VPS10_PYRTT
ID VPS10_PYRTT Reviewed; 1490 AA.
AC E3RE00;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 1.
DT 25-MAY-2022, entry version 37.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10;
DE AltName: Full=Carboxypeptidase Y receptor;
DE Short=CPY receptor;
DE AltName: Full=Sortilin vps10;
DE AltName: Full=Vacuolar carboxypeptidase sorting receptor vps10;
DE Flags: Precursor;
GN Name=vps10; ORFNames=PTT_03507;
OS Pyrenophora teres f. teres (strain 0-1) (Barley net blotch fungus)
OS (Drechslera teres f. teres).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae;
OC Pyrenophora.
OX NCBI_TaxID=861557;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0-1;
RX PubMed=21067574; DOI=10.1186/gb-2010-11-11-r109;
RA Ellwood S.R., Liu Z., Syme R.A., Lai Z., Hane J.K., Keiper F., Moffat C.S.,
RA Oliver R.P., Friesen T.L.;
RT "A first genome assembly of the barley fungal pathogen Pyrenophora teres f.
RT teres.";
RL Genome Biol. 11:R109.1-R109.14(2010).
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Prevacuolar
CC compartment membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250}. Note=Cycles between the Golgi apparatus and the
CC prevacuolar compartment. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC {ECO:0000305}.
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DR EMBL; GL532319; EFQ96053.1; -; Genomic_DNA.
DR RefSeq; XP_003295855.1; XM_003295807.1.
DR AlphaFoldDB; E3RE00; -.
DR SMR; E3RE00; -.
DR STRING; 861557.E3RE00; -.
DR EnsemblFungi; EFQ96053; EFQ96053; PTT_03507.
DR KEGG; pte:PTT_03507; -.
DR eggNOG; KOG3511; Eukaryota.
DR HOGENOM; CLU_000700_0_0_1; -.
DR OrthoDB; 1046610at2759; -.
DR Proteomes; UP000001067; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
PE 3: Inferred from homology;
KW Glycoprotein; Golgi apparatus; Membrane; Protein transport; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..1490
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /id="PRO_0000407534"
FT TOPO_DOM 22..1354
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 1355..1375
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1376..1405
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 1406..1426
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1427..1490
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT REPEAT 97..107
FT /note="BNR 1"
FT REPEAT 364..374
FT /note="BNR 2"
FT REPEAT 426..436
FT /note="BNR 3"
FT REPEAT 719..730
FT /note="BNR 4"
FT REPEAT 1102..1112
FT /note="BNR 5"
FT REPEAT 1143..1153
FT /note="BNR 6"
FT REGION 1016..1048
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1465..1490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1476..1490
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 285
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 309
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 970
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1265
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1490 AA; 167500 MW; E1B092E8476B9AD9 CRC64;
MKHLKGLLLP ALLALASSAA AKDPLVETTP FKNELVNLMY FDDSGVALVQ ELDNGKIFRS
HDAGKGWKEI KNVKGLGIMK SPYDNKVALI LGEKKHWITF DQGENWDSFE TELPPSPQSP
VGWHAQDNKK ILLNEIENCF TAPCLGRTYY TTDGFKTDPK VLVDNRRMCQ WAKASERFLQ
GMDKHDDRIL CITRGKYSDR SKDFRLLMSD NFFKETEEPV MSSGRTVQGM ANMAAVKGYI
VAAAKAEHSS ELALYVTQDT DSWHHALFGD HKIEEDAYTI LESTNYSIQV DVMTSKYVTM
GNLYTSNSNG TYFTKNVEHT NRNEAGYVDF EKIANIQGVV LVNTVDNYKE VEKSGQSKKL
KSRISFDDGR SFEKLTVKGK DGELHLHSVT NLHNSGRVFS SPAPGIVMGV GNTGEFLGKY
TDGDLYVSDD AGLTWELALE EAHKYEFGDQ GSVLVAVFDE GDTDEIRYSF KHGRKDSWQK
IKLDYKIRAR ELTTLPDSTS LKFIVYASRK KDGGGREHVI VHLDFSDILK KCGDSDFDDE
WSVRKDADGD PSCVMGHKQL FRRRKWDAEC SIGELFKDPV PKFKPCDCDK FRDYECDFNF
TPAGEGKEKK CEPGESFSLP KGACDGDAKS YKGSSGWRKI PGNQCKGETE RDKQVERECK
DAERPRPKTD KITSEITKFK GSNFMEQYYL ERNTQSDGKD NERDKDETVV MLTDERTAYI
THDHGKKWKK AVDDEIVRIY PHQYETNNVY FLTASKKVYY SKDRGLHDSI NSFEAPVMPN
TDMLPIMQFH PKQKDWIIWL GGKNCEKVGN KDCHTVAYVS QKNGEDSSWE SLVPFVKKCA
FVWREAGRSV KEEQVFCEQH TNEEKNAPLE LISSDDWFKK KDVKFKSVVE FATMSEFIIV
ATKAEDNTLR LDASLDAHTF AEAKFPPKFF DIHQTAYTVL DSSTHAVFLH VTVNPQRDQE
YGSIIKSNSN GTSYVMSLAA VNRNSEGYVD FEKMQGLEGV AVANVVVNVD EVNKGSKKKK
QSRITHNDGA DWEPLQAPEK DSDDKPYDCD VANREKCGLH IHGYTERADP REMYSSPTAV
GLMLAVGNVG PELSTFGEAN TFMTTDAGIT WKEIKKGTYA WEFGDQGSVI VIVRRGEDTD
HVYYSTDSGA KWDLYQFADH KMRVEAITTV PSDTSLNFLL WGKDSKELFA VNLDFSGLPE
FQKECKLDEH DPTKGDYDLW SPQHPLQQDE PECLFGHVAQ YHRKKRDVKC RNGQRIDQMH
DIARNCSCTR RDYECAYNYE RDSSGDCVLV PGLSLPDPSK VCSNKNVKEY YANTRFRKIP
LSTCQGGTEY DKTGDVHPCP GFEEDFQKNH GVGGFTLFLA IVLPFAAAGG VGYWVWRNWD
GKFGRIRLGE PGGGSAFDSD APWVRWPIAA VSGLVAVIAA LPLVVGSVWR WVAGRMGGGG
GAGGYAGLGG SGYGRAYTSR SSFARGRGEY SVVDPDEGEL LGDEESDEDV
