ID   VPS16_DICDI             Reviewed;         832 AA.
AC   Q55C58;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 2.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Vacuolar protein sorting-associated protein 16 homolog;
GN   Name=vps16; ORFNames=DDB_G0270754;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: May play a role in vesicle-mediated protein trafficking to
CC       endosomal/lysosomal compartments and in membrane docking/fusion
CC       reactions. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the VPS16 family. {ECO:0000305}.
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DR   EMBL; AAFI02000005; EAL72727.2; -; Genomic_DNA.
DR   RefSeq; XP_646623.2; XM_641531.2.
DR   AlphaFoldDB; Q55C58; -.
DR   SMR; Q55C58; -.
DR   STRING; 44689.DDB0234137; -.
DR   PaxDb; Q55C58; -.
DR   PRIDE; Q55C58; -.
DR   EnsemblProtists; EAL72727; EAL72727; DDB_G0270754.
DR   GeneID; 8617595; -.
DR   KEGG; ddi:DDB_G0270754; -.
DR   dictyBase; DDB_G0270754; vps16.
DR   eggNOG; KOG2280; Eukaryota.
DR   HOGENOM; CLU_008909_1_0_1; -.
DR   InParanoid; Q55C58; -.
DR   OMA; KIYVHWA; -.
DR   PhylomeDB; Q55C58; -.
DR   PRO; PR:Q55C58; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0015629; C:actin cytoskeleton; ISS:dictyBase.
DR   GO; GO:0005768; C:endosome; IBA:GO_Central.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030897; C:HOPS complex; ISS:dictyBase.
DR   GO; GO:0003779; F:actin binding; ISS:dictyBase.
DR   GO; GO:0016197; P:endosomal transport; IBA:GO_Central.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0042144; P:vacuole fusion, non-autophagic; ISS:dictyBase.
DR   GO; GO:0016192; P:vesicle-mediated transport; ISS:dictyBase.
DR   Gene3D; 1.10.150.780; -; 1.
DR   InterPro; IPR016534; VPS16.
DR   InterPro; IPR006925; Vps16_C.
DR   InterPro; IPR038132; Vps16_C_sf.
DR   InterPro; IPR006926; Vps16_N.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR12811; PTHR12811; 1.
DR   Pfam; PF04840; Vps16_C; 1.
DR   Pfam; PF04841; Vps16_N; 1.
DR   PIRSF; PIRSF007949; VPS16; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   3: Inferred from homology;
KW   Endosome; Membrane; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..832
FT                   /note="Vacuolar protein sorting-associated protein 16
FT                   homolog"
FT                   /id="PRO_0000328323"
SQ   SEQUENCE   832 AA;  94870 MW;  C3CE0251DE35AE2F CRC64;
     MIAAQWKIIG NSTYIKKEIY SMSWDVDLKQ QVSVGSPFAG PIAVMRDSSK FVEMNSQNMK
     PYLKIFTASG DLISQMIWDS SKNIVAMDWI EKERLVIVLQ NATVLIFNVF CEQMTQFSLG
     DIVREEEILE CKIWSDGIVV LTSASQLYSV PSINDFFVES GRVIRLPPLP EEPKARPEWA
     ILEPQFSLSQ SIEIFMSING TLYLIDEDKV ESQLEATEPI QKMVVSPCGK KLACFDTKGT
     LLILKTDGST TNPDRMDTKA TKSPVLKWCG SDGVMMYWDS IKDPILFYFS KGDSWAKFTL
     DQPVSLVTEI DGLRIISDTT SEFFHKVSDV TIDIFKIGTT SPASILYDAT DHFISKSPQA
     DESIRSINDQ LEDAVNDCIL AAGFEFNGGE QSKLLKAASF GKCFLENYNP SQFVTMCRSL
     RVLNAVRHHE IGIPLSIKQY YHIGIEELID RLISRRKHLL AWRICDYLKI KSDVVLNHWA
     CTKVRTDIPD QELGKIIIKK LESVPGISFA NIASAAYLAG RSKLATKLLE YEPKAAEQVP
     PLIKMGESGL ALNKAIESGD TDLVYLVLLA MQRSLPLADF LELTFSKVVA LDLLISMCKQ
     KNDFPLLREI YHIKDQSKEM GNIYLQEALS SHPSQLDQRI KAYNKSIEHY HHSKDKDDQA
     TSKFIDDQIK LEMLQKELET NLQDESFVGI SINDTIYKLI TMNQPKKAQS IRSEFKVPDK
     RFWWIKIKAL SIMNDWEELM KFSKEKKSPI GYEPFVEVCL DQKNQIEALK YIPKITDILP
     KIQFYIQIGY FREAADIAFK EKNFDLLNLI SRKCTNNEIL NIIEQMKSQI RR