VPS10_COLGM
ID VPS10_COLGM Reviewed; 1518 AA.
AC E3QER5;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 1.
DT 25-MAY-2022, entry version 41.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10;
DE AltName: Full=Carboxypeptidase Y receptor;
DE Short=CPY receptor;
DE AltName: Full=Sortilin VPS10;
DE AltName: Full=Vacuolar carboxypeptidase sorting receptor VPS10;
DE Flags: Precursor;
GN Name=VPS10; ORFNames=GLRG_04515;
OS Colletotrichum graminicola (strain M1.001 / M2 / FGSC 10212) (Maize
OS anthracnose fungus) (Glomerella graminicola).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Glomerellaceae; Colletotrichum;
OC Colletotrichum graminicola species complex.
OX NCBI_TaxID=645133;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M1.001 / M2 / FGSC 10212;
RX PubMed=22885923; DOI=10.1038/ng.2372;
RA O'Connell R.J., Thon M.R., Hacquard S., Amyotte S.G., Kleemann J.,
RA Torres M.F., Damm U., Buiate E.A., Epstein L., Alkan N., Altmueller J.,
RA Alvarado-Balderrama L., Bauser C.A., Becker C., Birren B.W., Chen Z.,
RA Choi J., Crouch J.A., Duvick J.P., Farman M.A., Gan P., Heiman D.,
RA Henrissat B., Howard R.J., Kabbage M., Koch C., Kracher B., Kubo Y.,
RA Law A.D., Lebrun M.-H., Lee Y.-H., Miyara I., Moore N., Neumann U.,
RA Nordstroem K., Panaccione D.G., Panstruga R., Place M., Proctor R.H.,
RA Prusky D., Rech G., Reinhardt R., Rollins J.A., Rounsley S., Schardl C.L.,
RA Schwartz D.C., Shenoy N., Shirasu K., Sikhakolli U.R., Stueber K.,
RA Sukno S.A., Sweigard J.A., Takano Y., Takahara H., Trail F.,
RA van der Does H.C., Voll L.M., Will I., Young S., Zeng Q., Zhang J.,
RA Zhou S., Dickman M.B., Schulze-Lefert P., Ver Loren van Themaat E.,
RA Ma L.-J., Vaillancourt L.J.;
RT "Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered
RT by genome and transcriptome analyses.";
RL Nat. Genet. 44:1060-1065(2012).
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Prevacuolar
CC compartment membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250}. Note=Cycles between the Golgi apparatus and the
CC prevacuolar compartment. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC {ECO:0000305}.
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DR EMBL; GG697344; EFQ29371.1; -; Genomic_DNA.
DR RefSeq; XP_008093391.1; XM_008095200.1.
DR AlphaFoldDB; E3QER5; -.
DR SMR; E3QER5; -.
DR STRING; 645133.E3QER5; -.
DR PRIDE; E3QER5; -.
DR EnsemblFungi; EFQ29371; EFQ29371; GLRG_04515.
DR GeneID; 24409880; -.
DR VEuPathDB; FungiDB:GLRG_04515; -.
DR eggNOG; KOG3511; Eukaryota.
DR HOGENOM; CLU_000700_0_0_1; -.
DR OrthoDB; 1046610at2759; -.
