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VPS10_YEAS2
ID   VPS10_YEAS2             Reviewed;        1577 AA.
AC   C7GX93;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   13-OCT-2009, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Vacuolar protein sorting/targeting protein PEP1;
DE   AltName: Full=Carboxypeptidase Y receptor;
DE            Short=CPY receptor;
DE   AltName: Full=Carboxypeptidase Y-deficient protein 1;
DE   AltName: Full=Sortilin VPS10;
DE   AltName: Full=Vacuolar carboxypeptidase sorting receptor VPS10;
DE   AltName: Full=Vacuolar protein sorting-associated protein 10;
DE   AltName: Full=Vacuolar protein-targeting protein 1;
DE   Flags: Precursor;
GN   Name=PEP1; Synonyms=VPS10, VPT1; ORFNames=C1Q_05135;
OS   Saccharomyces cerevisiae (strain JAY291) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=574961;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JAY291;
RX   PubMed=19812109; DOI=10.1101/gr.091777.109;
RA   Argueso J.L., Carazzolle M.F., Mieczkowski P.A., Duarte F.M., Netto O.V.C.,
RA   Missawa S.K., Galzerani F., Costa G.G.L., Vidal R.O., Noronha M.F.,
RA   Dominska M., Andrietta M.G.S., Andrietta S.R., Cunha A.F., Gomes L.H.,
RA   Tavares F.C.A., Alcarde A.R., Dietrich F.S., McCusker J.H., Petes T.D.,
RA   Pereira G.A.G.;
RT   "Genome structure of a Saccharomyces cerevisiae strain widely used in
RT   bioethanol production.";
RL   Genome Res. 19:2258-2270(2009).
CC   -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC       required for the intracellular sorting and delivery of soluble vacuolar
CC       proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC       multiple rounds of sorting by cycling between the late Golgi and a
CC       prevacuolar endosome-like compartment. Binds the Golgi-modified P2 form
CC       of CPY, and this interaction is dependent on the presence of an intact
CC       CPY vacuolar protein sorting signal (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC       {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
CC       Prevacuolar compartment membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}. Note=Cycles between the Golgi apparatus
CC       and the prevacuolar compartment. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC       {ECO:0000305}.
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DR   EMBL; ACFL01000421; EEU04577.1; -; Genomic_DNA.
DR   AlphaFoldDB; C7GX93; -.
DR   SMR; C7GX93; -.
DR   Proteomes; UP000008073; Unassembled WGS sequence.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 3.
DR   InterPro; IPR036278; Sialidase_sf.
DR   InterPro; IPR031777; Sortilin_C.
DR   InterPro; IPR031778; Sortilin_N.
DR   InterPro; IPR006581; VPS10.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   Pfam; PF15902; Sortilin-Vps10; 2.
DR   Pfam; PF15901; Sortilin_C; 2.
DR   SMART; SM00602; VPS10; 2.
