VPS10_MAGO7
ID VPS10_MAGO7 Reviewed; 1515 AA.
AC A4RF05; G4NBR1;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 25-JAN-2012, sequence version 2.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10;
DE AltName: Full=Carboxypeptidase Y receptor;
DE Short=CPY receptor;
DE AltName: Full=Sortilin VPS10;
DE AltName: Full=Vacuolar carboxypeptidase sorting receptor VPS10;
DE Flags: Precursor;
GN Name=VPS10; ORFNames=MGG_00506;
OS Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast
OS fungus) (Pyricularia oryzae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Magnaporthales; Pyriculariaceae; Pyricularia.
OX NCBI_TaxID=242507;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=70-15 / ATCC MYA-4617 / FGSC 8958;
RX PubMed=15846337; DOI=10.1038/nature03449;
RA Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K.,
RA Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D.,
RA Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S.,
RA Soanes D.M., Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M.,
RA Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E.,
RA Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W.;
RT "The genome sequence of the rice blast fungus Magnaporthe grisea.";
RL Nature 434:980-986(2005).
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Prevacuolar
CC compartment membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250}. Note=Cycles between the Golgi apparatus and the
CC prevacuolar compartment. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC {ECO:0000305}.
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DR EMBL; CM001235; EHA48969.1; -; Genomic_DNA.
DR RefSeq; XP_003718553.1; XM_003718505.1.
DR AlphaFoldDB; A4RF05; -.
DR SMR; A4RF05; -.
DR STRING; 318829.MGG_00506T0; -.
DR PRIDE; A4RF05; -.
DR EnsemblFungi; MGG_00506T0; MGG_00506T0; MGG_00506.
DR GeneID; 2674786; -.
DR KEGG; mgr:MGG_00506; -.
DR VEuPathDB; FungiDB:MGG_00506; -.
DR eggNOG; KOG3511; Eukaryota.
DR HOGENOM; CLU_000700_0_0_1; -.
DR InParanoid; A4RF05; -.
DR OMA; ATMSEFI; -.
DR OrthoDB; 1046610at2759; -.
DR Proteomes; UP000009058; Chromosome 5.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
PE 3: Inferred from homology;
KW Glycoprotein; Golgi apparatus; Membrane; Protein transport; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..1515
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /id="PRO_0000407523"
FT TOPO_DOM 25..1370
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 1371..1391
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1392..1426
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 1427..1447
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1448..1515
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT REPEAT 64..73
FT /note="BNR 1"
FT REPEAT 107..117
FT /note="BNR 2"
FT REPEAT 449..458
FT /note="BNR 3"
FT REPEAT 491..500
FT /note="BNR 4"
FT REPEAT 739..749
FT /note="BNR 5"
FT REPEAT 836..845
FT /note="BNR 6"
FT REPEAT 1040..1050
FT /note="BNR 7"
FT REPEAT 1120..1130
FT /note="BNR 8"
FT REPEAT 1161..1170
FT /note="BNR 9"
FT REGION 673..698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1494..1515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 684..698
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1501..1515
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 333
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 692
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 699
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 988
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1173
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1227
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1347
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1515 AA; 169648 MW; 0B20B07BAC422678 CRC64;
MRLGAALQAA ALLTASLWSH PLLAASDDPA FKTTKLDHYP FNLNYFEDSD IVLYQDEARG
TISRSEDAGA TWTLVKDIEE GKAFQLVMHP FDRKRAYVLT SPGIHHFRTH DQGRTWQDFL
ADTEMTMFRL DILSFHATDP DRIIFNGMDC KEGKFFCEEV AMYTTDGFTS DAKFLRGSTS
GCSWAKSSKL FTTGQDDLDK NRILCVVRDH FSPLKQDQRL MISDNFFSAK DAGGVIQEFE
PNLDMTRPIQ GVVNVAVVKK YLLVAASSMN TDEMSLFVSD DTLKWHRAMF PTDHKINQES
YTVLESTEYS IQVDVMTTHP SNPMGVMYTS NSNGTFFTRN IEHTNRNHRG HVDFEKITGV
QGIFMVNKVD NAEEVEKDRR GKKKIVSEIT FDDGRTFEPI HADKERLHLH SVTELINAGR
VFSSPAPGLV MGNGNTGKHL ESWKDASLYI SDDAGLTWIK GPNGPHKYEF GDQGSVLLAV
MQAEEVDEVK YSLNHGKDWK TAKLPDDLKV KPIILTTTQD STSLKFILIG EGKGRDEFHI
VAIDFSSMHE ATCKDSDMED WYARVDDKGK ATCLMGHTQK YRRRKKDADC FVKQEFKDPV
PETKDCECSD QDFECDYNFK RDGKECVLVG TVVAPDGACK NAGPDDTFKG SSGWRLIPGN
TCKRASGAQK DDLVDRKCKE TSEPTPSEPS GNISTTPHNF SGDWLDFEKH YLEKGAESMD
ENEVVIARPI NAQNAGQIFL TKDHGKTWHM PEALKDKNIW GIVTHQYFKE MAFFVQDTGS
VIYTVDHGEH FHDFKAPGNG IDPDTKPLVF HPDHKDWMIW IGKKCEENTC YREASFSQDR
GDNWKSIARY VYKCEFTGSS SYKFRSQDQI ICSIQSREGN EKNIPFDLVS SNDLFKTSEV
RQKNIKDFAT MAEFIVVAAE DPERKSLKAF ASLDGDSYAA TRFPSNLDVK EERAFTILDS
STHAVKLFVP SPAQKDRCVG SIAKSNSNGT DYVVSITGVN CDENYFVDFE KMLTLEGVIL
VNIVANRENT NEPKKRRSLI SHSDGATWSY LPPPRVDAEG KNYPCTSSDN GDENCALHIH
GYTERKDHGK TYSSAGAVGL MFGVGNVGST LGDIKDADTF LTTDAGISWK SVKKGAWRWA
YGDQGSILML VPSTKTKMVS YTTDEGETWN DHNFTDEPVD VLDMTTVSSG GSRNFLLWCR
RSDKTVFAVN LDLTGLANTA CKQVDDNDSE SDYYAWSPSH PLRPDDCLFG HKSYYLRKKT
DRKCYNKHKI TPVFKMDVCE CTREDFECDY NYELEGVGRN CVLAKGAQPM SREDWCSAHP
KESTWYEPSG FRRIPISTCK EGRVFDNYTT SWPCPGHEEE YERQHGGPGG FTIFLIVILC
VGAAGAVGVW VHRRWESGGF GQIRLGEQSS SGISFLDPDS PWVRYPVVAV SATVALVGAL
PLLVGALWRT TKTTVERWGI FGGVGRGTYG SLGLGGGSGA RRFTTRDSFA RGRSDYAGID
EDEGELLGDD SDEEV
