ID   VPS29_CHICK             Reviewed;         186 AA.
AC   Q5ZIL2;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Vacuolar protein sorting-associated protein 29;
DE   AltName: Full=Vesicle protein sorting 29;
GN   Name=VPS29; ORFNames=RCJMB04_25e21;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Acts as component of the retromer cargo-selective complex
CC       (CSC). The CSC is believed to be the core functional component of
CC       retromer or respective retromer complex variants acting to prevent
CC       missorting of selected transmembrane cargo proteins into the lysosomal
CC       degradation pathway. Retromer mediates retrograde transport of cargo
CC       proteins from endosomes to the trans-Golgi network (TGN) (By
CC       similarity). Acts also as component of the retriever complex. The
CC       retriever complex is an heterotrimeric complex related to retromer
CC       cargo-selective complex (CSC) and essential for retromer-independent
CC       retrieval and recycling of numerous cargos such as integrins. In the
CC       endosomes, retriever complex drives the retrieval and recycling of
CC       NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo
CC       essential for the homeostatic maintenance of numerous cell surface
CC       proteins associated with processes that include cell migration, cell
CC       adhesion, nutrient supply and cell signaling (By similarity).
CC       {ECO:0000250|UniProtKB:Q9UBQ0}.
CC   -!- SUBUNIT: Component of the heterotrimeric retromer cargo-selective
CC       complex (CSC) which is believed to associate with variable sorting
CC       nexins to form functionally distinct retromer complex variants (By
CC       similarity). Component of the heterotrimeric retriever complex (By
CC       similarity). {ECO:0000250|UniProtKB:Q9UBQ0}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein.
CC       Endosome membrane {ECO:0000250|UniProtKB:Q9QZ88}; Peripheral membrane
CC       protein {ECO:0000250|UniProtKB:Q9QZ88}.
CC   -!- SIMILARITY: Belongs to the VPS29 family. {ECO:0000305}.
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DR   EMBL; AJ720772; CAG32431.1; -; mRNA.
DR   RefSeq; NP_001007838.1; NM_001007837.1.
DR   AlphaFoldDB; Q5ZIL2; -.
DR   SMR; Q5ZIL2; -.
DR   STRING; 9031.ENSGALP00000038322; -.
DR   PaxDb; Q5ZIL2; -.
DR   GeneID; 416867; -.
DR   KEGG; gga:416867; -.
DR   CTD; 51699; -.
DR   VEuPathDB; HostDB:geneid_416867; -.
DR   eggNOG; KOG3325; Eukaryota.
DR   InParanoid; Q5ZIL2; -.
DR   OrthoDB; 1233814at2759; -.
DR   PhylomeDB; Q5ZIL2; -.
DR   PRO; PR:Q5ZIL2; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0005768; C:endosome; IBA:GO_Central.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030904; C:retromer complex; ISS:UniProtKB.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0032456; P:endocytic recycling; ISS:UniProtKB.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:0042147; P:retrograde transport, endosome to Golgi; IBA:GO_Central.
DR   CDD; cd07394; MPP_Vps29; 1.
DR   Gene3D; 3.60.21.10; -; 1.
DR   InterPro; IPR024654; Calcineurin-like_PHP_lpxH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   InterPro; IPR000979; Phosphodiesterase_MJ0936/Vps29.
DR   InterPro; IPR028661; Vps29.
DR   PANTHER; PTHR11124; PTHR11124; 1.
DR   PANTHER; PTHR11124:SF12; PTHR11124:SF12; 1.
DR   Pfam; PF12850; Metallophos_2; 1.
DR   SUPFAM; SSF56300; SSF56300; 1.
DR   TIGRFAMs; TIGR00040; yfcE; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Endosome; Membrane; Metal-binding; Protein transport;
KW   Reference proteome; Transport; Zinc.
FT   CHAIN           1..186
FT                   /note="Vacuolar protein sorting-associated protein 29"
FT                   /id="PRO_0000339650"
SQ   SEQUENCE   186 AA;  20939 MW;  B8FFAFD509CD56D6 CRC64;
     MAGHRLVLVL GDLHIPHRCN SLPAKFKKLL VPGKIQHILC TGNLCTKDTY DYLKTLAGDV
     HVVRGDFDEN LNYPEQKVVT VGQFKIGLIH GHQVIPWGDM ASLALLQRQF DVDILISGHT
     HKFEAFEHEN KFYINPGSAT GAYHALENNI IPSFVLMDIQ ASTVVTYVYQ LIGDDVKVER
     IEYKKS