VPS10_PENRW
ID VPS10_PENRW Reviewed; 1489 AA.
AC B6H711;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 1.
DT 03-AUG-2022, entry version 60.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10;
DE AltName: Full=Carboxypeptidase Y receptor;
DE Short=CPY receptor;
DE AltName: Full=Sortilin vps10;
DE AltName: Full=Vacuolar carboxypeptidase sorting receptor vps10;
DE Flags: Precursor;
GN Name=vps10; ORFNames=Pc16g01030;
OS Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS 54-1255) (Penicillium chrysogenum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC Penicillium chrysogenum species complex.
OX NCBI_TaxID=500485;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255;
RX PubMed=18820685; DOI=10.1038/nbt.1498;
RA van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA Bovenberg R.A.L.;
RT "Genome sequencing and analysis of the filamentous fungus Penicillium
RT chrysogenum.";
RL Nat. Biotechnol. 26:1161-1168(2008).
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Prevacuolar
CC compartment membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250}. Note=Cycles between the Golgi apparatus and the
CC prevacuolar compartment. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC {ECO:0000305}.
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DR EMBL; AM920431; CAP92773.1; -; Genomic_DNA.
DR RefSeq; XP_002560521.1; XM_002560475.1.
DR AlphaFoldDB; B6H711; -.
DR SMR; B6H711; -.
DR STRING; 1108849.XP_002560521.1; -.
DR EnsemblFungi; CAP92773; CAP92773; PCH_Pc16g01030.
DR GeneID; 8315370; -.
DR KEGG; pcs:Pc16g01030; -.
DR VEuPathDB; FungiDB:PCH_Pc16g01030; -.
DR eggNOG; KOG3511; Eukaryota.
DR HOGENOM; CLU_000700_0_0_1; -.
DR OMA; ATMSEFI; -.
DR OrthoDB; 1046610at2759; -.
DR BioCyc; PCHR:PC16G01030-MON; -.
DR Proteomes; UP000000724; Contig Pc00c16.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
PE 3: Inferred from homology;
KW Glycoprotein; Golgi apparatus; Membrane; Protein transport; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..1489
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /id="PRO_5000409175"
FT TOPO_DOM 24..1362
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 1363..1383
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1384..1410
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 1411..1431
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1432..1489
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT REPEAT 63..72
FT /note="BNR 1"
FT REPEAT 387..396
FT /note="BNR 2"
FT REPEAT 454..464
FT /note="BNR 3"
FT REPEAT 495..505
FT /note="BNR 4"
FT REPEAT 738..747
FT /note="BNR 5"
FT REPEAT 1118..1128
FT /note="BNR 6"
FT REPEAT 1160..1169
FT /note="BNR 7"
FT CARBOHYD 306
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 331
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 684
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 862
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 925
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 982
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1272
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1489 AA; 167525 MW; 50B065ABEBCB4993 CRC64;
MIPRWLLLTL SLLLVWASHP AAAKGNEPNI VTHELDAPPA DLFYFHGTNT ILYRDRRSLT
AHVSFDGGEE WETVKGNDGT IEGTVDLIWR HPFDDNRAYI LGENGKHWIT TDQAKSWRPF
QVDVLPFASM RSFPLEFNGW DPKKVIFMGL DCTILGCLPQ TFYTTDDFET VKPLREMTLQ
CMWAASRPQF ALDIDMPKST GDRILCVVPG LKGPFEHTRT ERLIYSDSFF KDDAEGTEAK
LDHGKPLSGV SLQIRSVSKY IVARLQSRGT QEQALYVSDD SNVWHRAEFG KHRIEEDAYT
ILESTNYSIQ IDVQTTWQDN RMGSLFSSNS NGTYFTQNIE HTNEDLNGLV DFERVTGIHG
ITIVNTVKNW EEAKKSDSNK KKLISSISFD DGRTFQPLKA DKDELHLHSM TTYAALHEMP
LPDHRMFSSP APGLVMGVGN TGGHLEDYSK GDLYVSDNAG LTWRRALKGP HRYEFGDQGG
VITAVLDSSQ TDKVQFSIDH GKEWESISLG QKIRPLFLVS TPDSTSLKFL LVGTSSDDTT
KTLMFFIDFD GLHERECGSG DLEEWTARLN EKGEPDCLMG QKQFFQRRKA NADCFIKKEF
AISGPEFQLC KCSAEDFECD YNFVRSEDRK ECVPAVPLTP PAGKCKDPSD KYMGPSGWRL
IPGNACIREG GEDLEREIER SCSNVTGPPL ITDGKPRAGK PQTISAKWTN YFYLERQASN
NGVDETIMML TDKYELHVSR DHGRNWKQIH PDEKFIEMVQ HPYFSDTAFF LTDGKRVYYT
INHGDSFHFF DAPSVPNKEY IRKLAFHEKF QDSLIWIGHK DCEGKNCRSQ AYVTDKRGAS
WEPMLIGIAD GGCNFGYQEG RNNSEKLVIC EQYKDEEKNN NRQLVISDDY FSTMEVKFEN
IARSATKNGF EVVAWYEGDQ KEYLNASVSV DGRTYANAHF PFNIKVPQYT VLPSSPHALF
LLVMVNGGGE RSFGSLVKSN SNGTYFVQSL EGLNVNDRGY TDYDELQGLE GVAIANVVSN
REEVLNKGAA KKLRTMITHN DGGQWMLLAP PSKDVDGKNF DCSVTEGKGT EKCALHFHGY
TERRDYRDTL YSGSAIGLML ALGNVGEHLT SASEADTYLT RDGGISWTQV KKGQYMWEFG
AAGSVIVLVS DRKATKVVHY TLDEGMSWHE FQFAEKELVI DDISTVPSDT SKKFLLWGID
GGKRVIVTLD FSGIWSRDCN DDESDYYNWA PTHPFQEENC IFGHVEEYHR KKPAAECWNA
WREPHIHSIG RNCTCTRADF ECDYNYEIQT DGSCGLVPGL QPQDHVAQCS QDPDKVEYWE
PTGYRRIPQT TCEGGLLLDQ DVSKPCPNKE EEYQKKHGIS GTGLFFAIVT PIAVAVAVGW
YAYTHWDGKF GQIRLGDSGG SQSWLSRDSM LVAVPVALIA GIVAVAQSLP LLVKSLARSS
SGLFGRRGMQ RPYATRGSFA ARRGDYSSVV DDEDELLGAD DFDDEEDQA
