VPS10_DEBHA
ID VPS10_DEBHA Reviewed; 1570 AA.
AC B5RU30;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 04-NOV-2008, sequence version 1.
DT 25-MAY-2022, entry version 55.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10;
DE AltName: Full=Carboxypeptidase Y receptor;
DE Short=CPY receptor;
DE AltName: Full=Sortilin VPS10;
DE AltName: Full=Vacuolar carboxypeptidase sorting receptor VPS10;
DE Flags: Precursor;
GN Name=VPS10; OrderedLocusNames=DEHA2E16918g;
OS Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX NCBI_TaxID=284592;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
CC Prevacuolar compartment membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}. Note=Cycles between the Golgi apparatus
CC and the prevacuolar compartment. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC {ECO:0000305}.
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DR EMBL; CR382137; CAR65842.1; -; Genomic_DNA.
DR RefSeq; XP_002770499.1; XM_002770453.1.
DR AlphaFoldDB; B5RU30; -.
DR SMR; B5RU30; -.
DR STRING; 4959.XP_002770499.1; -.
DR PRIDE; B5RU30; -.
DR EnsemblFungi; CAR65842; CAR65842; DEHA2E16918g.
DR GeneID; 8998776; -.
DR KEGG; dha:DEHA2E16918g; -.
DR VEuPathDB; FungiDB:DEHA2E16918g; -.
DR eggNOG; KOG3511; Eukaryota.
DR HOGENOM; CLU_000700_0_1_1; -.
DR InParanoid; B5RU30; -.
DR OMA; IFMHVTT; -.
DR OrthoDB; 1046610at2759; -.
DR Proteomes; UP000000599; Chromosome E.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
PE 3: Inferred from homology;
KW Glycoprotein; Golgi apparatus; Membrane; Protein transport; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..1570
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /id="PRO_0000407517"
FT TOPO_DOM 25..1390
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 1391..1411
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1412..1570
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 63..72
FT /note="BNR 1"
FT REPEAT 105..116
FT /note="BNR 2"
FT REPEAT 463..473
FT /note="BNR 3"
FT REPEAT 508..518
FT /note="BNR 4"
FT REPEAT 801..812
FT /note="BNR 5"
FT REPEAT 858..869
FT /note="BNR 6"
FT REPEAT 1138..1148
FT /note="BNR 7"
FT REPEAT 1179..1189
FT /note="BNR 8"
FT REGION 1517..1570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1520..1545
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 503
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1009
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1299
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1570 AA; 177947 MW; 5A0B9DD496F72429 CRC64;
MRIELRSWSS IAFLFTLFIA YVVSESNFKP DIKLTKEGEI AKEYNYFDDS SNILVLRKDK
LAISFDDGVS WKNVKETENE RVIRYQFDPF NNNRAFAFTI DKFQYVTNDK GETWSKFEIY
DPKNEKEHLT LNSIPHILFN AKNPDLAIFV VYHCPEDKKI SNQCVNYHFL TTDGFKSNPK
SLQTDASICT FAKSTKSYDV GKDETIYCSR NKLNSFGHIV ESYIVASDDF FKTESKINHA
LAKSGSIIDI RVLQNFAIVV VQNDKFNTKS KVSLLVSKDG KNFNEADLKV DISYGIMTFL
ESSSSSIFLA VMDYSNSFRK FSLSTVYSSD SSGLSFSKVL DKVQGGSIQK VETIDGVWLA
NIADEIKDNK GKSKTLLDML MGGGIDKNIK SRISYNDGED WNLLKINNDG SCTTESECSL
HLLNPTEKSG DGKFVTGPTP GILLSVGNKG SKLEKDINRM NTWISRDGGI SWDFALDEPC
LFSFGDQGNI IVAIPYYGKN KMNSSNMYFS LDQGKSWENV ALEIPIFPLT LTTTVDGTSQ
RFILSGLIDS TPKDKADYSF AETLYAIDFS KAFGGKKCDS KKDFEDIYTR LDPSNDKPIC
IYGHKEKFRR RKQNSQCFVN ELFEDVKVYD DPCECTVIDF ECASGFSRSK EKECKPDKKK
LANICRDKKS KKISLPDKAL ASGNKCKNPK EAAKEFVKTK EFKCSDYLDE DDKDKNKGNK
HDIVSTFNEF DSELQQYTYV EQGETYSGEN IILRTKANVA YASNNGGVEF VKIPVSDEIV
TYYPGLVPGQ VILITDSEKF YFSIDGGNTF QKKTAPAKPN VIGARIISFD KKDTEKFIWY
SSENCDNPFS RDCSLVAYIT EDGGENFQKL KEDVRSCDFV ADVFEDVSDE IKNMIYCTVE
DKSSRKLMLL SSTDYFKQSK KVFDNVVGYA ITGNFLVAAT IDDAEQSLKA KVTVDGQIFA
DADFPPDFHV DSQQAYTVLD SASKAIFIHV TTNNENGHEF GSILKSNSNG TSYSLTLDKV
NRNRIGYVDY DRIEGIEGVI VSNIVANDHS KDRKKLKTQI THNDGGEWSY ITPPVIDSKG
KKYKCNGKSL SKCSLNLHGF TERADYRDTF SSASAIGLMM AVGNVGEYLE DFDKCSTFIS
RDGGITWKEI KKGVYMWEYG DRGTILVLVN AEKTTDKLMY SLDEGDTWHD YKFAEEPIDV
LDLATVPSDT SRKFLIFGKS DRKMVSYSID FTNIHKRQCQ LDLDNPNDDD FEYWSPTHPS
TPDNCLFGRE AKYLRRAIGH DDCFIGSAPL IEGFKVTRNC SCTRKDYECD YNFFRDSDDT
CKLVKGLSPS NRKKEMCKKE NAFEYFEPTG YRKIPLSTCV GGKNFDTWKV HPCPGKQKEF
NKHHGKELNS GSLLAVIGIP IAVFLLATWF VYERGIRRNG GFKRFGQIRL DLDDDDFHPI
ENNEVDKAIN KIVKGGIVIV AASIAGFKTL RKVDRMLFDK VTSSLFRRRP GHRNYVHVPE
MDEEEELFGN FRDNYEEELE EGTNNINEDF NDEPNDYEYE EETNDEVDSR LFNIDDQSDE
ELQSATPEDN