DR Proteomes; UP000008782; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
PE 3: Inferred from homology;
KW Glycoprotein; Golgi apparatus; Membrane; Protein transport; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..1518
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /id="PRO_0000407515"
FT TOPO_DOM 27..1385
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 1386..1406
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1407..1435
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 1436..1456
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1457..1518
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT REPEAT 64..74
FT /note="BNR 1"
FT REPEAT 107..118
FT /note="BNR 2"
FT REPEAT 453..464
FT /note="BNR 3"
FT REPEAT 496..506
FT /note="BNR 4"
FT REPEAT 751..761
FT /note="BNR 5"
FT REPEAT 848..857
FT /note="BNR 6"
FT REPEAT 1132..1142
FT /note="BNR 7"
FT REPEAT 1179..1188
FT /note="BNR 8"
FT REGION 657..681
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 307
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 332
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1001
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1293
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1518 AA; 170158 MW; 919A6A53E2E11998 CRC64;
MRLRGKTVAS WRILLSVLTL AAAVQAKDEP TIKVTTIKHP PLNLNYFEDS NTVLYQDISE
RNLYRSEDAG ITWDRVKDIP DNQASLLTMH SFDKNRAYVL TQGTEHFKTT DRGKSWQKFS
SGAPPNIFMG GDILHFHAGD PDRVIFNGAD CIGIFCDLIT LYTTDNFKSK AKFLRGNTEG
CYWAKSSDLF TTGKDDLDKQ RILCVVRDNF SPFKEDNRLL ASDNYFQKVD NKVQEFEPDM
DTNHGVQGVV SLAVVKKYLM VATSSLNTDE MGLFVTDDTI KWHRAMFPTS HGHKVNQGAY
TVLESTNYSI QIDVMNTRPS NPTGVMFTSN SNGTFFTENL EHTNRNTNGH VDFEKITGVQ
GIFMVNVVQN WEEVEKDTNR GGKHVQKEIV SKITFDDGRT FHDLKSGGDQ LHLHSVTDLD
NVGRVFSSPA PGLVLAIGNK GKSLGKFGDG DVYVSDDAGV TWKKALDGPH KYEFGDLGSI
LVAVKDSHKE DIGEIRYSLD HGESWKTAPL PDDLKIKPEL LTTTQDSTSL KFLLVGKTGG
DNPKFHIIAL DFEGLHERTC KEDDFEDWHA RLDENGKPSC LMGHKQTYRR RKKTADCFLN
QEFKDPVPVT EDCECTDADF ECDYNFIRDG DNCKKAGPII APDNVCKNAR PDDTFKGSSG
WRKIPGNTCK RKSGDQKDDP VERKCSEAVN APAAPADGKI KAVQHVFKTD FKDFEKIYLE
RGESSTEVDE TIIVRPVEYS GNSMRADNQI WRTKDHGKNW ERILQDEDVR GIYPHSFFKD
VVFFTTDSKK VLYTIDRAEH FHSFEAPTKP GSGNPLSFHP DKKDWLIWVG EKCEKVNGKE
TCFTEASISR DRGDNWKTAM RYVQKCEFTG HSAYRYRDLR QIVCLAHKEE NNEKDNPKVI
VSSNDFFDED KTFHQDRVKN FALMAEFIVV AAEDQEKQGL RALASLDGVS YAEAHFPVNF
KVSHQNAYTV LDSSTHAVNL FVATETAEGR RYGSIIKSNS NGTSYVMSAQ AVNCNDQYYV
DFEKIPGLEG VALINTVANR DKRNEPKKVQ TQISHNDGSQ WAFLPPPKAD VDGKSYSCSS
TEGDEKCALH LHHYTERSDK RKTFSAATAV GLMFGNGNVG SSLSSLKEAD TFMTTDAGIT
WKNVKKGAWT WQYGDQGSIV VLVQRASREN PVKTKMISYT TDEGKTWKDF AFTDKEVTVL
DISTLRSGAS RNFLIWCKDD GGETFSVNVD FTGLADRPCK SDEGSSDYYL WSPKHPSQPD
NCLFGHVSQY LRKKDDANCY NDARVQHLYQ VENCTCTRAD YECDYNYELG TDKQCKLVPG
TSPISAEQWC KENPDAVEYY EPTGFRRIPL TTCIGNGHNE LDKQSKAHPC AGKEDEFERR
RRTSGIAIFF AVVIPFGLAG AIGWWVYRNW NGKIGQIRLG ESSSLDNDAP WVKYPVIALS
AVVAVAAALP LVASALWRRA TSAYESVSGG GGGGGSWLSG RGNRRFTTRD SFARGRGDYA
VVDDDEGELL GDDSDEEV
