VPS11_DICDI
ID VPS11_DICDI Reviewed; 952 AA.
AC Q54YP4;
DT 23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 113.
DE RecName: Full=Vacuolar protein sorting-associated protein 11 homolog;
GN Name=vps11; Synonyms=pep5; ORFNames=DDB_G0278141;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: May play a role in vesicle-mediated protein trafficking.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Peripheral
CC membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the VPS11 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAFI02000023; EAL68243.1; -; Genomic_DNA.
DR RefSeq; XP_642158.1; XM_637066.1.
DR AlphaFoldDB; Q54YP4; -.
DR STRING; 44689.DDB0234135; -.
DR PaxDb; Q54YP4; -.
DR PRIDE; Q54YP4; -.
DR EnsemblProtists; EAL68243; EAL68243; DDB_G0278141.
DR GeneID; 8621365; -.
DR KEGG; ddi:DDB_G0278141; -.
DR dictyBase; DDB_G0278141; vps11.
DR eggNOG; KOG2114; Eukaryota.
DR HOGENOM; CLU_001287_0_1_1; -.
DR InParanoid; Q54YP4; -.
DR OMA; MRPQSTM; -.
DR PhylomeDB; Q54YP4; -.
DR PRO; PR:Q54YP4; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0030897; C:HOPS complex; ISS:dictyBase.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IBA:GO_Central.
DR GO; GO:0007032; P:endosome organization; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0048284; P:organelle fusion; IBA:GO_Central.
DR GO; GO:0042144; P:vacuole fusion, non-autophagic; ISS:dictyBase.
DR GO; GO:0007033; P:vacuole organization; IBA:GO_Central.
DR GO; GO:0006904; P:vesicle docking involved in exocytosis; IBA:GO_Central.
DR GO; GO:0016192; P:vesicle-mediated transport; ISS:dictyBase.
DR Gene3D; 1.25.40.10; -; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR016528; VPS11.
DR InterPro; IPR024763; VPS11_C.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR23323:SF24; PTHR23323:SF24; 1.
DR Pfam; PF00637; Clathrin; 2.
DR Pfam; PF12451; VPS11_C; 1.
DR PIRSF; PIRSF007860; VPS11; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50236; CHCR; 2.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Coiled coil; Membrane; Metal-binding; Protein transport;
KW Reference proteome; Repeat; Transport; Vacuole; Zinc; Zinc-finger.
FT CHAIN 1..952
FT /note="Vacuolar protein sorting-associated protein 11
FT homolog"
FT /id="PRO_0000350872"
FT REPEAT 416..563
FT /note="CHCR 1"
FT REPEAT 629..783
FT /note="CHCR 2"
FT ZN_FING 869..905
FT /note="RING-type; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT REGION 608..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 837..868
FT /evidence="ECO:0000255"
SQ SEQUENCE 952 AA; 108280 MW; 1ACFC1EBA2523335 CRC64;
MNNWKRFTFF DIETVKQVEK EDGSSLQKLS ITCTTSGRGS LIIGDAEGFI NFVDREFGIS
SFQAYQQSVS LIYQLKERNF LSSVGHDDIG GAAILKIWNL DKTDKNEQPI CVRSIKLEKS
VTVTCFTLLE DLSQIIVGLA NGEIIIIRAD IFRDKVIKQK IIKVPNDSPI TGLGFFPTKS
QQSASAGAVL FVVTTTHVIT YHTAHKDQET IIDDEGGDIG SFLMSDDGSP IIARSDAIYF
YNVDGRGPCF GFTGVKTKVL WFRSYLVVIG YDTNNTNALF PGAVVGGQNS IGGLGSQTGS
IGSPSVMVQN TKNNVLNIYD LKNKYIGFTE KFDTVSHICS EWGSIFIFGA DGKVFQLEEK
DTQTKLETLF KKHSYQVAID LAKSQHYDNS AIADVYREYG DRLYAKGDYD GAITQYLCTI
GQLEPSYVIR KFLDAQRIHN LTSYIQALHE KNLATANHTT LLLNCYTKLK DVKKLDHFIM
TDNGTFDVET AIKVCRQGGY FDRALFLASK HSRHDWYLKI LLEDLNEYRK ALDYIQTLDW
EEADKNLKKY GKQLVSEIPE ETTGVLMKLC TNYQPVQAFD SLTALNLNGL TISNQTTTTT
TVTNVTNNNN QNNNSNNNNQ NNNNNNNNNI GFKQKSAPEE FIHIFVSQAD WLVKFLEYMV
QQGNNESSLI YNTLLELYLR DDVNQTDDER IKRKAKAYEF LTNPKSKFDQ DHALILVQVH
NWKEGVLYLY EKLELFNEII EYHMENNDYD GLIKACKRYG VKDPNLWVRA LSFFSTNKQD
CQDEIIEVLT NIDKENLIPP LLVIQILSQN KNTTLAVIKD YISRRLSQET QQIDKDYTQI
RQYADETEKM RHEINELRTN SKIFQQTKCI ACLLALDLPS VHFLCQHSFH QRCLGENERE
CPSCAGANKR IQEIKRSQAD SANQHDQFFK LLRSSPDGFT TVSEYFGRGI LN
