VPS25_XENLA
ID VPS25_XENLA Reviewed; 174 AA.
AC Q6AX45;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Vacuolar protein-sorting-associated protein 25;
DE AltName: Full=ESCRT-II complex subunit VPS25;
GN Name=vps25;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the ESCRT-II complex (endosomal sorting complex
CC required for transport II), which is required for multivesicular body
CC (MVB) formation and sorting of endosomal cargo proteins into MVBs. The
CC MVB pathway mediates delivery of transmembrane proteins into the lumen
CC of the lysosome for degradation. The ESCRT-II complex is probably
CC involved in the recruitment of the ESCRT-III complex (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of the endosomal sorting complex required for
CC transport II (ESCRT-II), composed of SNF8, VPS36 and 2 copies of VPS25.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the VPS25 family. {ECO:0000305}.
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DR EMBL; BC079766; AAH79766.1; -; mRNA.
DR RefSeq; NP_001087424.1; NM_001093955.1.
DR AlphaFoldDB; Q6AX45; -.
DR SMR; Q6AX45; -.
DR MaxQB; Q6AX45; -.
DR DNASU; 447248; -.
DR GeneID; 447248; -.
DR KEGG; xla:447248; -.
DR CTD; 447248; -.
DR Xenbase; XB-GENE-976405; vps25.L.
DR OMA; SQEFHGM; -.
DR OrthoDB; 1094121at2759; -.
DR Proteomes; UP000186698; Chromosome 9_10L.
DR Bgee; 447248; Expressed in zone of skin and 19 other tissues.
DR GO; GO:0000814; C:ESCRT II complex; IEA:InterPro.
DR GO; GO:0071985; P:multivesicular body sorting pathway; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.10.570; -; 1.
DR InterPro; IPR008570; ESCRT-II_cplx_Vps25-sub.
DR InterPro; IPR014041; ESCRT-II_cplx_Vps25-sub_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR13149; PTHR13149; 1.
DR Pfam; PF05871; ESCRT-II; 1.
DR SUPFAM; SSF46785; SSF46785; 2.
PE 2: Evidence at transcript level;
KW Cytoplasm; Protein transport; Reference proteome; Transport.
FT CHAIN 1..174
FT /note="Vacuolar protein-sorting-associated protein 25"
FT /id="PRO_0000215220"
SQ SEQUENCE 174 AA; 20733 MW; 11D02DB20529293C CRC64;
MGFEWPWQYN FPPFFTLQPN VDTRQKQLSA WSSLVLSYCR QNKLYTMNLM EIQESPLFNN
KKIQRKLSLE SVQVVLEELR KKGNLEWIDK NKSRFLIMWR RPDEWGKVIY QWVSKNGMTN
SVFTLYELIS GDDTEGEEFH GLDEAMLLRS LEALQQEHKA EIITLNESRG VKFF