHGKTWQQI LAGKNIAKLW PHTYNNDIMY YVTGEKKVFL TKNRGDSFRE FETKLPPNRD
RLPVLAFHPD PERSEWLIWT GADNCERGGD CHSVAHYSTD GGDEWHTLMR YVGRCEFVGK
GGVRKTDELI FCAQHENEDP KNKHFRLLSS ENWFTNKKIH YKDILDFRTM AEFIIVAARA
GKDSLKVGAS IDGDTFADAE FPPNFDVKTQ QAYTVLDSST HSVWLHVTVH NVPDHQFGSI
IKSNSNGTSY VLSLSNVNRN NADYVDFEKM QGLEGVALVN VVANVDEVVK GAAKKLRTMI
THNDGAEWDY VRPPAMDADG RKYGCSPGKK GTAECGLHLH SYTERRDFRD TFSSPSAVGL
MLAVGNVGDH LTLKSEGDTF ITRDGGIEWH SVKKGNYIWE YGDQGSIIVI VPESKPTKTI
FYTLDEGRTW IEFEFTKVEM QISDITTVPS DTSRNFLLWG TEVGSGAKPG FATVNLDFSG
LKERSKKCVL KEEKPEADDY YIWEPKHPLL EDNCLFGHVA RYHRKKPDSQ CFNGGEFEKL
HNVSTNCPCT RQDYECDYNY ERQSDGSCAL VEGLQPLDPK RICTEDPNAI EYYEPTGYRR
IPLTTCEHGV KLDGFKAFPC PNKEKEFEKK HPGLRGVGLF FAIVIPIAAA AAVGYWVYNR
WDGKFGRIRL GETSRSGSWL SRDSPLVVVP VAIIAGTVAV MSALPLLAAS LWRSFRGWMP
VGRGSSRPYS SRGAFAARRG DYVGVVEDED ELLGAEDFDG DEDEEV
