VPS10_ZYGRC
ID VPS10_ZYGRC Reviewed; 1586 AA.
AC C5DU19;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 1.
DT 03-AUG-2022, entry version 58.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10;
DE AltName: Full=Carboxypeptidase Y receptor;
DE Short=CPY receptor;
DE AltName: Full=Sortilin VPS10;
DE AltName: Full=Vacuolar carboxypeptidase sorting receptor VPS10;
DE Flags: Precursor;
GN Name=VPS10; OrderedLocusNames=ZYRO0C13178g;
OS Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568
OS / NRRL Y-229) (Candida mogii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Zygosaccharomyces.
OX NCBI_TaxID=559307;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 2623 / CBS 732 / BCRC 21506 / NBRC 1130 / NCYC 568 / NRRL
RC Y-229;
RX PubMed=19525356; DOI=10.1101/gr.091546.109;
RG The Genolevures Consortium;
RA Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT "Comparative genomics of protoploid Saccharomycetaceae.";
RL Genome Res. 19:1696-1709(2009).
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
CC Prevacuolar compartment membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}. Note=Cycles between the Golgi apparatus
CC and the prevacuolar compartment. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC {ECO:0000305}.
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DR EMBL; CU928175; CAR27280.1; -; Genomic_DNA.
DR RefSeq; XP_002496213.1; XM_002496168.1.
DR AlphaFoldDB; C5DU19; -.
DR SMR; C5DU19; -.
DR STRING; 559307.C5DU19; -.
DR PRIDE; C5DU19; -.
DR EnsemblFungi; CAR27280; CAR27280; ZYRO0C13178g.
DR GeneID; 8203437; -.
DR KEGG; zro:ZYRO0C13178g; -.
DR HOGENOM; CLU_000700_0_0_1; -.
DR InParanoid; C5DU19; -.
DR Proteomes; UP000008536; Chromosome C.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
PE 3: Inferred from homology;
KW Glycoprotein; Golgi apparatus; Membrane; Protein transport; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..1586
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /id="PRO_0000407548"
FT TOPO_DOM 20..1374
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 1375..1395
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1396..1586
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 54..64
FT /note="BNR 1"
FT REPEAT 401..410
FT /note="BNR 2"
FT REPEAT 473..483
FT /note="BNR 3"
FT REPEAT 519..529
FT /note="BNR 4"
FT REPEAT 841..852
FT /note="BNR 5"
FT REPEAT 1123..1133
FT /note="BNR 6"
FT REPEAT 1164..1174
FT /note="BNR 7"
FT REGION 1511..1586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1568..1586
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 990
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1284
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1586 AA; 178792 MW; 74D36A464654F19C CRC64;
MLIRLLFCIW AFWFKVIAAE FQPKVTRTSD STVFYVAAFD DSTTLLRVQE NGMFISFDNG
GTWQEPNGAP SGVMMVDIDE HHRHDRAVAQ TKDGQFYLTE DQGKHWRSLA SPIDSKEYLY
CDLDTHPLRR DYFLVRCTKC PEMEMGSSQL IDLHKRDSFM PSCQEFSYVS NNGGKDFKKI
ESPKHEPSPD TEYLGVTCEF ASKSVESTLP SSRDLIYCFD GKMDKWFDND FTFQTSGVLF
YTDDFGKSSK VVDQFKDLTV SNFEVLNSHI LVYTLEDRFN RWSASNLWVS SDGFKFSKAF
LPTILRDMDT YGTTEDGLGR IILPLYVESE DDNRASQILI SDSSGLQFRV LELTPEDNME
FSILEASKTL KGTMWADLMS LVKGPRYSGH PSFDFHQVSK ISFDYGSTWS NLKVVASPNH
RKDLFTCDIN DVDHCSLHKL FGDSLPTETA GILMTLGTVG DGSENSWENL MTFISRDGGK
TWEVAFEYPC QFAFGDLGNV IVAMPFSPDE DSDPQSEFYY SLDQGKTWKE YQLEVPIMPT
ELISTTPDSS GLNFIISSFS LTRDNETPPG SFFYTIDFSD AFNGEVCGPK EFESWYLAGG
ECVNGAKYSY SRRKQNSQCL VRKLFEDLVL TEEICDECTD KDYECSFGFS RDSNGVCKPD
FKPLSFSPEC MKSGKDSAKV KPMTKLPGNK CRKELKIEPL EVPCTQGHTI LLTENNFNSK
IQMYQYFDTK QDETLIIDTA RNGVYISHDS GQIVKRFDPG ENIVEIVFNT YHNSYAYLFG
ESGKLYVTAN RCQSFAIAEL PHSRQLGLPL EFHAKDPNTF IYYGGKNCKD MFSPSCHPVA
YITTDGGKSF TKLLDNAIHC EFAGSLFKHP VDENLIYCQV KEPQTRKRTL MSSTDLFRND
KKVVLEKIIG YMNTGEFIVA AVPYGENELR AYVTVDGAEL AEAKFPQDLT ATKQEAFTVL
GSETGSVFFH LTTFDEPGYE YGALLKSNSN GTSFVRLQSA VNRNLFGMVD FEKVQALEGI
ILINVVDNFE KVGTKTEEKK LKSMITFNDG SDWSYIRAPP KDSDSNSYGC NTKQLEKCSL
HLHGYTERED VRDTSFSGSA FGMLIGIGNV GEYLLPEDQC STFFSRDGGE TWREIKKGAY
QWEFGDHGGV IVLVPKNSLT DRIFYSIDMG ETWSDYILQG AKVYIQDIVT VPGDSALRFL
LIASSSSVTG GSTKTFTVDF SNVFERQCSL NPDRPDNEDF KFFSLGQSDS KCLFGHQERY
LMKDNYDCFV GNAPLSEFRE ITKNCSCTRA DFECDYNYVK ARDGTCTLVE GLSPAGPSDI
CKKQPELIEY FQPTGYRKIP LSTCVGGLTL DGVLSPLPCP GKEKEFKELH GVKSAPYFFT
FLVFFLVLLV IAWFVYDRGV RRNGGFARFG EIRLDGDDLI ENNNTDKMVN SIVKSGFYAA
SAIFSSYQLL KRSMGRAVWK LSEKFGRRSG PTYSSLLHDQ FLDEADDLLT GHDEDANDLG
SFLAEQGNFE IEDEDNELPP LRAPFTDEPH MESTETAEPV EPVEPVEPVE SAEPTETAEP
SSSPPQENYN DEHHDNKDDE QDLGAQ
