VPS1_SCHPO
ID VPS1_SCHPO Reviewed; 678 AA.
AC Q9URZ5; O14309;
DT 06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2002, sequence version 2.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Vacuolar protein sorting-associated protein 1;
GN Name=vps1; ORFNames=SPAC767.01c, SPAC9G1.14c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC superfamily. Dynamin/Fzo/YdjA family. {ECO:0000255|PROSITE-
CC ProRule:PRU01055}.
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DR EMBL; CU329670; CAB11498.1; -; Genomic_DNA.
DR PIR; T50256; T50256.
DR RefSeq; XP_001713062.1; XM_001713010.2.
DR AlphaFoldDB; Q9URZ5; -.
DR SMR; Q9URZ5; -.
DR BioGRID; 279175; 60.
DR STRING; 4896.SPAC767.01c.1; -.
DR iPTMnet; Q9URZ5; -.
DR MaxQB; Q9URZ5; -.
DR PaxDb; Q9URZ5; -.
DR PRIDE; Q9URZ5; -.
DR EnsemblFungi; SPAC767.01c.1; SPAC767.01c.1:pep; SPAC767.01c.
DR PomBase; SPAC767.01c; vps1.
DR VEuPathDB; FungiDB:SPAC767.01c; -.
DR eggNOG; KOG0446; Eukaryota.
DR HOGENOM; CLU_008964_5_2_1; -.
DR InParanoid; Q9URZ5; -.
DR OMA; AMDPTNK; -.
DR PhylomeDB; Q9URZ5; -.
DR Reactome; R-SPO-169911; Regulation of Apoptosis.
DR Reactome; R-SPO-196025; Formation of annular gap junctions.
DR Reactome; R-SPO-437239; Recycling pathway of L1.
DR Reactome; R-SPO-75153; Apoptotic execution phase.
DR Reactome; R-SPO-8856828; Clathrin-mediated endocytosis.
DR PRO; PR:Q9URZ5; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:0005794; C:Golgi apparatus; HDA:PomBase.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR GO; GO:0005777; C:peroxisome; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:1990606; F:membrane scission GTPase motor activity; TAS:PomBase.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0006897; P:endocytosis; ISO:PomBase.
DR GO; GO:0007031; P:peroxisome organization; IGI:PomBase.
DR GO; GO:0042144; P:vacuole fusion, non-autophagic; IMP:PomBase.
DR GO; GO:0099050; P:vesicle scission; NAS:PomBase.
DR CDD; cd08771; DLP_1; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR022812; Dynamin.
DR InterPro; IPR001401; Dynamin_GTPase.
DR InterPro; IPR019762; Dynamin_GTPase_CS.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR000375; Dynamin_stalk.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR003130; GED.
DR InterPro; IPR020850; GED_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11566; PTHR11566; 1.
DR Pfam; PF01031; Dynamin_M; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF02212; GED; 1.
DR PRINTS; PR00195; DYNAMIN.
DR SMART; SM00053; DYNc; 1.
DR SMART; SM00302; GED; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00410; G_DYNAMIN_1; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
DR PROSITE; PS51388; GED; 1.
PE 3: Inferred from homology;
KW GTP-binding; Motor protein; Nucleotide-binding; Reference proteome.
FT CHAIN 1..678
FT /note="Vacuolar protein sorting-associated protein 1"
FT /id="PRO_0000206587"
FT DOMAIN 24..311
FT /note="Dynamin-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT DOMAIN 592..678
FT /note="GED"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00720"
FT REGION 34..41
FT /note="G1 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT REGION 60..62
FT /note="G2 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT REGION 71..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 153..156
FT /note="G3 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT REGION 222..225
FT /note="G4 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT REGION 252..255
FT /note="G5 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT BINDING 34..41
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255"
FT BINDING 153..157
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255"
FT BINDING 222..225
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255"
SQ SEQUENCE 678 AA; 75791 MW; E2CB9CA2E2F2343B CRC64;
MDPSLIKVVN QLQEAFSTVG VQNLIDLPQI TVVRSQSSGK SSVLENIVGR DFLPRGTGIV
TRRPLVLQLI NRPSASGKNE ETTTDSDGKD QNNSSEWGEF LHLPGQKFFE FEKIREEIVR
ETEEKTGKNV GISSVPIYLR IYSPHVLTLT LVDLPGLTKV PVGDQPRDIE KQIREMVLKY
ISKNNAIILA VNAANTDLAN SDGLKLAREV DPEGLRTIGV LTKVDLMDKG TDVVDILAGR
VIPLRLGYVP VINRGQKDIE GKKSIRIALE AERNFFETHP SYGSKAQYCG TPFLARKLNM
ILMHHIRNTL PEIKVRINAA LAKYQAELHS LGDTPVGDNS SIVLNLITDF CNEYRTVVDG
RSEELSATEL SGGARIAFVF HEIFSNGIQA IDPFDEVKDS DIRTILYNSS GPSPSLFMGT
AAFEVIVKQQ IKRLEDPSLK CVSLIYDELV RILNQLLQRP IFKRYPLLKD EFYKVVIGFF
RKCMQPTNTL VMDMVAMEGS YINTVHPDFL SGHQAMAIVQ SQNSKPIPVD PKTGKALTNN
PVPPVETSSS SGQNFFGSFF GSKNKKRLAA MEPPPPVLRA STTLSDREKT DTEVIKLLIM
SYFNIVKRTL ADMVPKSISL KMIKYSKEHI QHELLEQLYK SQAFDKLLQE SEVTVQRRKE
CEQMVESLLQ ASEIVSNV
