VPS26_SCHPO
ID VPS26_SCHPO Reviewed; 298 AA.
AC Q10243;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Vacuolar protein sorting-associated protein 26;
GN Name=vps26; Synonyms=pep8; ORFNames=SPAC4G9.13c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION, AND IDENTIFICATION IN THE VPS29-VPS26-VPS35 RETROMER SUBCOMPLEX.
RX PubMed=16622069; DOI=10.1099/mic.0.28627-0;
RA Iwaki T., Hosomi A., Tokudomi S., Kusunoki Y., Fujita Y., Giga-Hama Y.,
RA Tanaka N., Takegawa K.;
RT "Vacuolar protein sorting receptor in Schizosaccharomyces pombe.";
RL Microbiology 152:1523-1532(2006).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Plays a role in vesicular protein sorting. Required for the
CC endosome-to-Golgi retrieval of the vacuolar protein sorting receptor
CC pep1/vps10. Component of the membrane-associated retromer complex which
CC is essential in endosome-to-Golgi retrograde transport. The vps29-
CC vps26-vps35 subcomplex may be involved in cargo selection.
CC {ECO:0000269|PubMed:16622069}.
CC -!- SUBUNIT: Component of the retromer complex which consists of vps29,
CC vps6, vps35, vps5 and vps17 (By similarity). Component of a retromer
CC subcomplex consisting of vps29, vps26 and vps35. {ECO:0000250,
CC ECO:0000269|PubMed:16622069}.
CC -!- SIMILARITY: Belongs to the VPS26 family. {ECO:0000305}.
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DR EMBL; CU329670; CAA93563.1; -; Genomic_DNA.
DR PIR; T38872; T38872.
DR RefSeq; NP_593695.1; NM_001019127.2.
DR AlphaFoldDB; Q10243; -.
DR SMR; Q10243; -.
DR BioGRID; 279817; 5.
DR STRING; 4896.SPAC4G9.13c.1; -.
DR MaxQB; Q10243; -.
DR PaxDb; Q10243; -.
DR PRIDE; Q10243; -.
DR EnsemblFungi; SPAC4G9.13c.1; SPAC4G9.13c.1:pep; SPAC4G9.13c.
DR GeneID; 2543395; -.
DR KEGG; spo:SPAC4G9.13c; -.
DR PomBase; SPAC4G9.13c; vps26.
DR VEuPathDB; FungiDB:SPAC4G9.13c; -.
DR eggNOG; KOG3063; Eukaryota.
DR HOGENOM; CLU_031077_2_0_1; -.
DR InParanoid; Q10243; -.
DR OMA; LWVHSYR; -.
DR PhylomeDB; Q10243; -.
DR Reactome; R-SPO-3238698; WNT ligand biogenesis and trafficking.
DR PRO; PR:Q10243; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005768; C:endosome; IMP:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0030904; C:retromer complex; IMP:PomBase.
DR GO; GO:0006886; P:intracellular protein transport; IMP:PomBase.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IMP:PomBase.
DR Gene3D; 2.60.40.640; -; 2.
DR InterPro; IPR014752; Arrestin-like_C.
DR InterPro; IPR028934; Vps26-related.
DR PANTHER; PTHR12233; PTHR12233; 1.
DR Pfam; PF03643; Vps26; 1.
PE 3: Inferred from homology;
KW Protein transport; Reference proteome; Transport.
FT CHAIN 1..298
FT /note="Vacuolar protein sorting-associated protein 26"
FT /id="PRO_0000073014"
SQ SEQUENCE 298 AA; 35780 MW; DDEEA150F25B3E6D CRC64;
MDYFFKSPID VDLHLDNEEE RTFVDYEFEQ GRKDKAPIYE SDETVKGTVM IRLKDGRKLD
HDGVKIEFIG QIENTYDKGN IHEFTRSVQE LASPGEMRHA QMFEFEFKHV DKPYESYIGK
NVKLRYICRV TVSRKMKDVI REKDLWVYRF ENEPETNSLI RMDVGIDECL HIEFEYSKNK
YHLKDVIIGK IYFILVRIKV QRMEVSIIRR ETIGTSPNQY SNSETITRFQ IMDGNPNRGE
TIPLRMFLNG YALTPTFRDV NKKFSVRYYL SLILVDEDQR RYFKQSEITL WRRRDEHE
