ID   VPS26_PLAF7             Reviewed;         297 AA.
AC   Q8I4T1; A0A144A4V4;
DT   25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Vacuolar protein sorting-associated protein 26 {ECO:0000303|PubMed:29654975};
GN   Name=VPS26 {ECO:0000303|PubMed:29654975}; ORFNames=PF3D7_1250300, PFL2415w;
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3D7;
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2]
RP   IDENTIFICATION IN THE RETROMER COMPLEX, AND INTERACTION WITH SORTLR.
RX   PubMed=29654975; DOI=10.1016/j.bbapap.2018.04.005;
RA   Iqbal M.S., Siddiqui A.A., Banerjee C., Nag S., Mazumder S., De R.,
RA   Saha S.J., Karri S.K., Bandyopadhyay U.;
RT   "Detection of retromer assembly in Plasmodium falciparum by immunosensing
RT   coupled to Surface Plasmon Resonance.";
RL   Biochim. Biophys. Acta 1866:722-730(2018).
RN   [3]
RP   INTERACTION WITH RAB7.
RX   PubMed=32512169; DOI=10.1016/j.bbagen.2020.129656;
RA   Siddiqui A.A., Saha D., Iqbal M.S., Saha S.J., Sarkar S., Banerjee C.,
RA   Nag S., Mazumder S., De R., Pramanik S., Debsharma S., Bandyopadhyay U.;
RT   "Rab7 of Plasmodium falciparum is involved in its retromer complex assembly
RT   near the digestive vacuole.";
RL   Biochim. Biophys. Acta 1864:129656-129656(2020).
CC   -!- FUNCTION: Plays a role in vesicular protein sorting (By similarity).
CC       Component of the membrane-associated retromer complex which is
CC       essential in endosome-to-Golgi retrograde transport (By similarity).
CC       {ECO:0000250|UniProtKB:Q10243}.
CC   -!- SUBUNIT: Component of the retromer complex, composed of VPS26, VPS29
CC       and VPS35 (PubMed:29654975). As part of the retromer complex, interacts
CC       with the sorting receptor SORTLR/sortilin (PubMed:29654975). Interacts
CC       with GTPase RAB7 (PubMed:32512169). {ECO:0000269|PubMed:29654975,
CC       ECO:0000269|PubMed:32512169}.
CC   -!- SIMILARITY: Belongs to the VPS26 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LN999947; CZT99658.1; -; Genomic_DNA.
DR   RefSeq; XP_001350887.1; XM_001350851.1.
DR   AlphaFoldDB; Q8I4T1; -.
DR   SMR; Q8I4T1; -.
DR   STRING; 5833.PFL2415w; -.
DR   PRIDE; Q8I4T1; -.
DR   EnsemblProtists; CZT99658; CZT99658; PF3D7_1250300.
DR   GeneID; 811535; -.
DR   KEGG; pfa:PF3D7_1250300; -.
DR   VEuPathDB; PlasmoDB:PF3D7_1250300; -.
DR   HOGENOM; CLU_031077_2_0_1; -.
DR   InParanoid; Q8I4T1; -.
DR   OMA; LWVHSYR; -.
DR   PhylomeDB; Q8I4T1; -.
DR   Proteomes; UP000001450; Chromosome 12.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0005768; C:endosome; IBA:GO_Central.
DR   GO; GO:0030904; C:retromer complex; IDA:UniProtKB.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:0042147; P:retrograde transport, endosome to Golgi; IBA:GO_Central.
DR   Gene3D; 2.60.40.640; -; 2.
DR   InterPro; IPR014752; Arrestin-like_C.
DR   InterPro; IPR028934; Vps26-related.
DR   PANTHER; PTHR12233; PTHR12233; 1.
DR   Pfam; PF03643; Vps26; 1.
PE   1: Evidence at protein level;
KW   Protein transport; Reference proteome; Transport.
FT   CHAIN           1..297
FT                   /note="Vacuolar protein sorting-associated protein 26"
FT                   /id="PRO_0000073012"
SQ   SEQUENCE   297 AA;  34509 MW;  2BC74F6A9919C6D5 CRC64;
     MLSTIFGSVC SIDLKIDADD NKKFAFLRKD KKGEKCPIFS DGEDINGTAT ISLKPGKKFE
     HYGIKLELIG QINILNDKAN SYDFFSISKD LEPPGFLVES KQFKWKFSAV DKQHESYFGT
     NVQLRYFVRL NIIKGYSGNI QKEIDFIVQN LCIPPEINNT IKMEVGIEDC LHIEFEYDKS
     KYHLKDVVVG KVYFLLVRIK IKHMELDIIK METSGVGKNY TTETVTLSKF EIMDGSPIKS
     ECIPVRLYLS GFDLTPTYKN IQNKFSVKYY INLIIVDEEE RRYFKKQEIF LWRKKMG