VPS10_KLULA
ID VPS10_KLULA Reviewed; 1566 AA.
AC Q6CNR4;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 25-MAY-2022, entry version 90.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10;
DE AltName: Full=Carboxypeptidase Y receptor;
DE Short=CPY receptor;
DE AltName: Full=Sortilin VPS10;
DE AltName: Full=Vacuolar carboxypeptidase sorting receptor VPS10;
DE Flags: Precursor;
GN Name=VPS10; OrderedLocusNames=KLLA0E10517g;
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
CC Prevacuolar compartment membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}. Note=Cycles between the Golgi apparatus
CC and the prevacuolar compartment. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC {ECO:0000305}.
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DR EMBL; CR382125; CAG99512.1; -; Genomic_DNA.
DR RefSeq; XP_454425.1; XM_454425.1.
DR AlphaFoldDB; Q6CNR4; -.
DR SMR; Q6CNR4; -.
DR STRING; 28985.XP_454425.1; -.
DR PRIDE; Q6CNR4; -.
DR EnsemblFungi; CAG99512; CAG99512; KLLA0_E10517g.
DR GeneID; 2894257; -.
DR KEGG; kla:KLLA0_E10517g; -.
DR eggNOG; KOG3511; Eukaryota.
DR HOGENOM; CLU_000700_0_0_1; -.
DR InParanoid; Q6CNR4; -.
DR OMA; IFMHVTT; -.
DR Proteomes; UP000000598; Chromosome E.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
PE 3: Inferred from homology;
KW Glycoprotein; Golgi apparatus; Membrane; Protein transport; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..1566
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /id="PRO_0000407519"
FT TOPO_DOM 21..1400
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 1401..1421
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1422..1566
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 60..70
FT /note="BNR 1"
FT REPEAT 418..428
FT /note="BNR 2"
FT REPEAT 496..507
FT /note="BNR 3"
FT REPEAT 542..552
FT /note="BNR 4"
FT REPEAT 767..776
FT /note="BNR 5"
FT REPEAT 864..875
FT /note="BNR 6"
FT REPEAT 1148..1158
FT /note="BNR 7"
FT REPEAT 1190..1199
FT /note="BNR 8"
FT REGION 1534..1566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 796
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1308
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1397
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1566 AA; 176300 MW; 5ECA332332DE8C94 CRC64;
MFWWNILIWL GLWNFLPVLA QDFKPKVSFH SDVDTHGRLS ILGFDDSRVV LKLLRGVELY
RSEDNGVTWD SVGLPLSSDN KPQEWNHLVL DRIYKADVAY LSGENGVLAT GDKGKSWKQL
TFLDADNHKI DFSDYSNVGD ENRKPIINVE IESHPTNKNA RIINIYELGK LDGKFTLRQI
SFYSKDGNNF KLASSGSKSN DDSNPLNMFC SFVQKSSKSK LYKLKDKVIC QESTVLSPFG
DVSSKLYITD VNFKSLSPFA EQLQDLSPAS TFISDNHLFI LTLSDRFNEN SAANLWRLED
DSTDKFEQIS LGTQIRKSLM DVNEIDGRAI ITIYHRERNK DGDNNDDEDK SPFEDIFSGS
IEALISDSYG KNFRHLSFDE QKASSLTLST SIFVKKTMFA TWTNTMRDFG FFDFRSKVSF
DLGNTWSKLK VSDPEGKWNY NCDINSDSND CGFQMFIVYG GGVEGDSDIF SPGIIAAIGD
VYEENPSGDF LKMGTFISRD DGSTWEKVLD FPSRVVMGDY GNIILAVPFD PESDKDPQSE
FYFSLDQGKT FQEYQLDKSF YPTELLPSAL DGSGNSFMLV GTIMSEDYQN LESVSYVVDF
SDAFKGASCK TSDMEDWYYS NGQCVDGTIL KFRRRKQDAQ CLIKTTYKDL TFEEELCGCS
ELDYECADDF SIDSAGKCVP DFSKASLMEK CESKKSIQLE PKKISKTTKC KRPQNIIKEE
ISCAAVPAPS NVKVTENKFS SIFKSYQYFD TFVRESILFR TDKSEAYVSH DGGQNIKQIQ
TGGEDILEIN FNPFFNSSAY LFGKNKNLFA THDYGLSFKV TELPAGRQLG FPLSFHAKDI
QTFIYYGGES CESFFDPNCH AVAYITRDGG ASFEKLLEGA SNCEFLESAV ESPRVENGIV
CMVKDKSTGA RSYVSSTDYF KTQTVLYSDI LGFMSTGGYI VVAVSHGERQ LRAYLTIDGV
EYSEAVLPAD LDSYEQKAFT VLGSQEGAIF MHMTTNLDKN EEFGALLKSN TEGTSFVILE
RAVNRNSFGF VDFEKIQGLE GIILINTVAN AKEIVESKDK TSQKKLKTKI TFNDGADWTY
IKPPSVDSEG KKYNCNPKNL EKCSLNLHGF TERKDVRDTY SSGSAIGYMF ALGNVGEYLT
PVSEASTFMT NDGGISWSEV KKGSYQWEYG DHGSVLVLVK DNEPTDTVSY SINGGKTWKD
YQFASEKINV YDLVTVPRDS AMRFLVIGSS VNVRGEETRT YTLDFVDMFS RQCQYSKDDL
KDFEYISLSH PNTKECLFGH KAKYLRKKSD DCYVGMAPLE DKFRIFANCS CTRNDYECDY
NFMRVSDGTC KLIDGLKPAD PKDICSKDNS LIEYFEPTGY RKIALSTCNG GLMLANSDSP
HPCPGKEKEF KEKYKVNHTS FLAIWIFAVL IFTGMLSFIY YRGIKRNGGF ARFGEIRLGD
DDLIEENNTD RAVNTVLRNG VFLFSNVYTG LQYFGHQVGN FFKRGLSRFG NTTGPSYQSL
LHDQFLDDAD DLLVGHDEDA DDLASFIENE GNFEIGNDEE VDLSSDTPTH APYSDNPEEA
NPHEST
