VPS10_VANPO
ID VPS10_VANPO Reviewed; 1601 AA.
AC A7TT43;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 02-OCT-2007, sequence version 1.
DT 25-MAY-2022, entry version 65.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10;
DE AltName: Full=Carboxypeptidase Y receptor;
DE Short=CPY receptor;
DE AltName: Full=Sortilin VPS10;
DE AltName: Full=Vacuolar carboxypeptidase sorting receptor VPS10;
DE Flags: Precursor;
GN Name=VPS10; ORFNames=Kpol_361p4;
OS Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX NCBI_TaxID=436907;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC Y-8283 / UCD 57-17;
RX PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT species descended from a whole-genome duplication.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
CC Prevacuolar compartment membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}. Note=Cycles between the Golgi apparatus
CC and the prevacuolar compartment. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC {ECO:0000305}.
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DR EMBL; DS480541; EDO14567.1; -; Genomic_DNA.
DR RefSeq; XP_001642425.1; XM_001642375.1.
DR AlphaFoldDB; A7TT43; -.
DR SMR; A7TT43; -.
DR STRING; 436907.A7TT43; -.
DR PRIDE; A7TT43; -.
DR EnsemblFungi; EDO14567; EDO14567; Kpol_361p4.
DR GeneID; 5542578; -.
DR KEGG; vpo:Kpol_361p4; -.
DR eggNOG; KOG3511; Eukaryota.
DR HOGENOM; CLU_000700_0_0_1; -.
DR InParanoid; A7TT43; -.
DR OMA; IFMHVTT; -.
DR OrthoDB; 1046610at2759; -.
DR PhylomeDB; A7TT43; -.
DR Proteomes; UP000000267; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
PE 3: Inferred from homology;
KW Glycoprotein; Golgi apparatus; Membrane; Protein transport; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..1601
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /id="PRO_0000407541"
FT TOPO_DOM 21..1430
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 1431..1451
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1452..1601
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 58..67
FT /note="BNR 1"
FT REPEAT 100..110
FT /note="BNR 2"
FT REPEAT 439..448
FT /note="BNR 3"
FT REPEAT 510..520
FT /note="BNR 4"
FT REPEAT 556..566
FT /note="BNR 5"
FT REPEAT 796..806
FT /note="BNR 6"
FT REPEAT 838..849
FT /note="BNR 7"
FT REPEAT 893..903
FT /note="BNR 8"
FT REPEAT 1178..1188
FT /note="BNR 9"
FT REPEAT 1220..1228
FT /note="BNR 10"
FT REGION 349..369
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1558..1601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 353..369
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1571..1591
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 121
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 156
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 457
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 505
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1044
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1289
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1339
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1601 AA; 180588 MW; BB67E9D9DC56C85F CRC64;
MLLSQWLLTT CILISSYVHA ADQFKPKVVR TESTGWFNIY PFDDSKVILK NEDTFLSISD
NNGETWRPIE GINDVRWSWI DKLYPKTRAF ANSKVGNKIY MTDDQGKTWT TVKINEKEYS
NGSKSELSCN LISHPTKPEI LLAECYVCDY DEEQSNGSIT KRAVSSLFDN FLNSIMRDPT
CRNEVFISTN SGKDFTKLNI DLKEREESNL LYSTLNCQFA IASKQSKNTE TDSTIYCTRK
HFYGQKFNDK NEADKTYLVS SFVKTSNWGK TFEELPELKG YLVNYFEAFD SQLLVITQDD
AYNRHSTQKV WISKDFKTFK EAHMPTQLRF MINGLISEDS VGRLTMPILR TNPDKKDSSD
KNEDNKKMHH TDSVVSDILI SDSRGTKFTF IEWMNSNDVT YRQISSFKYL KGTLFGHTQE
YPNLGNKGPS FEMILRSKVS VDNGNTWSNL KIVDPENKSK YSCNIDIPES CSLNIMSMFG
TPDFITPGIM MVNGAVSDGH HASWNETKTF ISRDGGVSWK LAFEFQTATA FGDHGNVIVA
VPYDPESDDD PQSEFYYSLD QGTTWTEYQL EKTILPMQLI STTPDGSGLT FILNGLSMDS
TGGSRWRWND KKETNFVYSI DFSDAFEEKA CVDSDLEKWY VAGGNCINGA KYRFDRRRAD
SKCLMRKIYD DLAYTEEICE KCSDDDYECS YEFVKDSSGK CVADFELLSL SGSCAKAKNG
KISLKPKQRI VNTLCKVDMK IEDVLVPCTE VDSPENPDNI ITVSENKFDS ALLTYKYFDT
ASDESLLMMT LDNEVYVSHD GGKNIKKVNT NREKIVEIVF NPFYSKDAYL FGRDGGLYIT
HDRGQTFTKS QLPETRQLGL KLEFHATKQN TFIYYGGKDC DSMFSEKCHA VAYITTDGGE
TFSEMLNNGI HCKFSGSTFK DPYNEDQIIC QILDSSNGKK KLVSSTNFFK SDSQTETLFE
EVIGFMSTGE FLVVALPHGD DELRAYATLD GKEFAEANLP KDLSDIKQES FTILGSESGS
IFMHLATSQN IQGEFGRLLK SNSNGTSFVS LESAVNRNSA GFVDFEKIQG LEGIVLINVV
ENTDEVERGT TKTKKLKSKI TFNDGSDWSF INPPLKDSNG KKYTCSGKGL KKCSLHLHGY
TERNDIRDTF SSGSAFGMLI AVGNVGEHLL PKDECSTFMT IDGGATWTEV RKGPFQWEYG
DHGGILVLIP DGSESDTLLY STDFGKTWID YKFAGEKIQM RDIVTVPRDS AMRFLIIGQS
NSIRGGTTTV FSVDFSKIFS RQCVYDLDNA SNDDFEFVSF NPVKNQCLFG HQAEYLRKIH
TDCFIGSAPL EESFRIVKNC SCTRNDFECD YNYYKANDGT CKLVEGLTPS DPKDICKKNP
DAYEYFKPTG YRKIPLSTCV DGLNLEGTSS PLPCPGKVEE FRKNHKINGR SFSLLFILPF
LILLGIAWFI YDRGIRRNGG FSRFGEIRLG DEVIEENNVD KAVNNIVRTG LLLTSSVFSG
LQLVKRFIGK SFQSLRERVT GRRGPSYTTL FNDQFLEGAD DLLEGHDEDA NDLTSFLSND
NNFDIDTEDD GNTFAPFREE ASEEDHGPVT GDSSNNEEVS S
