ID   VPS10_TALSN             Reviewed;        1502 AA.
AC   B8MG72;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Vacuolar protein sorting/targeting protein 10;
DE   AltName: Full=Carboxypeptidase Y receptor;
DE            Short=CPY receptor;
DE   AltName: Full=Sortilin vps10;
DE   AltName: Full=Vacuolar carboxypeptidase sorting receptor vps10;
DE   Flags: Precursor;
GN   Name=vps10; ORFNames=TSTA_010560;
OS   Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL
OS   1006) (Penicillium stipitatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC   Talaromyces sect. Talaromyces.
OX   NCBI_TaxID=441959;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006;
RX   PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA   Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT   "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT   (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT   (ATCC10500).";
RL   Genome Announc. 3:E0155914-E0155914(2015).
CC   -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC       required for the intracellular sorting and delivery of soluble vacuolar
CC       proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC       multiple rounds of sorting by cycling between the late Golgi and a
CC       prevacuolar endosome-like compartment (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC       {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Prevacuolar
CC       compartment membrane {ECO:0000250}; Multi-pass membrane protein
CC       {ECO:0000250}. Note=Cycles between the Golgi apparatus and the
CC       prevacuolar compartment. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC       {ECO:0000305}.
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DR   EMBL; EQ962656; EED15939.1; -; Genomic_DNA.
DR   RefSeq; XP_002483173.1; XM_002483128.1.
DR   AlphaFoldDB; B8MG72; -.
DR   SMR; B8MG72; -.
DR   STRING; 441959.B8MG72; -.
DR   EnsemblFungi; EED15939; EED15939; TSTA_010560.
DR   GeneID; 8109829; -.
DR   VEuPathDB; FungiDB:TSTA_010560; -.
DR   eggNOG; KOG3511; Eukaryota.
DR   HOGENOM; CLU_000700_0_0_1; -.
DR   InParanoid; B8MG72; -.
DR   OMA; ATMSEFI; -.
DR   OrthoDB; 1046610at2759; -.
DR   PhylomeDB; B8MG72; -.
DR   Proteomes; UP000001745; Unassembled WGS sequence.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR031777; Sortilin_C.
DR   InterPro; IPR031778; Sortilin_N.
DR   InterPro; IPR006581; VPS10.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   Pfam; PF15902; Sortilin-Vps10; 2.
DR   Pfam; PF15901; Sortilin_C; 2.
DR   SMART; SM00602; VPS10; 2.
PE   3: Inferred from homology;
KW   Glycoprotein; Golgi apparatus; Membrane; Protein transport; Receptor;
KW   Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix;
KW   Transport.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..1502
FT                   /note="Vacuolar protein sorting/targeting protein 10"
FT                   /id="PRO_0000407537"
FT   TOPO_DOM        30..1369
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1370..1390
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        1391..1422
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1423..1443
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        1444..1502
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   REPEAT          68..78
FT                   /note="BNR 1"
FT   REPEAT          120..130
FT                   /note="BNR 2"
FT   REPEAT          395..404
FT                   /note="BNR 3"
FT   REPEAT          456..466
FT                   /note="BNR 4"
FT   REPEAT          498..508
FT                   /note="BNR 5"
FT   REPEAT          740..750
FT                   /note="BNR 6"
FT   REPEAT          1119..1129
FT                   /note="BNR 7"
FT   REPEAT          1160..1171
FT                   /note="BNR 8"
FT   CARBOHYD        314
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        339
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        985
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1280
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1502 AA;  168336 MW;  76611BEB0DF5A979 CRC64;
     MIRQCLHLTT SPLLLLLLIA LSSIGTVVAK SDGPKIASIQ LETEPSMPFY FENSDTVLFL
     RLDTGEVYQS FDGGVEWKVL GKDHETEGET AGLANGAVMI QAHPYDNQKA YILGRHGVHW
     VTTDQGKTWR EFEVPAAPSM FNEPLRFHGE DSGKVIFQGE RCSAFACVET SYYTRNNFET
     VKPMRDTARG CMWAVATPGF ADSTTEHAEE IRDRVLCIVH GLKNPFASAY RLVYSDSFFE
     DDQDGIEAKL NEGRPVAGII NAAARTKYIV AAAKSQGTDE LAMFVTDDAI TWHRAEFGNH
     KIEESAYTVL EGTNYSIEVD VMNTDRSTNM GVLFTSNSNG TYFTRNIEHT NRDMSGLVDF
     EKIAGVQGIV LVNVVDNWEE IENDPKADRK VISKISFDDG RTFQSLKVKD KDLHLHSVTA
     FENIGRVFSS PAPGIVMGVG NTGTHLKSYT KDGDLYVSDD AGVTWRLALE KPHKYEIGNK
     GAIIMAIKDN DKPTKKIQYS INHGKDWETA ELDREIIPYF LTTTPDSTSL KFMLVGYVED
     PADWYIYAID FEGLHERECK DSDFENWPAR LDENGEPDCL MGHKQFYRRR KSDANCFITE
     TMFKTPKPEF KSCKCTAEDF ECDYNFVRSE DRKECVPATI LKAPEGTCKN DDDTFKGPSG
     WRLIPGNVCT RDGAVELDKE IDRPCKDALK TPSGDSKAVS STANYIETEM FGEFFYLERA
     GSSRGEDETI IMRTTDGKLY VTHDHGKSWT HELKDVKIQQ IAPHRYLNDR AFFLTSGKKQ
     YYTINRAESF DAFSAPAEVN PSGLTLGYHE EFKDWMIWTG PGECSHGECP KVSFISKHRG
     DDWEILLRAV EKCEFMARED RKDSGSLIFC DQHEGEKVDG QRMLVTSNDF FATSTTPLTN
     IIDFATMAEF IIIATRNPEK ENSLKVDASV NGVEFADAEF PYNLEVPVQL AYTVLDSSTH
     SVFLHVTANN KMDQSYGSII KSNSNGTSYV LSLNDVNRNN GGYVDFEKLP GLEGVALANV
     VSNTKNVEKG SEKKLTSMIT HNDGSQWTLI PPPAKDSEGK PYSCGSDGKP TDKCSLHLHG
     YTERRDPRDS FGSASAIGLL FGVGNVGESL GSKSEASTFF SSDGGISWKE VKKGNYMWKF
     GDQGSVLVLV EELKPTRDIY FSTDEGDTWE KYQFSEKEVT VQSLSTVPSG TSKNFLIWGK
     ETGSSKLVTI NLDFSGLRDR TCNLDEDTGE SEDYYLWEPK HPLQEGNCLF GHVEQYHRKK
     PSSHCWNDWS EAHVHRISHN CTCTEEDYEC DYNYERQTDG SCALVPGLLK PNAIDYCREN
     PEAIEYWEPT GYRRIPLTTC QGGKNLDRWV SRPCPSHEEE YQRKHGPSGA VIFFAIIVPI
     TIAVAAGYWV YTRWDGKFGQ IRLGDGGAQS FVTSRGDSPF ITIPVAIIAG TVAAVKVLPL
     LVMSLWRSVT GYVRIPGRRG PRPYATRDAF AARRGDYTHV VDDEDELLGD DEFEDEEGDE
     RN