VPS10_PHANO
ID VPS10_PHANO Reviewed; 1421 AA.
AC Q0TVB2;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 2.
DT 25-MAY-2022, entry version 76.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10;
DE AltName: Full=Carboxypeptidase Y receptor;
DE Short=CPY receptor;
DE AltName: Full=Sortilin VPS10;
DE AltName: Full=Vacuolar carboxypeptidase sorting receptor VPS10;
DE Flags: Precursor;
GN Name=VPS10; ORFNames=SNOG_16552;
OS Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume
OS blotch fungus) (Parastagonospora nodorum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Phaeosphaeriaceae;
OC Parastagonospora.
OX NCBI_TaxID=321614;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SN15 / ATCC MYA-4574 / FGSC 10173;
RX PubMed=18024570; DOI=10.1105/tpc.107.052829;
RA Hane J.K., Lowe R.G.T., Solomon P.S., Tan K.-C., Schoch C.L.,
RA Spatafora J.W., Crous P.W., Kodira C.D., Birren B.W., Galagan J.E.,
RA Torriani S.F.F., McDonald B.A., Oliver R.P.;
RT "Dothideomycete-plant interactions illuminated by genome sequencing and EST
RT analysis of the wheat pathogen Stagonospora nodorum.";
RL Plant Cell 19:3347-3368(2007).
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Prevacuolar
CC compartment membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250}. Note=Cycles between the Golgi apparatus and the
CC prevacuolar compartment. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC {ECO:0000305}.
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DR EMBL; CH445374; EAT76092.2; -; Genomic_DNA.
DR RefSeq; XP_001806659.1; XM_001806607.1.
DR AlphaFoldDB; Q0TVB2; -.
DR SMR; Q0TVB2; -.
DR STRING; 13684.SNOT_16552; -.
DR EnsemblFungi; SNOT_16552; SNOT_16552; SNOG_16552.
DR GeneID; 5983591; -.
DR KEGG; pno:SNOG_16552; -.
DR eggNOG; KOG3511; Eukaryota.
DR HOGENOM; CLU_000700_0_0_1; -.
DR InParanoid; Q0TVB2; -.
DR OrthoDB; 1046610at2759; -.
DR Proteomes; UP000001055; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0006895; P:Golgi to endosome transport; IBA:GO_Central.
DR GO; GO:0006896; P:Golgi to vacuole transport; IBA:GO_Central.
DR GO; GO:0006892; P:post-Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 3.
DR SMART; SM00602; VPS10; 2.
DR SUPFAM; SSF50939; SSF50939; 2.
PE 3: Inferred from homology;
KW Glycoprotein; Golgi apparatus; Membrane; Protein transport; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..1421
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /id="PRO_0000407531"
FT TOPO_DOM 22..1296
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 1297..1317
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1318..1349
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 1350..1370
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1371..1421
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT REPEAT 100..110
FT /note="BNR 1"
FT REPEAT 367..376
FT /note="BNR 2"
FT REPEAT 415..425
FT /note="BNR 3"
FT REPEAT 671..682
FT /note="BNR 4"
FT REPEAT 1049..1059
FT /note="BNR 5"
FT REGION 596..625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 599..622
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 288
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 922
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1212
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1421 AA; 160204 MW; 59CBF8AE5654D936 CRC64;
MKYLKGLLLP ALLALAPSAT AAKDAPSIET TTFSNELVNL QYFDDSTVAL VQELGSGKIY
RSPDAGKAWK ELKDLKKGLG IIKNPYDNKV ALVLGEEQHW ITYDQGETWQ DFKTEYSPSP
NGPVSWHSQD NKKILIHEIE DCLFTPCLGL TYYTTDGFKT KPKTLVEGRR MCQWAKGSER
FLEGQEKHDD RILCILRGKY SDRSKDFRLM ISDDYFKTAE EPVMSSGRTV QGMANMAAVK
GYLVAAVKAD HSSELSLYVT QDTENWHHAQ FGNGKIEEDA YTILESTNYS IQVDVMSSKY
VSIGSLYTSN SDGLYFTKNV DNTNRNPDGF VDFEKIANIQ GVVLVNIVDN AKAVQERGAH
KKLKSRISFD DGRTFEELKV KGSDKELHLH SSPGIVMGVG NTGDELGKYT DGDLYVSDDA
GLTWELALDE AHKYEFGDQG SVLVAVFDEG DTDKVMYSLK HGRKDTWKSI DLGYKIRARE
LTTLSDSTSL RFLLYGSKKK DGGGREHVLI QLDFNDLHER KCEDKDFDPK WSDPTPTFES
CECDEFRDFE CDFGFKPEGE GKDKKCVPEK LTLPKDACKN GDSTYMGSSG WRKISGNQCK
GGSKKDEKTE RKCDEADLPP PKSDKITSEI TRFKGSNFLE QYYLERSTQN DDDETDHDET
VVMLTDERTA WITHDHGKQW KKAVDDEVVR IYPHQYDNNY VYFLTASKKV HYSEDRGLRN
SIHSFEAPVM PNQEMLQILQ FHPKQKGWLI WMGGKNCEKV NSKECHTAAY VSQKNGKDES
WEPLVSYVKK CAFVWREAGR DVKEERVFCE QHANEETGAP LQLISSDDWF KKQDVKFKSV
VEIALMSEFI IVATKEKDDT LRLDASLDAN TFAEARFPPK FFDIHQTAYT VLDSSTHAIF
LHVTVNPRVD QEYGSIIKSN SNGTSYVLSL NAVNRNTEGY VDFEKMQGLE GVAIANVVVN
VNEVNDGAKK KKQTRITHND GADWREKDAE GKAYECAGKG EEKCALHVHG YTERADPREM
YSSPTAVGLM LAVGNVGEEL GTFGEADTYM TTDAGLTWKE IKKGSYAWEF GDQGSVIVIV
RRGEDTDHVY YTLDSGEKWN LYQFSERKIR VDAITTVPSD TSLNFLLWGK DGKELVAVNL
DFSGLPQFQR KCDLDEKDPE KGDFDLWIPQ HPLQPDDKQC LFGHVAEYHR KKRDAECRNG
QRIDHMHNIQ RNCTCTRRDY ECAYNYERQP GGECKLIEGL DLEDPTAVCS KGAKEFWDVS
PYRKIPLSTC EGGNEFDHMG DVHPCPGFEE EFEKKHGISG FGLFMAIVLP FAAAGGIGYY
VWRNWDGKFG RIRLGENGGA FDSDSRWVQW PIAAISGLVA VVAAIPMLVG SLYRMVTGRM
GGGYGGRTYT SRSSFARGRG DYAVVDPDEG ELLGDDSDEE V
