VPS28_CAEEL
ID VPS28_CAEEL Reviewed; 210 AA.
AC Q9NA26;
DT 21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Vacuolar protein sorting-associated protein 28 homolog;
DE AltName: Full=ESCRT-I complex subunit VPS28;
GN Name=vps-28; ORFNames=Y87G2A.10;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP IDENTIFICATION.
RX PubMed=15998324; DOI=10.1111/j.1600-0854.2005.00309.x;
RA Roudier N., Lefebvre C., Legouis R.;
RT "CeVPS-27 is an endosomal protein required for the molting and the
RT endocytic trafficking of the low-density lipoprotein receptor-related
RT protein 1 in Caenorhabditis elegans.";
RL Traffic 6:695-705(2005).
RN [3]
RP FUNCTION, SUBUNIT, AND TISSUE SPECIFICITY.
RX PubMed=17895996; DOI=10.1371/journal.pone.0000956;
RA Audhya A., McLeod I.X., Yates J.R., Oegema K.;
RT "MVB-12, a fourth subunit of metazoan ESCRT-I, functions in receptor
RT downregulation.";
RL PLoS ONE 2:E956-E956(2007).
RN [4]
RP FUNCTION.
RX PubMed=18472420; DOI=10.1016/j.cub.2008.04.043;
RA Cheng H., Govindan J.A., Greenstein D.;
RT "Regulated trafficking of the MSP/Eph receptor during oocyte meiotic
RT maturation in C. elegans.";
RL Curr. Biol. 18:705-714(2008).
CC -!- FUNCTION: Component of the ESCRT-I complex, a regulator of vesicular
CC trafficking process. {ECO:0000269|PubMed:17895996,
CC ECO:0000269|PubMed:18472420}.
CC -!- SUBUNIT: Component of the ESCRT-I complex (endosomal sorting complex
CC required for transport I). {ECO:0000269|PubMed:17895996}.
CC -!- SUBCELLULAR LOCATION: Endosome {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in embryos.
CC {ECO:0000269|PubMed:17895996}.
CC -!- SIMILARITY: Belongs to the VPS28 family. {ECO:0000255|PROSITE-
CC ProRule:PRU00642, ECO:0000255|PROSITE-ProRule:PRU00645}.
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DR EMBL; AL110500; CAB54493.1; -; Genomic_DNA.
DR PIR; T27471; T27471.
DR RefSeq; NP_493382.1; NM_060981.5.
DR AlphaFoldDB; Q9NA26; -.
DR SMR; Q9NA26; -.
DR BioGRID; 38623; 16.
DR IntAct; Q9NA26; 1.
DR STRING; 6239.Y87G2A.10a; -.
DR EPD; Q9NA26; -.
DR PaxDb; Q9NA26; -.
DR PeptideAtlas; Q9NA26; -.
DR EnsemblMetazoa; Y87G2A.10a.1; Y87G2A.10a.1; WBGene00013598.
DR GeneID; 173229; -.
DR KEGG; cel:CELE_Y87G2A.10; -.
DR CTD; 173229; -.
DR WormBase; Y87G2A.10a; CE23139; WBGene00013598; vps-28.
DR eggNOG; KOG3284; Eukaryota.
DR GeneTree; ENSGT00390000007486; -.
DR HOGENOM; CLU_076417_2_0_1; -.
DR InParanoid; Q9NA26; -.
DR OMA; CDEFPTV; -.
DR OrthoDB; 1281819at2759; -.
DR PhylomeDB; Q9NA26; -.
DR Reactome; R-CEL-917729; Endosomal Sorting Complex Required For Transport (ESCRT).
DR PRO; PR:Q9NA26; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00013598; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0000813; C:ESCRT I complex; IPI:WormBase.
DR GO; GO:0044877; F:protein-containing complex binding; IBA:GO_Central.
DR GO; GO:0043328; P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IBA:GO_Central.
DR GO; GO:0032801; P:receptor catabolic process; IMP:WormBase.
DR Gene3D; 1.20.120.1130; -; 1.
DR Gene3D; 1.20.1440.200; -; 1.
DR InterPro; IPR037202; ESCRT_assembly_dom.
DR InterPro; IPR007143; Vps28.
DR InterPro; IPR017899; VPS28_C.
DR InterPro; IPR037206; VPS28_C_sf.
DR InterPro; IPR017898; VPS28_N.
DR InterPro; IPR038358; VPS28_N_sf.
DR PANTHER; PTHR12937; PTHR12937; 1.
DR Pfam; PF03997; VPS28; 1.
DR PIRSF; PIRSF017535; VPS28; 1.
DR SUPFAM; SSF140111; SSF140111; 1.
DR SUPFAM; SSF140427; SSF140427; 1.
DR PROSITE; PS51310; VPS28_C; 1.
DR PROSITE; PS51313; VPS28_N; 1.
PE 1: Evidence at protein level;
KW Endosome; Protein transport; Reference proteome; Transport.
FT CHAIN 1..210
FT /note="Vacuolar protein sorting-associated protein 28
FT homolog"
FT /id="PRO_0000120953"
FT DOMAIN 1..106
FT /note="VPS28 N-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00645"
FT DOMAIN 110..206
FT /note="VPS28 C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00642"
SQ SEQUENCE 210 AA; 24221 MW; 1BF18A8924620FD6 CRC64;
MSSQNANLMR EVRLFENHSE REQMENLSEL FAVLNALEHL EKMFSRDHVS ADEYKSECFK
LIDQYKVTMR LVHGATSIED FAKKYRLHCP AAIERIREGR PITVKDDQGN VLKHIASIVE
QFITFLDALR LNTRAVDDLY PGLDDLYNAI NTTSRVPIDA IVTTKVKKWH DRLSSMAASD
EISDEDARQM IFDVESAYQA FNKALNELKH
