VPS10_UNCRE
ID VPS10_UNCRE Reviewed; 1483 AA.
AC C4JI06;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 07-JUL-2009, sequence version 1.
DT 25-MAY-2022, entry version 48.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10;
DE AltName: Full=Carboxypeptidase Y receptor;
DE Short=CPY receptor;
DE AltName: Full=Sortilin VPS10;
DE AltName: Full=Vacuolar carboxypeptidase sorting receptor VPS10;
DE Flags: Precursor;
GN Name=VPS10; ORFNames=UREG_01431;
OS Uncinocarpus reesii (strain UAMH 1704).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Uncinocarpus.
OX NCBI_TaxID=336963;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 1704;
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Prevacuolar
CC compartment membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250}. Note=Cycles between the Golgi apparatus and the
CC prevacuolar compartment. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC {ECO:0000305}.
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DR EMBL; CH476615; EEP76582.1; -; Genomic_DNA.
DR RefSeq; XP_002541915.1; XM_002541869.1.
DR AlphaFoldDB; C4JI06; -.
DR SMR; C4JI06; -.
DR STRING; 336963.C4JI06; -.
DR EnsemblFungi; EEP76582; EEP76582; UREG_01431.
DR GeneID; 8440685; -.
DR KEGG; ure:UREG_01431; -.
DR VEuPathDB; FungiDB:UREG_01431; -.
DR eggNOG; KOG3511; Eukaryota.
DR HOGENOM; CLU_000700_0_0_1; -.
DR InParanoid; C4JI06; -.
DR OrthoDB; 1046610at2759; -.
DR Proteomes; UP000002058; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
PE 3: Inferred from homology;
KW Glycoprotein; Golgi apparatus; Membrane; Protein transport; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..1483
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /id="PRO_0000407539"
FT TOPO_DOM 21..1356
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 1357..1377
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1378..1405
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 1406..1426
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1427..1483
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT REPEAT 58..67
FT /note="BNR 1"
FT REPEAT 103..113
FT /note="BNR 2"
FT REPEAT 375..385
FT /note="BNR 3"
FT REPEAT 436..447
FT /note="BNR 4"
FT REPEAT 478..487
FT /note="BNR 5"
FT REPEAT 718..728
FT /note="BNR 6"
FT REPEAT 817..826
FT /note="BNR 7"
FT REPEAT 1100..1110
FT /note="BNR 8"
FT REPEAT 1141..1151
FT /note="BNR 9"
FT CARBOHYD 295
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 966
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1262
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1483 AA; 166460 MW; B962C3CD3C8E10E2 CRC64;
MILRRLLLAG SLLLASLAAA KKEGPKITAT KFDHEPRHLF YFEDTDTVVF QHKYDAHIST
DAGQSWSVIK GPDDGMVGKV KSIYPHPHDR KKAYVFGQSR THWVTEDAGK SWRAFKIEQD
IPRSGNPLAF HGTDSDKLIL HTIDCSGFVC DMPALYTTDG FKSHKTLTKS QHGCNWAITT
PEFGTQADLP EKIDNRVFCI FSGLHAPMGR NKRLLYSDNF FEDDKGFEVP LNNGRPVSDV
VRLAGVKKFL VAAAKSPRTT EMTLYVTDDA TRWHQAMFDG HKLENDAYTV LESTNYSIQV
GVKTTGGFNP MSALYTSNSE GIYFTRNAEH VNSNHLGYID FEKIAGIQGI FLINTVSNWE
EIDNNHQRKK KVVSQISFDD GRTFHDIKAG DKKLHLHSVA QLHNSGRVFS SPAPGVVMGV
GNVGDHLKEY DEGDLYVSND AGITWSKALE DAHKYEFGDL GSVLVAVYDE GRTNKVSYSI
DHGKHWETAE LPHKIRARVL TTTPDSTSLK FVLIGTSKSG SGVEHSVIGI DFSNLHERKC
GKDDFERWPA RLNEKNEPDC LMGHKQFYSR RKAGSECFIG SEFKDPVPEL ERCKCTEEDF
ECDFNFVRSK DRKDCVPARA LPVPEGQCKK PDDKYTGSSG FRLIPGNDCV KDGGIELDKP
KERPCSDAAK EPVSGEIDVT KHFFSANKPA EYYYLERPVL SKDKDETIVM LTDKLEVFIT
RDHGKTWKET LEGKHVVKLW PHTYINDAMY FITGEKRVIV TKNRGDSFRE FETKLLPNRD
RLPVLAFHPD PERSDWLIWT GADNCGRGGD CHSVAHYSTD GGDEWHTLMR YVGRCEFIGK
ERSRKTDELI FCAQHENENP KNRHLRLVSS DSWFKDKTVH YNNILDFRTM AEFIIVAARS
EKDSLKVGAS IDGKTFADAE FPANFDVKVQ QAYTVLDSST HSVWLHVTVH NVEDHQYGSI
IKSNSNGTSY VLSLNNVNRN NADYVDFEKM EGLEGVALVN VVANVDEVQK GAAKQLRTMI
THNDGAEWAY IRPPAKDADG RAYSCSPGKK GTEECGLHLH SFTERPDYRD TFSSPSAVGL
MLAVGNVGDH LTLKSEGDTF ITRDGGIEWH SVKKGNYIWE YGDQGSIIVI VPEAKPTKAL
FYTLDEGKTW TEFAFSEVEM LILDISTVPS DTSRNFLLWG KEVGSGSKPG FATVNIDFSG
LKERSKECVL KEDKPEADDY YLWEPKHPLL EDNCLFGHIT RYHRKKPEAS CYNGGDFERL
HNVSTNCECT RQDYECDYNF ERQSDGSCAL VPGHQPLDPK RICTEDSKAI EYFEPTGYRR
IPLTTCEGGL KLDGFKAFPC PNKEKEFEKK HPRLHGAGLF FAIVLPIAAA GVVGYYVYTR
WDGKFGRIRL GESGSSGDWL SRDSPLIAIP IAIIAGTVAV LSALPLLAAS LWRSARGWTP
IGRSSRPYSS RGAFAARRGD YVGVVEDEDE LLGAEDFEED EEV
