VPS10_PYRTR
ID VPS10_PYRTR Reviewed; 1491 AA.
AC B2WDP9;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-2008, sequence version 1.
DT 25-MAY-2022, entry version 54.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10;
DE AltName: Full=Carboxypeptidase Y receptor;
DE Short=CPY receptor;
DE AltName: Full=Sortilin vps10;
DE AltName: Full=Vacuolar carboxypeptidase sorting receptor vps10;
DE Flags: Precursor;
GN Name=vps10; ORFNames=PTRG_08108;
OS Pyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus)
OS (Drechslera tritici-repentis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae;
OC Pyrenophora.
OX NCBI_TaxID=426418;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pt-1C-BFP;
RX PubMed=23316438; DOI=10.1534/g3.112.004044;
RA Manning V.A., Pandelova I., Dhillon B., Wilhelm L.J., Goodwin S.B.,
RA Berlin A.M., Figueroa M., Freitag M., Hane J.K., Henrissat B., Holman W.H.,
RA Kodira C.D., Martin J., Oliver R.P., Robbertse B., Schackwitz W.,
RA Schwartz D.C., Spatafora J.W., Turgeon B.G., Yandava C., Young S., Zhou S.,
RA Zeng Q., Grigoriev I.V., Ma L.-J., Ciuffetti L.M.;
RT "Comparative genomics of a plant-pathogenic fungus, Pyrenophora tritici-
RT repentis, reveals transduplication and the impact of repeat elements on
RT pathogenicity and population divergence.";
RL G3 (Bethesda) 3:41-63(2013).
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Prevacuolar
CC compartment membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250}. Note=Cycles between the Golgi apparatus and the
CC prevacuolar compartment. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC {ECO:0000305}.
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DR EMBL; DS231622; EDU51027.1; -; Genomic_DNA.
DR RefSeq; XP_001938440.1; XM_001938405.1.
DR AlphaFoldDB; B2WDP9; -.
DR SMR; B2WDP9; -.
DR STRING; 45151.EDU51027; -.
DR PRIDE; B2WDP9; -.
DR EnsemblFungi; EDU51027; EDU51027; PTRG_08108.
DR GeneID; 6346387; -.
DR eggNOG; KOG3511; Eukaryota.
DR HOGENOM; CLU_000700_0_0_1; -.
DR InParanoid; B2WDP9; -.
DR OMA; ATMSEFI; -.
DR OrthoDB; 1046610at2759; -.
DR Proteomes; UP000001471; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
PE 3: Inferred from homology;
KW Glycoprotein; Golgi apparatus; Membrane; Protein transport; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..1491
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /id="PRO_0000407533"
FT TOPO_DOM 22..1354
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 1355..1375
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1376..1405
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 1406..1426
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1427..1491
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT REPEAT 97..107
FT /note="BNR 1"
FT REPEAT 364..374
FT /note="BNR 2"
FT REPEAT 426..436
FT /note="BNR 3"
FT REPEAT 719..730
FT /note="BNR 4"
FT REPEAT 1102..1112
FT /note="BNR 5"
FT REPEAT 1143..1153
FT /note="BNR 6"
FT REGION 640..667
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1018..1047
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1464..1491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 644..667
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1477..1491
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 285
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 309
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 970
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1265
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1491 AA; 167576 MW; 9A6051365327E7C7 CRC64;
MKHLKGLLLP ALLALASSAA AKDPLVETTP FKNELVNLMY FDDSGVALVQ ELDNGKIFRS
HDAGKGWKEI KDVQGLGIIK SPYDNKVALI LGEKKHWITY DQGENWDSFE TKLPPSPQGP
VGWHAQDNKK ILLNEIENCF TAPCLGKTYY TTDGFKTDPK TLVDDRRMCQ WAKASERFLQ
GVDKHDDRIL CITRGKYSDR SKDFRLLMSD NFFKETEEPV MSSGRTVQGM ANMAAVKGYI
VAAAKAEHSS ELALYVTQDT DSWHHARFGD HKIEEDAYTI LESTNYSIQV DVMTSKYVTM
GNLYTSNSNG TYFTKNVEHT NRNDAGYVDF EKIANIQGVV LVNTVDNYKE VEKSGQSKKL
KSRISFDDGR SFEKLTVKGK DGELHLHSVT NLHNSGRVFS SPAPGIVMGV GNTGDYLGKY
TDGDLYVSDD AGLTWELALE EAHKYEFGDQ GSVLVAVFDE GDTDEIRYSF KHGRKDTWQK
IKLDYKIRAR ELTTLPDSTS LKFMIYGSRK KDGGGREHVI VHLDFSDMLK KCGDSDFDDE
WSVRKDADGD PSCVMGHKQL FRRRKWDAEC SVGELFKDPV PKFKPCDCDK FRDYECDFNF
TPTGEGKDKK CEPSESFSLP KGACEGDAKS YKGSSGWRKI PGNQCKGETE RDKQVERECK
DAERPRPKTD KITSEITKFK GSNFMEQYYL ERNTQSDGTD NDRGKDETVV MLTDERTAYI
THDHGKKWKK AVDDEIVRIY PHQYENNNVY FLTASKKVYY SKDRGLHDSI NSFEAPVMPN
TEMLPIMQFH PKQKDWIIWL GGKNCEKLGN KDCHTVAYVS QKNGEDSSWE SLVPYVKKCA
FVWREAGRSV KEEQVFCEQH TNEEKNAPLE LISSDDWFKK KDVKFKSVVE FATMSEFIIV
ATKAEDNTLH LDASLDAHTF AEAKFPPKFF DIHQTAYTVL DSSTHAVFLH VTVNPQRDQE
YGSIIKSNSN GTSYVMSLAA VNRNTEGYVD FEKMQGLEGV AVANVIVNVD EVNKGAKKKK
QSRITHNDGA DWEPLQAPEK DSDDKPYDCD IADKKKCGLH IHGYTERADP REMYSSPTAV
GLMLAVGNVG PELTTFGEAN TFMTTDAGIT WKEVKKGTYA WEFGDQGSVI VIVRRGEDTD
HVYYSVDSGA KWDLYQFADH KMRVDAITTV PSDTSLNFLL WGKDSRELFA VNLDFSGLPE
FQKECKLDEN DPTKGDYDLW SPQHPLQQDE PECLFGHVAQ YHRKKRDVKC RNGQRIDQMH
DIARNCSCTR RDFECAYNYE RDSSGDCVLV PGLSLPDPAK VCSNKNVKEY YSNTRFRKIP
LSTCQGGTEY DKTGDVHPCP GFEEDFKKNH GVGGFTLFLA IVLPFAAAAG VGYWVWRNWD
GKFGRIRLGE PGGGSAFDSD APWVRWPIAA VSGLVAVGAA LPLVVGSVWR WVVGRMGGRG
GGGGGYSGLG GSGFGRAYTS RSSFARGRGE YSVVDPDEGE LLGDEESDED V
