ID   VPS28_CAEBR             Reviewed;         209 AA.
AC   A8XWB7;
DT   15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Vacuolar protein sorting-associated protein 28 homolog {ECO:0000250|UniProtKB:Q9NA26};
DE   AltName: Full=ESCRT-I complex subunit VPS28 {ECO:0000250|UniProtKB:Q9NA26};
GN   Name=vps-28 {ECO:0000312|EMBL:CAP36936.1}; ORFNames=CBG19782;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1] {ECO:0000312|EMBL:CAP36936.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Component of the ESCRT-I complex, a regulator of vesicular
CC       trafficking process. {ECO:0000250|UniProtKB:Q9NA26}.
CC   -!- SUBUNIT: Component of the ESCRT-I complex (endosomal sorting complex
CC       required for transport I). {ECO:0000250|UniProtKB:Q9NA26}.
CC   -!- SUBCELLULAR LOCATION: Endosome {ECO:0000250|UniProtKB:Q02767}.
CC   -!- SIMILARITY: Belongs to the VPS28 family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00642, ECO:0000255|PROSITE-ProRule:PRU00645}.
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DR   EMBL; HE601474; CAP36936.1; -; Genomic_DNA.
DR   RefSeq; XP_002640715.1; XM_002640669.1.
DR   AlphaFoldDB; A8XWB7; -.
DR   SMR; A8XWB7; -.
DR   STRING; 6238.CBG19782; -.
DR   EnsemblMetazoa; CBG19782.1; CBG19782.1; WBGene00038947.
DR   GeneID; 8582710; -.
DR   KEGG; cbr:CBG_19782; -.
DR   CTD; 8582710; -.
DR   WormBase; CBG19782; CBP19690; WBGene00038947; Cbr-vps-28.
DR   eggNOG; KOG3284; Eukaryota.
DR   HOGENOM; CLU_076417_2_0_1; -.
DR   InParanoid; A8XWB7; -.
DR   OMA; CDEFPTV; -.
DR   OrthoDB; 1281819at2759; -.
DR   Proteomes; UP000008549; Chromosome I.
DR   GO; GO:0000813; C:ESCRT I complex; IBA:GO_Central.
DR   GO; GO:0044877; F:protein-containing complex binding; IBA:GO_Central.
DR   GO; GO:0043328; P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IBA:GO_Central.
DR   GO; GO:0032801; P:receptor catabolic process; IEA:EnsemblMetazoa.
DR   Gene3D; 1.20.120.1130; -; 1.
DR   Gene3D; 1.20.1440.200; -; 1.
DR   InterPro; IPR037202; ESCRT_assembly_dom.
DR   InterPro; IPR007143; Vps28.
DR   InterPro; IPR017899; VPS28_C.
DR   InterPro; IPR037206; VPS28_C_sf.
DR   InterPro; IPR017898; VPS28_N.
DR   InterPro; IPR038358; VPS28_N_sf.
DR   PANTHER; PTHR12937; PTHR12937; 1.
DR   Pfam; PF03997; VPS28; 1.
DR   PIRSF; PIRSF017535; VPS28; 1.
DR   SUPFAM; SSF140111; SSF140111; 1.
DR   SUPFAM; SSF140427; SSF140427; 1.
DR   PROSITE; PS51310; VPS28_C; 1.
DR   PROSITE; PS51313; VPS28_N; 1.
PE   3: Inferred from homology;
KW   Endosome; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..209
FT                   /note="Vacuolar protein sorting-associated protein 28
FT                   homolog"
FT                   /id="PRO_0000394401"
FT   DOMAIN          1..105
FT                   /note="VPS28 N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00645"
FT   DOMAIN          109..205
FT                   /note="VPS28 C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00642"
SQ   SEQUENCE   209 AA;  24268 MW;  5D685D78097D9851 CRC64;
     MSQNSNLMRE VRLFENHSER EQMENLSELF AVLNALEHLE KMFSRDHVTA DEYKTECFKL
     IDQYKVTMRL VHGATSIEEF AKKYRLHCPA AIERIREGRP ITVKDDQGNV LKHIASIVEQ
     FITFLDSLRL NTRAVDDLYP VLDDLYNAIN STSRVPIDAN VTTKVKKWHD RLSSMAATDE
     ISDDEARQMI FDTEGAYQSF QKALNEQKH