VPS10_LODEL
ID VPS10_LODEL Reviewed; 1484 AA.
AC A5E1P1;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10;
DE AltName: Full=Carboxypeptidase Y receptor;
DE Short=CPY receptor;
DE AltName: Full=Sortilin VPS10;
DE AltName: Full=Vacuolar carboxypeptidase sorting receptor VPS10;
DE Flags: Precursor;
GN Name=VPS10; ORFNames=LELG_03528;
OS Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC
OS 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade;
OC Lodderomyces.
OX NCBI_TaxID=379508;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11503 / BCRC 21390 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL
RC YB-4239;
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA Birren B.W., Kellis M., Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
CC Prevacuolar compartment membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}. Note=Cycles between the Golgi apparatus
CC and the prevacuolar compartment. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC {ECO:0000305}.
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DR EMBL; CH981527; EDK45349.1; -; Genomic_DNA.
DR RefSeq; XP_001525600.1; XM_001525550.1.
DR AlphaFoldDB; A5E1P1; -.
DR SMR; A5E1P1; -.
DR STRING; 379508.A5E1P1; -.
DR EnsemblFungi; EDK45349; EDK45349; LELG_03528.
DR GeneID; 5232664; -.
DR KEGG; lel:LELG_03528; -.
DR VEuPathDB; FungiDB:LELG_03528; -.
DR eggNOG; KOG3511; Eukaryota.
DR HOGENOM; CLU_000700_0_1_1; -.
DR InParanoid; A5E1P1; -.
DR OMA; IFMHVTT; -.
DR OrthoDB; 1046610at2759; -.
DR Proteomes; UP000001996; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
PE 3: Inferred from homology;
KW Glycoprotein; Golgi apparatus; Membrane; Protein transport; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..1484
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /id="PRO_0000407522"
FT TOPO_DOM 21..1374
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 1375..1395
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1396..1484
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 99..110
FT /note="BNR 1"
FT REPEAT 383..392
FT /note="BNR 2"
FT REPEAT 451..461
FT /note="BNR 3"
FT REPEAT 497..508
FT /note="BNR 4"
FT REPEAT 749..758
FT /note="BNR 5"
FT REPEAT 842..852
FT /note="BNR 6"
FT REPEAT 1116..1126
FT /note="BNR 7"
FT REPEAT 1157..1167
FT /note="BNR 8"
FT CARBOHYD 232
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 986
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1484 AA; 166377 MW; D0F5E51A33D03903 CRC64;
MKWLYNPIVL LAYLFVLSGA AYTPEVRLST HDVLPSAMQY FDDSPTILSL KNDRLWISQD
DGKLFEEVGA TKDQHVVSFQ IDPFLKDRAF VMTNTKTHFY TENQGKSWKK FDAPIYELKE
NGMASVPSIE FNAADSNLLI ISNYQCPDSG KYSHRCEHKY HYTTDGFRSV SKELPIKAHV
CRFARSNPKS QIAKVSSIYC AVNELNSYKH IVQSTLIRSD NFGKDQNVVD LNESGSGAII
DIKVEESFLT VVQKLDKFSE NSKIDMYVSR DGESFFKADL QVDIKYGVMS FLDSSPSSFF
VQTTDYSSKM SDVAKLFRSD SSGVHYKLLL DNIAEGIVMK VENIDGAWLA NTAVDKESDS
DDLNSFLDFL LGGGFAKDIV TKFSFDDGDT WQLLKLNNEK CKLADGCSVH LWSFSEYSGK
GKFVTGPTPG ILMGIGSEGK HLGKYEEMNT YVSRDGGASW DLAIDTPCVF SFGDQGNIIM
AVPYHGVKQE SPANYFYFSL DQGLSWEKVE LEKGIFVLDI LTTLDGTSRK FLIEGVKPEE
GKQGYTRAKE VQYFVDFANV HDGKVCSDSD FEEWTARKID EDSSPTCVYG HREKFRRRKA
DAKCSVDRLF EDIKVIDDPC ECTEADFECS IGFMPSEKGD GQKCVPDPTA IKALCGSSKS
SVLEIYDKTL VQEDKCNMGG RKVDDFATME KFKCSEYNKP GDDNSGEVSK IVVKLNEIEG
RLSQYAYVGT DDDKLADNVV LKTSEDRAYI SNDGGISFVK VPVHDRILGF FTGPVSGQVV
LLTDSEYMYV SQDGGALFER RKIPAELSSQ ISRPIAFHKT DADKFIWIGS DCSKGNCEPV
AYYTTNGGQS FKELMTGAIT CDYVGSVFEQ PEENLVYCTK VEDNNLRSLW SINGQKNPEK
LFDNIVGYAV TGHYVVVAVV QDKSLEAKVT VDGKTFADAD FPNDLKVEAH QAYTVLDSTS
GSIFMHVTTS SKRDFEYGTL LKSNSNGTYF VTSLPNVNRN DVGFVDFDKI EGLEGLIIAN
IVANYKEDKA PKKLQTQVSR NDGSEWGYFI PPPTDSKGVK YKCNGSPLSK CALHLHGFTE
RADYRDTYSS GSATGFLIGV GNVGEYLTDY NEAATFLSID GGVTWKEVQE GVYHWEFGDQ
GTILALVSAN DDTDSIIYSL DEGKTWSEYK FSDKKVKVLD LATVPTDTSR KFLIFAVDPK
DSRETLSFSI DFTNIYARQC QLDLDHPDLD DYEYWSPIHP EGQDKCLFGH EAKYLRRLSN
KNDCFIGSAP LSEAYKQIRV CPCTRRDYEC DYNYVRDPLD NTCKLVPGMS AGDRKKSMCE
KPDAFQYFDS TGYRKIPLST CVGGKQFDKW EPKACPGKQK EFNEYYGRDV KGGKLFILLF
VPIVVFVFAT WFVYDRGIKR NGGFQRLGQI RLDEEDFSDG FHPIEDNKID VVVNRIVKGG
VVVAAGVVAT LKTVRKIDSL LLNKIEMLCL GETRERNYVN IPER
