VPS10_COPC7
ID VPS10_COPC7 Reviewed; 1502 AA.
AC A8PE82;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 10-AUG-2010, sequence version 2.
DT 25-MAY-2022, entry version 51.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10;
DE AltName: Full=Carboxypeptidase Y receptor;
DE Short=CPY receptor;
DE AltName: Full=Sortilin VPS10;
DE AltName: Full=Vacuolar carboxypeptidase sorting receptor VPS10;
DE Flags: Precursor;
GN Name=VPS10; ORFNames=CC1G_10357;
OS Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)
OS (Inky cap fungus) (Hormographiella aspergillata).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Psathyrellaceae; Coprinopsis.
OX NCBI_TaxID=240176;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003;
RX PubMed=20547848; DOI=10.1073/pnas.1003391107;
RA Stajich J.E., Wilke S.K., Ahren D., Au C.H., Birren B.W., Borodovsky M.,
RA Burns C., Canbaeck B., Casselton L.A., Cheng C.K., Deng J., Dietrich F.S.,
RA Fargo D.C., Farman M.L., Gathman A.C., Goldberg J., Guigo R., Hoegger P.J.,
RA Hooker J.B., Huggins A., James T.Y., Kamada T., Kilaru S., Kodira C.,
RA Kuees U., Kupfer D., Kwan H.S., Lomsadze A., Li W., Lilly W.W., Ma L.-J.,
RA Mackey A.J., Manning G., Martin F., Muraguchi H., Natvig D.O.,
RA Palmerini H., Ramesh M.A., Rehmeyer C.J., Roe B.A., Shenoy N., Stanke M.,
RA Ter-Hovhannisyan V., Tunlid A., Velagapudi R., Vision T.J., Zeng Q.,
RA Zolan M.E., Pukkila P.J.;
RT "Insights into evolution of multicellular fungi from the assembled
RT chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus).";
RL Proc. Natl. Acad. Sci. U.S.A. 107:11889-11894(2010).
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
CC Prevacuolar compartment membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}. Note=Cycles between the Golgi apparatus
CC and the prevacuolar compartment. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC {ECO:0000305}.
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DR EMBL; AACS02000007; EAU81066.2; -; Genomic_DNA.
DR RefSeq; XP_001840743.2; XM_001840691.2.
DR AlphaFoldDB; A8PE82; -.
DR SMR; A8PE82; -.
DR STRING; 5346.XP_001840743.2; -.
DR EnsemblFungi; EAU81066; EAU81066; CC1G_10357.
DR GeneID; 6017395; -.
DR KEGG; cci:CC1G_10357; -.
DR VEuPathDB; FungiDB:CC1G_10357; -.
DR eggNOG; KOG3511; Eukaryota.
DR HOGENOM; CLU_000700_0_0_1; -.
DR InParanoid; A8PE82; -.
DR OMA; ATMSEFI; -.
DR OrthoDB; 1046610at2759; -.
DR Proteomes; UP000001861; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
PE 3: Inferred from homology;
KW Glycoprotein; Golgi apparatus; Membrane; Protein transport; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..1502
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /id="PRO_0000407516"
FT TOPO_DOM 27..1394
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 1395..1415
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1416..1502
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 63..74
FT /note="BNR 1"
FT REPEAT 106..116
FT /note="BNR 2"
FT REPEAT 460..470
FT /note="BNR 3"
FT REPEAT 502..511
FT /note="BNR 4"
FT REPEAT 792..802
FT /note="BNR 5"
FT REPEAT 1078..1087
FT /note="BNR 6"
FT REPEAT 1153..1163
FT /note="BNR 7"
FT REPEAT 1195..1204
FT /note="BNR 8"
FT CARBOHYD 328
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1004
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1314
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1502 AA; 169004 MW; 282758BED5970282 CRC64;
MAGLTTAFGG RLILWFLVLW ISITAAQKPE HAISSFDNPP ARVFFFDDTL SVIYHDRISG
NLYVSQDEGK SWKKAEGIPE RSVSVVIEHP YDTRLAFALT EGTKHYRTED RGKTWRPFTI
PDSPAVVARP LSFHSDPKKW RYVIYQGTKC EGIVCYDVAY YSKDAFSDEP KLMLTDVNRC
QFAHSNKDFK HDAHPDLIFC VASDQRTVTG AHNLASQRLY SSTDFFDKDK KVEDLGIGKN
ARGVVAFAIV SRFGVVALKD LSRSDGEMQL YVTTDAKNWA KGHFPHASSA RLRENAYTIV
ESTTHSLGVD VVLKDRSTIG TLFLSNSNGT YFVESLKDTN RNEQGFVDYE RVYGVDGVGL
ANVVANAQEV EGRNAPKKLR SMITFDDGRR WQPLRAPPRD DEGNRINCDP SDSEKCALHL
HSVTTPHNYG RIFSSPAPGL VMGVGTVGPH LGSYEDSDTF LSTDAGLTWK MVTKEAHQYE
FGDQGSILVV VNNEDWTSEI KYSLNLGKTW QTYDFGIKIR SRGLITLPDS TSQKFLLLGL
TSRQDQEKDM RLGKVVVIYL DFAKTRKNKC TEKDFDKWYA RPTGKRECIM GHKQWYKRRK
VDADCYVGEK FIDPEGHEEN CECTEEDYEW SVVVYFFVYF TDAPSLSDYN FVRNGDKCEP
AGPEPVPPGV CTKNDPTEKY MGSSGFRKIP GNTCVGGKKL DQPVEKYCSK ARPAEGSVIH
TKFQFDSPIV QFAYFPESTT ILVRLLDESI WQSSNEGYTW SQLFKNERFV AFYHHKYSNE
RAYLITRTKK FYYTTDTGRS WNTMTAPNPP NTFDARVLRF SPSDTDFLIW TGNADCERGK
TNCHAEAHFS RKNGRGWTLI DKYVRNCAFA EDKDLSADPS DIICESVKEK KGMQVKGARM
ELVAGSGYYQ GRKRVLFENV VGFAKFSEFL VVAGLQPETK SLELQVSLDG THFASGKFPP
SMSPNTHAYT VLESTTNALF IHMTMTTAPP PAPQWGTLLK SNSNGTYFGV SIENVNRNER
GYVDFEKMIG LDGIALVNVV QNVDVLAEGG GVRKGGLGMG SGTTTRQVGE LKKLQTRITH
NDGSTWRPLT PPVVDSLGNK YECEGTQCAL HIHGYTARRD PRATYSSPAA VGVMMAVGNV
GTHLAPYGDS DTFISRDGGF TWEEVHKDAH MWEYGDSGSI IIIVNDEEPT DHLMFTTDEG
LTWKEYRFSE EKVRVMAVTN VPSDRSRRFL LFGTQEGRKG GSVAIHVDFT ELTSRQCLLN
EQNPGNDDFE LWSPSEDRVE LCLFGRQTLY HRRVRDAQCY IGNQPKVEAK IQRNCTCTRV
DFECEFNYIK NDKDECVLVP GTTPLPNDDS VCKKGEEYWY ERTPYRLIPY SSCEGGTRLD
RGTAHRCPGV KSKSGWFWMV MLVLPFGFTA LVGYWYYRRS GMARGTIRLP GGDNRAPGST
FGSGSGVLDT LASVPWFLVG MAGIAMDWLS SKLDEGISRS RRGYRNVPID EDAQILRFED
ED
