ID   VPS26_DICDI             Reviewed;         349 AA.
AC   Q55CA0; Q23920;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Vacuolar protein sorting-associated protein 26;
GN   Name=vps26; Synonyms=pepA, rcdQ, veg152; ORFNames=DDB_G0269168;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AX4;
RX   PubMed=8643615; DOI=10.1073/pnas.93.11.5562;
RA   Kuspa A., Loomis W.F.;
RT   "Ordered yeast artificial chromosome clones representing the Dictyostelium
RT   discoideum genome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 93:5562-5566(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Plays a role in vesicular protein sorting. Component of the
CC       membrane-associated retromer complex which is essential in endosome-to-
CC       Golgi retrograde transport. The vps29-vps26-vps35 subcomplex may be
CC       involved in cargo selection. {ECO:0000250}.
CC   -!- SUBUNIT: Component of a retromer subcomplex consisting of vps29, vps26
CC       and vps35. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the VPS26 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U61985; AAB03668.1; -; mRNA.
DR   EMBL; AAFI02000005; EAL71934.1; -; Genomic_DNA.
DR   RefSeq; XP_646581.1; XM_641489.1.
DR   AlphaFoldDB; Q55CA0; -.
DR   SMR; Q55CA0; -.
DR   STRING; 44689.DDB0191205; -.
DR   PaxDb; Q55CA0; -.
DR   EnsemblProtists; EAL71934; EAL71934; DDB_G0269168.
DR   GeneID; 8617551; -.
DR   KEGG; ddi:DDB_G0269168; -.
DR   dictyBase; DDB_G0269168; vps26.
DR   eggNOG; KOG3063; Eukaryota.
DR   HOGENOM; CLU_031077_0_0_1; -.
DR   InParanoid; Q55CA0; -.
DR   OMA; LWVHSYR; -.
DR   PhylomeDB; Q55CA0; -.
DR   Reactome; R-DDI-3238698; WNT ligand biogenesis and trafficking.
DR   PRO; PR:Q55CA0; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0005768; C:endosome; IBA:GO_Central.
DR   GO; GO:0140220; C:pathogen-containing vacuole; IDA:dictyBase.
DR   GO; GO:0030904; C:retromer complex; ISS:dictyBase.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:0045053; P:protein retention in Golgi apparatus; ISS:dictyBase.
DR   GO; GO:0042147; P:retrograde transport, endosome to Golgi; ISS:dictyBase.
DR   Gene3D; 2.60.40.640; -; 2.
DR   InterPro; IPR014752; Arrestin-like_C.
DR   InterPro; IPR028934; Vps26-related.
DR   PANTHER; PTHR12233; PTHR12233; 1.
DR   Pfam; PF03643; Vps26; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..349
FT                   /note="Vacuolar protein sorting-associated protein 26"
FT                   /id="PRO_0000328099"
FT   REGION          299..349
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        304..341
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        195..196
FT                   /note="KI -> NF (in Ref. 1; AAB03668)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   349 AA;  40257 MW;  4E9685EA66CEE42A CRC64;
     MNFFSNNFGT PCNVEFELDN CQNRKTIEVT QDKGKTEKLF VFIGNEPVSG KVSINIKEKT
     KKIEHTGIRV EFVGQIELFY DRGNHYEFTS LVRELAPAGE LTENKTFSYD FSNVEKQYES
     YNGTNVRLRY FVRLTIGRSF ASNIVKEYDI WVINFVKPPE SNSNIKMEVG IEDCLHIEFE
     YNKSKYHLKD VIIGKIYFLL VRIKIKYMEI ALIKRESTGS GPNVFNESET LTKFEIMDGA
     PVRGESIPVR LFLSVFDLTP TYRSVHNKFS VKYFLNLALV DEDDKKYFKQ QEITLWRRGV
     TKPGLPGSTN NNNNNNTSNT NNTNTPQQKV TESQNEVPEP ENNSSDESD