VPS16_SCHPO
ID VPS16_SCHPO Reviewed; 835 AA.
AC Q9UT38;
DT 15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=Probable vacuolar protein sorting-associated protein 16 homolog;
GN Name=vps16; ORFNames=SPAC824.05;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Essential for vacuolar protein sorting. Required for vacuole
CC biogenesis, stability and to maintain vacuole morphology (By
CC similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the VPS16 family. {ECO:0000305}.
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DR EMBL; CU329670; CAB57335.1; -; Genomic_DNA.
DR PIR; T39106; T39106.
DR RefSeq; NP_593444.1; NM_001018877.2.
DR AlphaFoldDB; Q9UT38; -.
DR SMR; Q9UT38; -.
DR STRING; 4896.SPAC824.05.1; -.
DR iPTMnet; Q9UT38; -.
DR MaxQB; Q9UT38; -.
DR PaxDb; Q9UT38; -.
DR PRIDE; Q9UT38; -.
DR EnsemblFungi; SPAC824.05.1; SPAC824.05.1:pep; SPAC824.05.
DR GeneID; 2541533; -.
DR KEGG; spo:SPAC824.05; -.
DR PomBase; SPAC824.05; vps16.
DR VEuPathDB; FungiDB:SPAC824.05; -.
DR eggNOG; KOG2280; Eukaryota.
DR HOGENOM; CLU_008909_1_0_1; -.
DR InParanoid; Q9UT38; -.
DR OMA; KIYVHWA; -.
DR PhylomeDB; Q9UT38; -.
DR PRO; PR:Q9UT38; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0033263; C:CORVET complex; ISO:PomBase.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0030897; C:HOPS complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:1902500; C:vacuolar HOPS complex; ISS:PomBase.
DR GO; GO:0003779; F:actin binding; IBA:GO_Central.
DR GO; GO:0016197; P:endosomal transport; IBA:GO_Central.
DR GO; GO:0006895; P:Golgi to endosome transport; ISS:PomBase.
DR GO; GO:0045324; P:late endosome to vacuole transport; ISS:PomBase.
DR GO; GO:0006623; P:protein targeting to vacuole; ISS:PomBase.
DR GO; GO:0042144; P:vacuole fusion, non-autophagic; ISS:PomBase.
DR GO; GO:0048278; P:vesicle docking; ISS:PomBase.
DR Gene3D; 1.10.150.780; -; 1.
DR InterPro; IPR016534; VPS16.
DR InterPro; IPR006925; Vps16_C.
DR InterPro; IPR038132; Vps16_C_sf.
DR InterPro; IPR006926; Vps16_N.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR12811; PTHR12811; 1.
DR Pfam; PF04840; Vps16_C; 1.
DR Pfam; PF04841; Vps16_N; 1.
DR PIRSF; PIRSF007949; VPS16; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
PE 3: Inferred from homology;
KW Protein transport; Reference proteome; Transport.
FT CHAIN 1..835
FT /note="Probable vacuolar protein sorting-associated protein
FT 16 homolog"
FT /id="PRO_0000065890"
SQ SEQUENCE 835 AA; 95189 MW; B309388693E3EC5A CRC64;
MEPSIKYPIY EWELLQDTYY QKSAIGKAEW EYIDPVDFMF AVAPCGGAIA ITRSESNLQS
NYKYDQVPMY SICVFCLSGQ LLQTLTWDKT SLVGMGWNEN EELIVVSKQG QVRVYNLLGE
FHQFSLGKGV ENIGIRECQF SEGGVFALLQ NDTFISITGF EEPWRKTYAS IPFNTLEYYN
IDSWALIPNP FSPDLGMDIV VTVGPHILQI DEQDSQLHSI SSLQHVSHIS ISPNARYLAL
YESVGKVRVI SSDFSKELLD LRLPETVAEA SLKQMAWCGN DAVVLVHENL LTLVGPFGGS
VPYLYNHTPI VSTEVDGVRI LTKDSSEFLR KVPAPLENIF HIGSKTPGAK LVEAFQKMKL
KSVFAEKMLL ELKDELHDAV DTCVQASLNE FSIEWQKVLL EAASLGKNSL RMYNHQEYVD
VCRELRVLNA ARDPNVGIYI THEEYLHLGL ERLIQRFSCR QLYGLAVQAS MWMQIPCDWV
YIQWAQTYIK QSSEPEEVVL DNIVKRLSSR KYISYEKIAR TAYQEGRLIL STKLLDFEPL
AKHQVMLLLN MEAYEQALKK VIETMDNNLI IYVVLQIKQQ MAIASFFQIL NEYPDAVKVY
VEFAKKNDRK TLHDFFYQDD NKQGIAVLAV EDTLKTATVN QRITSLKSAA KVCSESKELS
LEEKCLGDEI KLLQLQQTYE DQFTGNFVGL TVNEVVVKLI QINQTQRANK LRSDFQIPEK
RFAWLKLRAL VAIRDWVQIE QWAGSMRRSP IGFEPFVTEI LSAGNKKEAA KYIPRCTQLT
TQEKVDMWVQ VGDVKSASEE AAKSKSGSVL GDLLERVQTM PESRFVQNAL DQLRR
