VPS10_NEOFI
ID VPS10_NEOFI Reviewed; 1487 AA.
AC A1DAY6;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 25-MAY-2022, entry version 80.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10;
DE AltName: Full=Carboxypeptidase Y receptor;
DE Short=CPY receptor;
DE AltName: Full=Sortilin vps10;
DE AltName: Full=Vacuolar carboxypeptidase sorting receptor vps10;
DE Flags: Precursor;
GN Name=vps10; ORFNames=NFIA_096480;
OS Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=331117;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181
RC / WB 181;
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Prevacuolar
CC compartment membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250}. Note=Cycles between the Golgi apparatus and the
CC prevacuolar compartment. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC {ECO:0000305}.
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DR EMBL; DS027694; EAW20026.1; -; Genomic_DNA.
DR RefSeq; XP_001261923.1; XM_001261922.1.
DR AlphaFoldDB; A1DAY6; -.
DR SMR; A1DAY6; -.
DR STRING; 36630.CADNFIAP00008901; -.
DR PRIDE; A1DAY6; -.
DR EnsemblFungi; EAW20026; EAW20026; NFIA_096480.
DR GeneID; 4588488; -.
DR KEGG; nfi:NFIA_096480; -.
DR VEuPathDB; FungiDB:NFIA_096480; -.
DR eggNOG; KOG3511; Eukaryota.
DR HOGENOM; CLU_000700_0_0_1; -.
DR OMA; ATMSEFI; -.
DR OrthoDB; 1046610at2759; -.
DR Proteomes; UP000006702; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
DR SUPFAM; SSF50939; SSF50939; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Golgi apparatus; Membrane; Protein transport; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..1487
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /id="PRO_0000407525"
FT TOPO_DOM 23..1356
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 1357..1377
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1378..1404
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 1405..1425
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1426..1487
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT REPEAT 61..71
FT /note="BNR 1"
FT REPEAT 378..387
FT /note="BNR 2"
FT REPEAT 438..448
FT /note="BNR 3"
FT REPEAT 479..489
FT /note="BNR 4"
FT REPEAT 721..731
FT /note="BNR 5"
FT REPEAT 816..826
FT /note="BNR 6"
FT REPEAT 1104..1114
FT /note="BNR 7"
FT REPEAT 1145..1155
FT /note="BNR 8"
FT CARBOHYD 300
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 324
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 967
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1265
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1487 AA; 166455 MW; C8197C910E5F1CB0 CRC64;
MITRWLLITS FLALAILSLS SAAKKSEPEI TPSSFDNEPF SLFYFEDTET ILMNTRDGNL
FRSFDGGKGW EQVDDPNGKM KKGVRSIWQH PFDKNRAYAL GANRRHWVTK DQAKTWESFE
VDGYAATQHE PLIFHGWDSS KVIFQSDECM GRFCIVKSYY STDDFKTVSP LRVSAGGCAW
AVGHPQFAEG LNLEDELRDR VLCIVPGLKV PSAHANRLVY SDDFFRSDAE GTELNIQQGR
PVSGILSAAA VKKFFVTAAK SQGTNELALY VTLDTKAWHR ADFGGHRVEQ DGYTLLESTN
YSMQVDVLTS PSSNTGILFT SNSNGTYFTR NVEHTNRDRF GHVDFEKIAD IQGIVLVNTV
KNWDKVGSEN EKKVVSSISF DDGRTFQSLK VGDKQLHLHS VTTFANTGRV FSSPAPGLVM
GVGNTGDHLK KYSEGSLYVS DDAGVTWRHA LDGPFKYEFG DQGSVIMAVS DKGTTDEIQF
SIDHGKEWHS TKLQHKIYPK LLTTTPDSTS LTFLLVGSEE SSGTKHVVYS IDFRGLHERK
CEKDDFEKWA ARLNENGEPD CLMGHQQFFN RRKANADCFV DEEFKDPQPI FEPCKCSFED
FECDFNFVRS EDGKSCVPAA PLVPPVGRCQ KQTDTFMGPS GWRLIPGNTC TREGGENLDK
DVERPCKDVV SAPSHDKLMA QKQVFNDARQ FSEQYYYLER QASSSGDDET VIMLTSEGEF
WVSHDHGKNW EQPLKGVKIA AIVPHPYYSD GAFLLTRDKQ AFWTVDRAYT FKSFEAPIPP
NQEGLPVLSF HPQYKDWLIW TGAVDCAHGD CHSDAYFSKN RGENWDLLLR YVGKCEFESR
ENRPGSEKLI FCQQYENENK KNHLQLLSSE NLFSDSHVHF NDAIRYATMS EYIIVASRDP
DNPDSLVASV SVDGRTFARA EFPPNVDVPV KTAFTVLDSS THAVFLHVTV SDVKGAEHGS
IIKSNSNGTS YVLSLNAASR NEWGYVDFEK MQGLEGVAVV NIISNVEAVL KKGPTAKKLK
TMITHNDGGQ WMLLPPPAKD ADGKNFGCSV KGGKGSGQCS LHLHGYTERR DPRDTFSSGS
AIGLMMGIGN VGAHLSGKDE ADTFMTRDGG ITWKSVKKGR YMWEYGDSGS VIVIVPELRP
TKVLYYSLDE GDNWEPYEFS EVEMHIYRLS TVPSDTSKNF LLWGKEVESN RLATINVDFS
GLRKKSCNLV ENGQESDDYY LWEPKHPFQE DNCLFGHVEQ YHRKKPSSQC WNNWREPHVH
SIGRNCTCTR ADYECNYNYE PQNDGSCALV PGLPKPDALA VCREDPDRVE YWEPTAYRRI
PQTTCAGGLI LDHVVSKPCP SKEKEYEKKH GISGTGLFFA IMIPIVAAAG VGYYVYAKWD
GKFGQIRLGE NAGTYEGLLS RESPIVTVPI AVIAGIVAVI RALPLLAMSL WRSASGYVRL
GRNRAYSRPY ASRGSFAARR GDYTSVVDDE DELLGVDDAE IDEDDEL
