VPS10_SCHJY
ID VPS10_SCHJY Reviewed; 1456 AA.
AC B6JY29;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 1.
DT 25-MAY-2022, entry version 48.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10;
DE AltName: Full=Carboxypeptidase Y receptor;
DE Short=CPY receptor;
DE AltName: Full=Sortilin vps10;
DE AltName: Full=Vacuolar carboxypeptidase sorting receptor vps10;
DE Flags: Precursor;
GN Name=vps10; ORFNames=SJAG_01488;
OS Schizosaccharomyces japonicus (strain yFS275 / FY16936) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=402676;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yFS275 / FY16936;
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
CC Prevacuolar compartment membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}. Note=Cycles between the Golgi apparatus
CC and the prevacuolar compartment. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC {ECO:0000305}.
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DR EMBL; KE651168; EEB06447.1; -; Genomic_DNA.
DR RefSeq; XP_002172740.1; XM_002172704.2.
DR AlphaFoldDB; B6JY29; -.
DR SMR; B6JY29; -.
DR STRING; 4897.EEB06447; -.
DR EnsemblFungi; EEB06447; EEB06447; SJAG_01488.
DR GeneID; 7051446; -.
DR VEuPathDB; FungiDB:SJAG_01488; -.
DR eggNOG; KOG3511; Eukaryota.
DR HOGENOM; CLU_000700_0_0_1; -.
DR OMA; ATMSEFI; -.
DR OrthoDB; 1046610at2759; -.
DR Proteomes; UP000001744; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005770; C:late endosome; IEA:EnsemblFungi.
DR GO; GO:0005802; C:trans-Golgi network; IEA:EnsemblFungi.
DR GO; GO:0006895; P:Golgi to endosome transport; IEA:EnsemblFungi.
DR GO; GO:0006896; P:Golgi to vacuole transport; IEA:EnsemblFungi.
DR GO; GO:0006623; P:protein targeting to vacuole; IEA:EnsemblFungi.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
PE 3: Inferred from homology;
KW Glycoprotein; Golgi apparatus; Membrane; Protein transport; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..1456
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /id="PRO_0000407535"
FT TOPO_DOM 23..1348
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 1349..1369
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1370..1456
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 62..71
FT /note="BNR 1"
FT REPEAT 106..114
FT /note="BNR 2"
FT REPEAT 448..458
FT /note="BNR 3"
FT REPEAT 489..499
FT /note="BNR 4"
FT REPEAT 823..834
FT /note="BNR 5"
FT REPEAT 1100..1110
FT /note="BNR 6"
FT REPEAT 1141..1150
FT /note="BNR 7"
FT CARBOHYD 44
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 330
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 349
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 974
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1135
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1456 AA; 163939 MW; 1FEFBDDA1BC729E0 CRC64;
MLHHCVLHII CALFFFLPLG GADSNYAISK LGTASKSQKS LIVNFSKSRN ILLLDATGTL
LLSQDDGTSW QDAVSNSDPA VVEQLYQHPF EDDIVYAITK ESDILVSEDA GLTWFTVTMP
PKTVIEAQPF EFNARQSQSV ILNAARCESG SIWTGVTCYP FTYYTYDNFR NLDSVHDSIV
SCTFAVGTVE FAGQDEDQML CLIRENDVDL QAPFNQQLIS VSKGFESIDY VVFDPYYGSL
GTESVVAVGQ YLVAAVVDVN SKKLKLHYST DGQIWVPITF INAPSIGSLT VTRSTSLTLG
VDVESTNLKN PVGEFYTISP SDAYAVRRLN DTNRDTRGYV DVIELDYLNN TILANTVANT
EDLYKRASRQ KELVTKISHD GGFSWTQLER PVDLECEGDD AEDCHLHLHL GITETKFGSL
SPDRLPGVIM ALGSVGTHLQ PLSDSDLFIS EDAGRSWYLS LQGPHYYSSS AYGSVFVAVK
ANENSKLIYY SLDFGREWES LEVEASFRAL EIIPPKSLDS LTFLIRAKVK KEESFIAIDF
SSILSRECTF DEKKVANGDF ELWYPFVMDD TPQCLMGRIE YYLRKKRAVS CVVRNEVPVH
SFVEQICTCE SKDYECSTYF EPSDHFTCEV NPESLDPLCR VDPDATLQLK PYRILLGNSC
VPKKKEEKEK SISMKCPKLD HRKDIHMYHH KIQDTISNIV YMEGTGEPDS TTELLLTSSQ
KVLFSYDFGE EWLEFDEKKN PSFYGIYPHA FLKDTAFLLT KDRKIYFTNN KGRSFYRLDA
PSPPNVVGYP VFNFHSLHPN WVMYMGSENC DDSFYEDCRS VVYLSFDSGA SWQKLPDELE
YCSWVLGERL LVEDKLLFCN RRRAAADSIG YDLVASTDFF ETEASSIREN VLGFLLADEY
VVIAALTDDE TSLSMHVSVN GRNFSPCIFP QNIQVHSQQA YTILSSKTRA LFIHVTLSSR
KGAEWGSVLK SNSNGTYFVN VLDKVNRNEL GYVDFEKVEG LESIALANVV LNSDEAFNGE
EKRLGTLITF NDGIDWERLY LIDAKKHYPH CDSKCSLHFH GFTERSVFSD PTSSSAATGI
IFGIGSYSYY LEPYETSQTF ISRDGGVHWE LIFDSPHQWA FVDSGSLLVA VPSTNKTNIL
YYSEDEGRSW IAYQFAEDTY LIEDLSTAPS GNSQRILVLA KGKKSSETIS FTVDFSHLRS
RVCVFDFNDQ RDFASWTPAG RDGKPMCLFG HKTAFYRRKP GRDCFIGNTP YVSDTIISNC
QCTRMDYECN YNYERIAGGT CRLVSGAEPP LQQEEQCAAE GAIEWMEPTA YKRIPLTTCE
GGLVLDESTT HPCPGKEDDY HKIHPGTPVW LIIMLVLLSV FLSTIVGAWV YTKAQSYLVG
AIRLGEDPAD ETVFAKLMTR IESVVTAVPI FFSAAYHLVR SVFVRQDRSM SLDDYDNFEG
MEDAAFLEVD DIETSE
