VPS10_PARBA
ID VPS10_PARBA Reviewed; 1496 AA.
AC C1GTA5;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 26-MAY-2009, sequence version 1.
DT 25-MAY-2022, entry version 58.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10;
DE AltName: Full=Carboxypeptidase Y receptor;
DE Short=CPY receptor;
DE AltName: Full=Sortilin VPS10;
DE AltName: Full=Vacuolar carboxypeptidase sorting receptor VPS10;
DE Flags: Precursor;
GN Name=VPS10; ORFNames=PAAG_01750;
OS Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides
OS brasiliensis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX NCBI_TaxID=502779;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-826 / Pb01;
RX PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT "Comparative genomic analysis of human fungal pathogens causing
RT paracoccidioidomycosis.";
RL PLoS Genet. 7:E1002345-E1002345(2011).
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Prevacuolar
CC compartment membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250}. Note=Cycles between the Golgi apparatus and the
CC prevacuolar compartment. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC {ECO:0000305}.
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DR EMBL; KN293994; EEH39288.1; -; Genomic_DNA.
DR RefSeq; XP_002796742.1; XM_002796696.2.
DR AlphaFoldDB; C1GTA5; -.
DR SMR; C1GTA5; -.
DR STRING; 502779.C1GTA5; -.
DR EnsemblFungi; EEH39288; EEH39288; PAAG_01750.
DR GeneID; 9099708; -.
DR KEGG; pbl:PAAG_01750; -.
DR VEuPathDB; FungiDB:PAAG_01750; -.
DR eggNOG; KOG3511; Eukaryota.
DR HOGENOM; CLU_000700_0_0_1; -.
DR OMA; ATMSEFI; -.
DR OrthoDB; 1046610at2759; -.
DR Proteomes; UP000002059; Partially assembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 3.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
PE 3: Inferred from homology;
KW Glycoprotein; Golgi apparatus; Membrane; Protein transport; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..1496
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /id="PRO_0000407527"
FT TOPO_DOM 22..1362
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 1363..1383
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1384..1409
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 1410..1430
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1431..1496
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT REPEAT 61..71
FT /note="BNR 1"
FT REPEAT 377..387
FT /note="BNR 2"
FT REPEAT 438..448
FT /note="BNR 3"
FT REPEAT 480..489
FT /note="BNR 4"
FT REPEAT 722..732
FT /note="BNR 5"
FT REPEAT 819..829
FT /note="BNR 6"
FT REPEAT 1106..1116
FT /note="BNR 7"
FT REPEAT 1147..1157
FT /note="BNR 8"
FT CARBOHYD 190
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 297
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 322
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 971
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1496 AA; 167980 MW; A4205B733791F860 CRC64;
MILRRLVLAG SLLLATAFTS AKKADSPIIT ATRFDHEPIN LFYFGDSDVV MLQDIKNGDV
YVSRDAGVKW DMVNLDGLKG QALSLWSHPT DRTKAYILGK AGKHWVTNDQ AKSWHEFSAD
VEFFQSLYPL VFHGKDSDRV LLQGQKCFGR DCKEVTYYTT DGFKTVDILM ENARGCNWAV
STPIFGDGLN LSKEVNDRIF CIVPGLQSPW SDYNRLLYSD RFFKQDPGTE APLDSGRAVS
GVVRTASVKK YLLAAAKSAR TSELALYVTD DGSQWHRAEF DGHRVEEDAY TVLESTNYSI
QIDVVAETPS APMGRLFTSN SNGTYFTRNI DHTNRNSLGF VDFEKIANIQ GIILVNTVKN
WEDVEMSALV EKKIISQISF DDGRTFQPLK AGKHDLHLHS VTHLSNSGRV FSSPAPGLVM
GVGNTGGHLK DYYDGDLYVS DDAGITWRKA LDEAHKYEFG DQGSVIVAIF DEGRTGKISY
SLNHGKDWKE ASLPDGIKIR ARILTTMPDS TGLKFLLVGS AKKDSEVEHY VISISFTDME
ERTCGKDDFE TWPARLNEKN EPDCLMGHKQ FYQRRKADVD CFIKKKFQEP VPQFEPCKCT
VEDFECDFNF IRSTDGKSCV PARNLPVPEG ACKKPDDKYM GSSGFRLIPG NACIREGGVE
LDKQIERVCT DTLTVPVSGE IAVQKTFFTA DNYKGYFYLE RKDSSKGDDE TVIMITSELQ
IYITRDHGKI WKEIFPGESI TRIVPHQYFD DVAYFLTNSG DGWYTLDRGE NFRTFKVPIP
PNQDKLPVLS FHPERRDWLI WTGAVECKTR GPQCHSVAYY STNHGSEWHF LMQYVRRCEF
IKREARGSSN NLVFCEQFEN ENPLNHHLQL LSTDDWFSEK KVHYNNILDF ATMQEFIIVA
VRGEKPQDSL SVGVSVDGET FAYADLPANV QIPVQRAYTV LESRTHAAFL HVTVNNIEDH
EYGSILKSNS NGTSYVLSLS AVNRNTYGYA DFEKMQGMEG VAMANVVGNV ADVEKGAAKK
YRTMITHNDG AEWTLLSPPS KDSEGRDYSC STKGGKPTDK CALHLHSYTE RVDPRDTYSS
PAAIGVMLGT GNVGEYLTLK SEADTFITRD GGITWEEVKK DKYQWEFGDS GSIIVIVPES
RPTKTLFYSL DEGKSWKEFQ FSEVEMLIRD ISTVPSDTSR NFLLWGNEVG NGKKPGIATV
NVDFSNLKER HKQCVLNEEK PEADDYYLWE PIHPFQPNGC LFGHRAKYHR KRPDRDCFIG
RELQHLDSIG DICECTRSDY ECDYNYEPQI DGTCAPVPGL QPLDPKLICM EDPKAVEWYE
PTGYRRIPLT KCEGGKQLHH IIPHACPNKE EEFLKKHPGL RGVGLFFVVM GPIGLAAAIG
YYVYTRWDGK FGRIRLGDTG SGGFFASDSL FISIPVAIVA GVVAVATALP LLASSLWRSV
KGYARVPGGS SSQRVYSSRA AFAAQRADYV GVVDDEDELL GAEDFDEEEN DDRGQV