DR   SUPFAM; SSF50939; SSF50939; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Golgi apparatus; Membrane; Protein transport; Receptor;
KW   Repeat; Signal; Transmembrane; Transmembrane helix; Transport.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..1577
FT                   /note="Vacuolar protein sorting/targeting protein PEP1"
FT                   /id="PRO_0000407544"
FT   TOPO_DOM        22..1391
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1392..1412
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        1413..1577
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REPEAT          58..68
FT                   /note="BNR 1"
FT   REPEAT          101..111
FT                   /note="BNR 2"
FT   REPEAT          179..187
FT                   /note="BNR 3"
FT   REPEAT          414..423
FT                   /note="BNR 4"
FT   REPEAT          485..495
FT                   /note="BNR 5"
FT   REPEAT          531..541
FT                   /note="BNR 6"
FT   REPEAT          762..771
FT                   /note="BNR 7"
FT   REPEAT          859..869
FT                   /note="BNR 8"
FT   REPEAT          1141..1150
FT                   /note="BNR 9"
FT   REPEAT          1183..1192
FT                   /note="BNR 10"
FT   REGION          1531..1577
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        121
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        168
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        445
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        791
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1008
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1301
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1577 AA;  177554 MW;  8E9210A024ABEB87 CRC64;
     MILLHFVYSL WALLLIPLIN AEEFTPKVTK TIAQDSFEIL SFDDSNTLIR KQDASVTISF
     DDGETWEKVE GIEDEITWIY IDPFNRHDRA VATSMYESRL YITNDQGKSW ERITLPDSEK
     NISSRGCYIE THPLNKNYFL AKCNYCEKTE VDNEENSGDE EGAPVIFNIT HCTDKVFASN
     DGGKSFSEIK SSLERNENSA ISISDCGFAK TGKDSDLESS DTSIICLFQN MQLIMDEFSS
     PYTESKLVLT TDWGKSLKEF DQFKDKVVNG YRILKSHMVV ITQGDRYNDM SSMDVWVSND
     LSNFKMAYMP TQLRHSMQGE IYEDAMGRII LPMSRERSDQ EEDKGIVSEI LISDSQGLKF
     SPIPWTANEV FGYINLYQPT YLKGTMIASL YPLSRRRNRK GKAKGVKNKG VTKISVDNGL
     TWTVLKVVDP DNADSFDCDI TDFENCSLQN MFYTREGSTP TAGILMTTGI VGDGSVFDWG
     DQRTFISRDG GLTWKLAFDF PCLYAVGDYG NVIVAIPYNA DEDDDPQSEF YYSLDQGKTW
     TEYQLETTIY PNEVMNTTPD GSGAKFILNG FTLAHMDGTT NFIYAIDFST AFNDKTCEEN
     DFEDWNLAEG KCVNGVKYKI RRRKQDAQCL VKKVFEDLQL FETACDKCTE ADYECAFEFV
     RDATGKCVPD YNLIVLSDVC DKTKKKTVPV KPLQLVKGDK CKKPMTVKSV DISCEGVPKK
     GTNDKEIVVT ENKFDFKIQF YQYFDTVTDE SLLMINSRGE AYISHDGGQT IRRFDSNGET
     IIEVVFNPYY NSSAYLFGSK GSIFSTHDRG YSFMTAKLPE ARQLGMPLDF NAKAQDTFIY
     YGGKNCESIL SPECHAVAYL TNDGGETFTE MLDNAIHCEF AGSLFKYPSN EDMVMCQVKE
     KSSQTRSLVS STDFFQDDKN TVFENIIGYL STGGYIIVAV PHENNELRAY VTIDGTEFAE
     AKFPYDEDVG KQEAFTILES EKGSIFLHLA TNLVPGRDFG NLLKSNSNGT SFVTLEHAVN
     RNTFGYVDFE KIQGLEGIIL TNIVSNSDKV AENKEDKQLK TKITFNEGSD WNFLKPPKRD
     SEGKKFSCSS KSLDECSLHL HGYTERKDIR DTYSSGSALG MMFGVGNVGP NLLPYKECST
     FFTTDGGETW AEVKKTPHQW EYGDHGGILV LVPENSETDS ISYSTDFGKT WKDYKFCADK
     VLVKDITTVP RDSALRFLLF GEAADIGGSS FRTYTIDFRN IFERQCDFDI TGKESADYKY
     SPLSSKSNCL FGHQTEFLRK TDENCFIGNI PLSEFSRNIK NCSCTRQDFE CDYNFYKAND
     GTCKLVKGLS PANAADVCKK EPDLIEYFES SGYRKIPLST CEGGLKLDAP SSPHACPGKE
     KEFKEKYSVS AGPFAFIFIS ILLIIFFAAW FVYDRGIRRN GGFARFGEIR LGDDGLIENN
     NTDRVVNNIV KSGFYVFSNI GSLLQHTKTN IAHVISKIRG RFGNRTGPSY SSLIHDQFLD
     EADDLLAGHD EDANDLSSFM DQGSNFEIEE DDVPTLEEEH TSYTDQPTTT DVPDALPEGN
     EENIDRPDST APSNENQ
 
 
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