ID   VPS26_CAEEL             Reviewed;         356 AA.
AC   O01258;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   06-JUN-2002, sequence version 2.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=Vacuolar protein sorting-associated protein 26;
DE   AltName: Full=VPS26 protein homolog;
GN   Name=vps-26; ORFNames=T20D3.7;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: May play a role in vesicular protein sorting, similar to the
CC       yeast retromer proteins. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the VPS26 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA92489.2; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Z68220; CAA92489.2; ALT_INIT; Genomic_DNA.
DR   PIR; T25029; T25029.
DR   RefSeq; NP_001129871.1; NM_001136399.1.
DR   RefSeq; NP_501644.1; NM_069243.3.
DR   AlphaFoldDB; O01258; -.
DR   SMR; O01258; -.
DR   BioGRID; 42870; 2.
DR   STRING; 6239.T20D3.7c; -.
DR   EPD; O01258; -.
DR   PaxDb; O01258; -.
DR   EnsemblMetazoa; T20D3.7a.1; T20D3.7a.1; WBGene00006931.
DR   GeneID; 177764; -.
DR   KEGG; cel:CELE_T20D3.7; -.
DR   UCSC; T20D3.7; c. elegans.
DR   CTD; 177764; -.
DR   WormBase; T20D3.7a; CE28684; WBGene00006931; vps-26.
DR   eggNOG; KOG3063; Eukaryota.
DR   GeneTree; ENSGT00950000183064; -.
DR   HOGENOM; CLU_031077_2_0_1; -.
DR   InParanoid; O01258; -.
DR   PhylomeDB; O01258; -.
DR   Reactome; R-CEL-3238698; WNT ligand biogenesis and trafficking.
DR   PRO; PR:O01258; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00006931; Expressed in germ line (C elegans) and 4 other tissues.
DR   ExpressionAtlas; O01258; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0005768; C:endosome; IBA:GO_Central.
DR   GO; GO:0030904; C:retromer complex; IBA:GO_Central.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:0042147; P:retrograde transport, endosome to Golgi; IBA:GO_Central.
DR   Gene3D; 2.60.40.640; -; 2.
DR   InterPro; IPR014752; Arrestin-like_C.
DR   InterPro; IPR028934; Vps26-related.
DR   PANTHER; PTHR12233; PTHR12233; 1.
DR   Pfam; PF03643; Vps26; 1.
PE   3: Inferred from homology;
KW   Protein transport; Reference proteome; Transport.
FT   CHAIN           1..356
FT                   /note="Vacuolar protein sorting-associated protein 26"
FT                   /id="PRO_0000073010"
FT   REGION          301..356
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        301..316
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        340..356
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   356 AA;  40894 MW;  085A6A3B42C84D29 CRC64;
     MAMLFGFGQS AEIQIRLSNE DTRKIVKARG DDGNMHDHFL YYDGESVTGT VHVNLKKANH
     KFEHQGIRIE FIGQIEVYYD RGNQQDFISL TRELARPGDL TQNAQFPFEF NNVEKPFETY
     MGTNVKLRYF LRVTVIRRLT DLTKELDLVV HALSSYPDND KSIKMEVGIE DCLHIEFEYN
     KNKYHLQDVI VGKIYFLLVR IKIKYMEIAI LKTEVVGSGP NTFKESETVA KFEIMDGAPV
     RGESIPIRLF LAGYDLAPSM RDVGKKFSVK YFLNLVLVDE EDRRYFKQQE VTLWRKADKV
     MRRPGTEDDE EEKQTTSIPG TQKFTAPAPV EHPKPESPRS DPKSGSTSPD DNSDSS