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VPS24_SCHPO
ID   VPS24_SCHPO             Reviewed;         231 AA.
AC   O14296;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Vacuolar protein sorting-associated protein 24;
GN   Name=vps24; ORFNames=SPAC9E9.14;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   FUNCTION.
RX   PubMed=17660439; DOI=10.1099/mic.0.2007/006072-0;
RA   Iwaki T., Onishi M., Ikeuchi M., Kita A., Sugiura R., Giga-Hama Y.,
RA   Fukui Y., Takegawa K.;
RT   "Essential roles of class E Vps proteins for sorting into multivesicular
RT   bodies in Schizosaccharomyces pombe.";
RL   Microbiology 153:2753-2764(2007).
CC   -!- FUNCTION: Class E VPS protein implicated in concentration and sorting
CC       of cargo proteins of the multivesicular body (MVB) for incorporation
CC       into intralumenal vesicles. The lumenal sequestrated membrane proteins
CC       will be targeted into the vacuole after fusion of the endosome with the
CC       vacuole. {ECO:0000269|PubMed:17660439}.
CC   -!- SUBUNIT: Component of the endosomal sorting required for transport
CC       complex III (ESCRT-III). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}. Endomembrane system {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SNF7 family. {ECO:0000305}.
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DR   EMBL; CU329670; CAB16412.1; -; Genomic_DNA.
DR   PIR; T39221; T39221.
DR   RefSeq; NP_594587.1; NM_001020016.2.
DR   AlphaFoldDB; O14296; -.
DR   SMR; O14296; -.
DR   BioGRID; 278706; 4.
DR   STRING; 4896.SPAC9E9.14.1; -.
DR   iPTMnet; O14296; -.
DR   MaxQB; O14296; -.
DR   PaxDb; O14296; -.
DR   PRIDE; O14296; -.
DR   EnsemblFungi; SPAC9E9.14.1; SPAC9E9.14.1:pep; SPAC9E9.14.
DR   GeneID; 2542234; -.
DR   KEGG; spo:SPAC9E9.14; -.
DR   PomBase; SPAC9E9.14; vps24.
DR   VEuPathDB; FungiDB:SPAC9E9.14; -.
DR   eggNOG; KOG3229; Eukaryota.
DR   HOGENOM; CLU_069208_0_2_1; -.
DR   InParanoid; O14296; -.
DR   OMA; INEMMDD; -.
DR   PhylomeDB; O14296; -.
DR   Reactome; R-SPO-1632852; Macroautophagy.
DR   Reactome; R-SPO-917729; Endosomal Sorting Complex Required For Transport (ESCRT).
DR   Reactome; R-SPO-9668328; Sealing of the nuclear envelope (NE) by ESCRT-III.
DR   PRO; PR:O14296; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0000815; C:ESCRT III complex; ISO:PomBase.
DR   GO; GO:0005771; C:multivesicular body; IBA:GO_Central.
DR   GO; GO:0032509; P:endosome transport via multivesicular body sorting pathway; IBA:GO_Central.
DR   GO; GO:0045324; P:late endosome to vacuole transport; IMP:PomBase.
DR   GO; GO:0015031; P:protein transport; IBA:GO_Central.
DR   GO; GO:0043328; P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IMP:PomBase.
DR   InterPro; IPR005024; Snf7_fam.
DR   PANTHER; PTHR10476; PTHR10476; 1.
DR   Pfam; PF03357; Snf7; 1.
PE   3: Inferred from homology;
KW   Endosome; Membrane; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..231
FT                   /note="Vacuolar protein sorting-associated protein 24"
FT                   /id="PRO_0000362997"
FT   REGION          184..214
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        195..209
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   231 AA;  26365 MW;  685F71EB54232069 CRC64;
     MQTVRSYFFG PTPQEQNRKW QSIIRKEQRQ LDRQVYHLKA GRKKAEVQLK QLAKQSDITN
     MRILAKEIAR ANRHGKRLAE SKALLGSLSL QLNDQMAMLK IQGTMQSSTK IMQDVSSLIR
     LPQLSETMRN LSMELTKAGV LEEMRDEMFL PVEDDEELMD LADEDEEVQE ILTKYNVIPA
     PSEKAADAAT HREQSLKQAL PSLSNGIAKD STEIDEEQLL DIRDKLDALK S
 
 
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