ID   VPS25_DANRE             Reviewed;         174 AA.
AC   Q6NWF4;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2005, sequence version 2.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Vacuolar protein-sorting-associated protein 25;
DE   AltName: Full=ESCRT-II complex subunit VPS25;
GN   Name=vps25;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the ESCRT-II complex (endosomal sorting complex
CC       required for transport II), which is required for multivesicular body
CC       (MVB) formation and sorting of endosomal cargo proteins into MVBs. The
CC       MVB pathway mediates delivery of transmembrane proteins into the lumen
CC       of the lysosome for degradation. The ESCRT-II complex is probably
CC       involved in the recruitment of the ESCRT-III complex (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the endosomal sorting complex required for
CC       transport II (ESCRT-II), composed of SNF8, VPS36 and 2 copies of VPS25.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the VPS25 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH67612.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC067612; AAH67612.1; ALT_INIT; mRNA.
DR   AlphaFoldDB; Q6NWF4; -.
DR   SMR; Q6NWF4; -.
DR   STRING; 7955.ENSDARP00000126886; -.
DR   PaxDb; Q6NWF4; -.
DR   ZFIN; ZDB-GENE-050506-30; vps25.
DR   eggNOG; KOG4068; Eukaryota.
DR   InParanoid; Q6NWF4; -.
DR   PhylomeDB; Q6NWF4; -.
DR   Reactome; R-DRE-917729; Endosomal Sorting Complex Required For Transport (ESCRT).
DR   PRO; PR:Q6NWF4; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0000814; C:ESCRT II complex; IBA:GO_Central.
DR   GO; GO:0042803; F:protein homodimerization activity; IBA:GO_Central.
DR   GO; GO:0005198; F:structural molecule activity; IBA:GO_Central.
DR   GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR   GO; GO:0043328; P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.10.570; -; 1.
DR   InterPro; IPR008570; ESCRT-II_cplx_Vps25-sub.
DR   InterPro; IPR014041; ESCRT-II_cplx_Vps25-sub_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR13149; PTHR13149; 1.
DR   Pfam; PF05871; ESCRT-II; 1.
DR   SUPFAM; SSF46785; SSF46785; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..174
FT                   /note="Vacuolar protein-sorting-associated protein 25"
FT                   /id="PRO_0000215219"
SQ   SEQUENCE   174 AA;  20706 MW;  0CFF947767027A35 CRC64;
     MSFEWPWQYN FPPFFTLQPN VDTRQKQLAA WCSLVLSYCR HRKLYTLDVL EAQESPVFNN
     KKIERKLSVE AIQVVFEELR KKGNLEWLDK NKSRCLIMWR RPEEWGKLIY QWVSKNGMVN
     SVFTLYELAN GDDTEKEEFH GLEDWMLLRS LQALQTDGKA EIITMDDGKG VKFF