VPS10_SORMK
ID VPS10_SORMK Reviewed; 1525 AA.
AC D1Z9Q3; F7W1I5;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 25-JAN-2012, sequence version 2.
DT 25-MAY-2022, entry version 46.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10;
DE AltName: Full=Carboxypeptidase Y receptor;
DE Short=CPY receptor;
DE AltName: Full=Sortilin vps10;
DE AltName: Full=Vacuolar carboxypeptidase sorting receptor vps10;
DE Flags: Precursor;
GN Name=vps10; ORFNames=SMAC_04327;
OS Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Sordaria.
OX NCBI_TaxID=771870;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-333 / DSM 997 / K(L3346) / K-hell;
RX PubMed=20386741; DOI=10.1371/journal.pgen.1000891;
RA Nowrousian M., Stajich J.E., Chu M., Engh I., Espagne E., Halliday K.,
RA Kamerewerd J., Kempken F., Knab B., Kuo H.-C., Osiewacz H.D., Poeggeler S.,
RA Read N.D., Seiler S., Smith K.M., Zickler D., Kueck U., Freitag M.;
RT "De novo assembly of a 40 Mb eukaryotic genome from short sequence reads:
RT Sordaria macrospora, a model organism for fungal morphogenesis.";
RL PLoS Genet. 6:E1000891-E1000891(2010).
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Prevacuolar
CC compartment membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250}. Note=Cycles between the Golgi apparatus and the
CC prevacuolar compartment. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CABT02000019; CCC04960.1; -; Genomic_DNA.
DR AlphaFoldDB; D1Z9Q3; -.
DR SMR; D1Z9Q3; -.
DR STRING; 771870.D1Z9Q3; -.
DR PRIDE; D1Z9Q3; -.
DR EnsemblFungi; CCC04960; CCC04960; SMAC_04327.
DR eggNOG; KOG3511; Eukaryota.
DR HOGENOM; CLU_000700_0_0_1; -.
DR InParanoid; D1Z9Q3; -.
DR OMA; ATMSEFI; -.
DR OrthoDB; 1046610at2759; -.
DR Proteomes; UP000001881; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
PE 3: Inferred from homology;
KW Glycoprotein; Golgi apparatus; Membrane; Protein transport; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..1525
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /id="PRO_0000407536"
FT TOPO_DOM 25..1384
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 1385..1405
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1406..1439
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 1440..1460
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1461..1525
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT REPEAT 62..72
FT /note="BNR 1"
FT REPEAT 105..116
FT /note="BNR 2"
FT REPEAT 449..460
FT /note="BNR 3"
FT REPEAT 493..502
FT /note="BNR 4"
FT REPEAT 748..759
FT /note="BNR 5"
FT REPEAT 1135..1145
FT /note="BNR 6"
FT REPEAT 1178..1188
FT /note="BNR 7"
FT CARBOHYD 308
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 734
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1005
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1294
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1525 AA; 171638 MW; E65B5C3B4B09980E CRC64;
MRVRGALQAA ALLASALWAS PLLAKDHPDF KTTKLDTQPN NLNYFQGSDT ILFHDPHKAN
LWRSDDAGAT WSVVKDIPDG KVARLYMHDF DPKRAFAITD GRKHYRTTDQ GKTWKKFEIN
AEWDTERYDI LHFHATDPDR IIFNGLNCLG FLCEEVSLYT IDGFDTPAKP LRPDTLGCWW
AKSNALFTTG DSDLDKDRIL CIIMGVDSIF TEDRRLVISD DFFKADKEGN IQEFEPNLAG
DKPVRGVVNV AAVKRYFMVA TTSANTDEMA LFISTDTKKW QRAMFPNAHD DHDHKIVQEA
YTVLESTNYS IQLNVMTGSK SQPMGIMFTS NYDGTYFTEN LEYTNLNMYG HVDFEKIAGI
QGIFLVNKVD NGKDVDEKPS TKKKLVSEIT FDDGRTFEKV TADGKRIHLH SVTELNNVGR
VFSSPAPGLV MANGNTGDYL EDYWDANLYV SDDAGKTWKK ALKGPHKYEF GDQGSILVAV
RDSKEEDVSE ISYSLDHGEN WVEEKLPDDL KIQPWILTTT PDSTTLQFVL IGKAKGAWQV
IHIDFEALHE ATCKDSDMEE WHARVDKDGE STCIMGHTQT FPRRKKDAKC FLKKEFKLAE
VETKDCDCTD QDYECDYSFE RNDKGNCVSK GPIPIPEGAC KDGDKNGKFM GTSGYRKIPG
NTCKDTKDTK DKYKDVERSC GDGIGAPPEE ATGELQQVDT KGKFGHWTQW EKHYLERGES
SSDSSETIIM RGKNRTVDDS GPKAGPIWRT TDHGKTWEKI DFFKDEEVIS IVPHPTVKDW
VFFLTEGKKL IYTPDRGKRF RTFDVPQPAD LEAAANGIFP LIFHPDKPNW LIWLGKKCES
KNDCYRVAYG TKDGERWETL ARDVYRCEFT GAEAYGRKYA NRALEQILCL KHEKEGASDS
ALQLVSSNDW FNKDEKVRLK DAKEFATMAE FIVVATEDTE KKTLRAHASL DGGLYSEAKF
PFGFEVPHQH AYTVLDSSTH AVNLFVATKM EGDKSLGTIL KSNSNGTSYV VSVKNVNCDQ
YFYVDFEKMV GLEGVALVNV VANPDAKSSA PQKLQTKITH NDGAQWAYLP TPSKDEFGRF
PCSSSGTEKC ALHIQGYTQR RDRGKTYSSE GAVGVMFGWG NVGDSLGPLK DADTFMTTDA
GITWKRVKKG RWNWALGDQG SIIVMVPIRG QKTDTLEYSL DQGATWKKHT FSKEKVDIWD
LTTTRSGNSQ NFLIWGENSD GLFTTKIDFT KFTDHVCKYD PENLGKSDYQ IFSPKHPLQP
DGCLFGHVSQ YLRKKPGLKC FNDFRLDPLY SKQNCTCTRS DFECDFNYEL DNHGQCALVK
GLKPQDPKLW CKEHPDEIEY YEPTGYRRIP LTTCQGGADF EKQAAVHPCP GHEDDFERKH
RISGIAIFFA VVLPVAAASA IGWWVYRNWD GKFGQIRLGE QGASTMEFFD ADRPWVKYPV
IALSAVVALA GAMPLVLAAI WRTAKNTAQR FGVGGGGRGG WSRLDGGGAS RTFRTRDSFA
RGRGDYTIVD EDEGELLGEE SDEEV
