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VPS10_TALMQ
ID   VPS10_TALMQ             Reviewed;        1504 AA.
AC   B6QMS8;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Vacuolar protein sorting/targeting protein 10;
DE   AltName: Full=Carboxypeptidase Y receptor;
DE            Short=CPY receptor;
DE   AltName: Full=Sortilin vps10;
DE   AltName: Full=Vacuolar carboxypeptidase sorting receptor vps10;
DE   Flags: Precursor;
GN   Name=vps10; ORFNames=PMAA_060750;
OS   Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)
OS   (Penicillium marneffei).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC   Talaromyces sect. Talaromyces.
OX   NCBI_TaxID=441960;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 18224 / CBS 334.59 / QM 7333;
RX   PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA   Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT   "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT   (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT   (ATCC10500).";
RL   Genome Announc. 3:E0155914-E0155914(2015).
CC   -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC       required for the intracellular sorting and delivery of soluble vacuolar
CC       proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC       multiple rounds of sorting by cycling between the late Golgi and a
CC       prevacuolar endosome-like compartment (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC       {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Prevacuolar
CC       compartment membrane {ECO:0000250}; Multi-pass membrane protein
CC       {ECO:0000250}. Note=Cycles between the Golgi apparatus and the
CC       prevacuolar compartment. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC       {ECO:0000305}.
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DR   EMBL; DS995903; EEA22297.1; -; Genomic_DNA.
DR   RefSeq; XP_002150906.1; XM_002150870.1.
DR   AlphaFoldDB; B6QMS8; -.
DR   SMR; B6QMS8; -.
DR   STRING; 441960.B6QMS8; -.
DR   EnsemblFungi; EEA22297; EEA22297; PMAA_060750.
DR   GeneID; 7028387; -.
DR   KEGG; tmf:PMAA_060750; -.
DR   VEuPathDB; FungiDB:PMAA_060750; -.
DR   HOGENOM; CLU_000700_0_0_1; -.
DR   OrthoDB; 1046610at2759; -.
DR   PhylomeDB; B6QMS8; -.
DR   Proteomes; UP000001294; Unassembled WGS sequence.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR031777; Sortilin_C.
DR   InterPro; IPR031778; Sortilin_N.
DR   InterPro; IPR006581; VPS10.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   Pfam; PF15902; Sortilin-Vps10; 2.
DR   Pfam; PF15901; Sortilin_C; 2.
DR   SMART; SM00602; VPS10; 2.
PE   3: Inferred from homology;
KW   Glycoprotein; Golgi apparatus; Membrane; Protein transport; Receptor;
KW   Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix;
KW   Transport.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000255"
FT   CHAIN           32..1504
FT                   /note="Vacuolar protein sorting/targeting protein 10"
FT                   /id="PRO_0000407530"
FT   TOPO_DOM        32..1370
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1371..1391
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        1392..1423
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1424..1444
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        1445..1504
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   REPEAT          70..80
FT                   /note="BNR 1"
FT   REPEAT          118..128
FT                   /note="BNR 2"
FT   REPEAT          394..403
FT                   /note="BNR 3"
FT   REPEAT          455..465
FT                   /note="BNR 4"
FT   REPEAT          739..749
FT                   /note="BNR 5"
FT   REPEAT          1120..1130
FT                   /note="BNR 6"
FT   REPEAT          1161..1171
FT                   /note="BNR 7"
FT   REGION          1485..1504
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        313
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        338
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        986
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        998
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1281
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1504 AA;  168450 MW;  56DE5CF18E0AB491 CRC64;
     MTRQWLHLTT SPLLLLLLLI TISSLTGGAV AKSDGPKIAL KEVEVVPEQP FYFENTDTVL
     FLSAATGEVY RSFDGGLEWH VIGKGEGEEG LTNDAVVILP HKYDNKKAYI LGRHGAHWVT
     TDQGRTWRRF EVPAAPSMLL YERLRFHGED SRKVIFMGER CSLVACLETA FYTLDDFETV
     APLRDTARGC FWAVGTPAFA ESTTEYAKEI GDRVLCIVHG LKNPFAAAYR LVYSDSFFKD
     NEDGIEANLN AGRPVAGIIN AAARTKYIMV AAKSQGTDEL AMFVTDDAIT WHRAEFGNHK
     IEEGAYTVLG GTNYSIQVDV KNTDRSESMG VLFTSNSNGT YFTRNIEHTN RNMEGYVDFE
     DIIGVQGIVL VNVVDNWEEV EKKFDADKKV ISKISFDDGR TFQPLKANDK DLHVHSVTDF
     QNIGRVFSSP APGIVLGVGN TGSHLKSYTK DGNLYVSDDA GVTWRLALEK PHKYEIGNKG
     AVIVAIKDDG DPTGKIQFSI NHGKDWDTAE LDHKIIPFYL TTTPDSTSLK FLLVGFSEES
     RKWSIFAIDF EGLHERECKE SDFEEWPARL DEKGEPDCLM GHKQYYRRRK SDADCFITET
     MFKTPTPEFK ACKCTAEDFE CDYNFVRSED RTKCVPATPL KAPEGACKSE DDTFKGPSGW
     RLIPGNACIR DGGEELDKEI DRPCKDVLKA PPGDAKAISS TVNYIEAEMF KSFYYLERAG
     SSRGEDETIV MLTSNGKLYV THNHGKTWTH ELTDVKFEEI VRNPYLNDRA FFLTNGKKQF
     YTINRAETFE SFTAPAEKNP DPGMTLGFHE IYKDWMIWTG PSDCSHGNCP KDSYFTKHRG
     DGWEILLRAV INCEFMAQES RGEESNNLIF CNQHEAEEVD GQRMLVTSND FFDTSKTPLP
     RIIAFAKASE FIIIAKPDPE KEHAMKFDVS VDGVTFADAE YSVNLEVSME LGYTLLQSTT
     HSVFMHVTLN DQRDHQYGLL IKSNSNGTSY VLSLSDVNRS NDGYVDFEKL QGLEGVVIAN
     VVSNTKDVEK GSEKKLRTMI THNDGAQWTL IPPPVKDSEG KGYNCGSDGK PTDKCALHLH
     GYTERRDSRN TFASASAIGL SFGVGNVGES LVSKADASTF FSRDGGISWK EVKKGSHFWE
     YGDQGSVLVL VAEGKPTREV FFSTDEGDTW EVYQFSEKEV TVLDFSTVPS DTSKNFLIWA
     REAGSDKLVT INLDFSGLRD RTCHLDEDTG ESEDYYIWEP KHPLQEGNCL FGHVEQYHRK
     NPKSHCWNDW SEAHVHSISH NCSCTFQDYE CDYNYERQTD GSCALVPGLP KPNAIEYCKE
     NPDAVEYWEP TGYRRIPITT CTGGKNLDQW ISHPCPGHQE EYERKHGVSG AVIFFAIIIP
     IAIAVAAGYW VYTHWDGKFG QIRLGEGGGQ SFITSRGDSP FITIPVVIIA GTVAAVKVLP
     LLFMSLWRSA SGYVHLPGSR GPRPYATRGA FASRRGDYTN VVDDEDELLG DDEFEDEEGD
     EERS
 
 
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