VPS17_SCHPO
ID VPS17_SCHPO Reviewed; 549 AA.
AC Q9URW7;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Vacuolar protein sorting-associated protein 17;
GN Name=vps17; ORFNames=SPAPJ696.01c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION.
RX PubMed=16622069; DOI=10.1099/mic.0.28627-0;
RA Iwaki T., Hosomi A., Tokudomi S., Kusunoki Y., Fujita Y., Giga-Hama Y.,
RA Tanaka N., Takegawa K.;
RT "Vacuolar protein sorting receptor in Schizosaccharomyces pombe.";
RL Microbiology 152:1523-1532(2006).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Plays a role in vesicular protein sorting. Required for the
CC endosome-to-Golgi retrieval of the vacuolar protein sorting receptor
CC pep1/vps10. Component of the membrane-associated retromer complex which
CC is essential in endosome-to-Golgi retrograde transport. The vps29-
CC vps26-vps35 subcomplex may be involved in cargo selection.
CC {ECO:0000269|PubMed:16622069}.
CC -!- SUBUNIT: Component of the retromer complex which consists of vps29,
CC vps6, vps35, vps5 and vps17. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the VPS17 family. {ECO:0000305}.
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DR EMBL; CU329670; CAB62421.1; -; Genomic_DNA.
DR PIR; T50295; T50295.
DR RefSeq; NP_593047.1; NM_001018446.2.
DR AlphaFoldDB; Q9URW7; -.
DR SMR; Q9URW7; -.
DR BioGRID; 279747; 144.
DR STRING; 4896.SPAPJ696.01c.1; -.
DR iPTMnet; Q9URW7; -.
DR MaxQB; Q9URW7; -.
DR PaxDb; Q9URW7; -.
DR PRIDE; Q9URW7; -.
DR EnsemblFungi; SPAPJ696.01c.1; SPAPJ696.01c.1:pep; SPAPJ696.01c.
DR GeneID; 2543324; -.
DR KEGG; spo:SPAPJ696.01c; -.
DR PomBase; SPAPJ696.01c; vps17.
DR VEuPathDB; FungiDB:SPAPJ696.01c; -.
DR eggNOG; KOG2273; Eukaryota.
DR HOGENOM; CLU_028982_0_0_1; -.
DR InParanoid; Q9URW7; -.
DR OMA; LMRDDEM; -.
DR PhylomeDB; Q9URW7; -.
DR PRO; PR:Q9URW7; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0005628; C:prospore membrane; IDA:PomBase.
DR GO; GO:0030904; C:retromer complex; IMP:PomBase.
DR GO; GO:0030905; C:retromer, tubulation complex; IBA:GO_Central.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IBA:GO_Central.
DR GO; GO:0032120; P:ascospore-type prospore membrane formation; IMP:PomBase.
DR GO; GO:0006886; P:intracellular protein transport; IMP:PomBase.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IMP:PomBase.
DR GO; GO:0016192; P:vesicle-mediated transport; IMP:PomBase.
DR CDD; cd06891; PX_Vps17p; 1.
DR Gene3D; 1.20.1270.60; -; 1.
DR Gene3D; 3.30.1520.10; -; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR014461; Retromer_complex_Vps17.
DR InterPro; IPR037907; Vps17_PX.
DR Pfam; PF00787; PX; 1.
DR PIRSF; PIRSF011791; Vps17; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF64268; SSF64268; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Nucleus; Protein transport; Reference proteome;
KW Transport.
FT CHAIN 1..549
FT /note="Vacuolar protein sorting-associated protein 17"
FT /id="PRO_0000339647"
FT DOMAIN 96..213
FT /note="PX"
FT REGION 470..540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 250..281
FT /evidence="ECO:0000255"
FT COMPBIAS 477..521
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 549 AA; 60921 MW; F892A29B80380CD5 CRC64;
MSSQHSTDDL MNSHVFSGGF STLDDKGFQD VPIHTDMPGS ISVEPSSEDA NVGSVNGNIN
ETPVFEADRL IAEATMNPSA ASSTTGENSI SQTGSGPFLR IRIVDIEAEN SKDPVIKMNV
QTTLPAYRSK LYKNVRRTHA EFKKFAKYLI STHPECLIPA VPEAKTSVSS GIKEDLIYLK
SGLQSWLNYV STNPNLLYDP ELQLFVESDY GYSPLINTGN PTSGLKRKAL KQFPLPPDPC
QALANLRPIV KSFYKNAKDA EIKLEKLVNR KQSLALTHAD LGQSLIDYSV EEQHNGLANA
LNRVGKMLQA ISDVRIMQSS KQLVTLADSL CYASDNAFVV KEILSNRHIL MRDLISSKNQ
TNSYLSAANR LQDSPKISKA RTDDALQALE VARVHEKLLS DKVDFVTLNL VKESKTYTKK
TSVSLQKAIR EYVEKEAYYE RRLLSIMESI RPHIRNIDPF GGLSRLGREE YPRRLSNPPP
SQKTNQDAWT NRKRPGYSSS FDGSSQSTFN PSNNDGAHNT SENADELVEP PIGNERLDPK
SVANLLNAI
