VPS10_PARBD
ID VPS10_PARBD Reviewed; 1496 AA.
AC C1FZI7;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 26-MAY-2009, sequence version 1.
DT 25-MAY-2022, entry version 53.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10;
DE AltName: Full=Carboxypeptidase Y receptor;
DE Short=CPY receptor;
DE AltName: Full=Sortilin VPS10;
DE AltName: Full=Vacuolar carboxypeptidase sorting receptor VPS10;
DE Flags: Precursor;
GN Name=VPS10; ORFNames=PADG_00027;
OS Paracoccidioides brasiliensis (strain Pb18).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX NCBI_TaxID=502780;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pb18;
RX PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT "Comparative genomic analysis of human fungal pathogens causing
RT paracoccidioidomycosis.";
RL PLoS Genet. 7:E1002345-E1002345(2011).
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Prevacuolar
CC compartment membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250}. Note=Cycles between the Golgi apparatus and the
CC prevacuolar compartment. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KN275957; EEH43738.1; -; Genomic_DNA.
DR RefSeq; XP_010756170.1; XM_010757868.1.
DR AlphaFoldDB; C1FZI7; -.
DR SMR; C1FZI7; -.
DR STRING; 121759.XP_010756170.1; -.
DR EnsemblFungi; EEH43738; EEH43738; PADG_00027.
DR GeneID; 22579932; -.
DR KEGG; pbn:PADG_00027; -.
DR VEuPathDB; FungiDB:PADG_00027; -.
DR eggNOG; KOG3511; Eukaryota.
DR HOGENOM; CLU_000700_0_0_1; -.
DR OMA; ATMSEFI; -.
DR Proteomes; UP000001628; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
PE 3: Inferred from homology;
KW Glycoprotein; Golgi apparatus; Membrane; Protein transport; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..1496
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /id="PRO_0000407528"
FT TOPO_DOM 22..1362
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 1363..1383
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1384..1409
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 1410..1430
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1431..1496
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT REPEAT 61..71
FT /note="BNR 1"
FT REPEAT 377..387
FT /note="BNR 2"
FT REPEAT 438..448
FT /note="BNR 3"
FT REPEAT 480..489
FT /note="BNR 4"
FT REPEAT 722..732
FT /note="BNR 5"
FT REPEAT 819..829
FT /note="BNR 6"
FT REPEAT 1106..1116
FT /note="BNR 7"
FT REPEAT 1148..1157
FT /note="BNR 8"
FT CARBOHYD 190
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 297
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 322
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 971
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1496 AA; 167828 MW; A27C3AFB64334C43 CRC64;
MILRRLVLAG SLLLATAFTS AKKADSPIIM ATRFDHEPIN LFYFGDSDVV MLQDIKNGDV
YVSRDAGVKW DMVNLDGLKG QALSLWSHPT DRTKAYILGK AGKHWVTNDQ AVSWHEFSAD
VEFFQSLFPL VFHGKDSDRV LLQGHKCVGR DCKEVTYYTT DGFKTVDILI ENARGCNWAV
STPIFGDGLN LSKEVNDRIF CIVPGLQSPW SDYNRLLYSD RFFKQDSGTE APLDSGRAVS
GVVRTASVKK YLLAAAKSAR TSELALYVTD DGSQWHRAEF DGQRVEEDAY TVLESTNYSI
QIDVVAETPS APMGTLFTSN SNGTYFTRNI DHTNRNGLGF VDFEKIATIQ GIILVNTVKN
WEDVEMSALV EKKIISQISF DDGRTFQPLK AGKHDLHLHS VTHLSNSGRV FSSPAPGLVM
GVGNTGGHLK DYYDGDLYVS DDAGITWRKA LDEAHKYEFG DQGSVIVAVF DEGRTGKISY
SLNHGKDWKE ASLPDGIKIR ARILTTMPDS TGLKFLLVGS SKRDSDVEHY VISISFTDME
ERTCGKDDFE TWPARLNEKN EPDCLMGHKQ FYQRRKADVD CFIKKKFQEP VPQFEPCKCT
VEDFECDFNF IRSTEGKSCV PARSLPVPEG ACKKPNDKYM GSSGFRLIPG NACIREGGVE
LDKQIERVCT DTLTVPVSGE IVVQKTFFTA DNYKGYFYLE RKDSSKGDDE TVIMITSELQ
IYITRDHGKN WKEIFPGETI TRIVPHQYFD DVAYFLTNSG DGWYTLDRGE NFRKFKAPIP
PNQDKLPVLS FHPERRDWLI WTGAEECKTR GPQCHSVAYY STNHGSEWHF LMQYVRRCEF
IKREARGSSN NLVFCEQFEN ENPLNHHLQL LSTDDWFSEK KVHYNNILDF ATMQEFIIVA
VRGEKPEDSL SVGVSVDGET FAYADLPANV QIPVQRAYTV LESRTHAAFL HVTVNNVEDH
EYGSIIKSNS NGTSYVLSLS AVNRNTYGYA DFEKMQGMEG VAMANVVGNV ADVEKGAAKK
YRTMITHNDG AEWALLSPPS KDSEGRDYSC STEGGKPTDK CALHLHSYTE RADPRDTYSS
PSAIGVMLGT GNVGEYLTLK SDADTFITRD GGITWQEVRK DRYQWEFGDS GSIIVIVPES
RPTKTLLYSL DEGKSWKEFQ FTEVEMLIRD ISTVPSDTSR NFLLWGNEVG NGKKPGVAAV
NIDFSNLKER HKQCVLNEEK PEADDYYLWE PMHPFQPNGC LFGHRAKYHR KRPDRDCFIG
RELQHLDSIG DICECTRSDY ECDYNYEPQI DGTCAPVPGL KPLDPKLICT EDPKAVEWYE
PTGYRRIPLT KCEGGKQLHH IIPHACPNKE EEFLKKHPGL RGVGLFFVIM SPIGLAAAIG
YYVYTRWDGK FGRIRLGDTG SGGFFASDSL LISIPVAIVA GVVAVATALP LLASSLWRSV
RGYARVPGGS SSQRVYSSRA AFAAQRADYV GVVDDEDELL GAEDFDEEEN DDRGQV
