VPS29_SCHPO
ID VPS29_SCHPO Reviewed; 187 AA.
AC Q9UTI5;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 112.
DE RecName: Full=Vacuolar protein sorting-associated protein 29;
GN Name=vps29; ORFNames=SPAC15E1.06;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION, AND IDENTIFICATION IN THE VPS29-VPS26-VPS35 RETROMER SUBCOMPLEX.
RX PubMed=16622069; DOI=10.1099/mic.0.28627-0;
RA Iwaki T., Hosomi A., Tokudomi S., Kusunoki Y., Fujita Y., Giga-Hama Y.,
RA Tanaka N., Takegawa K.;
RT "Vacuolar protein sorting receptor in Schizosaccharomyces pombe.";
RL Microbiology 152:1523-1532(2006).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Plays a role in vesicular protein sorting. Required for the
CC endosome-to-Golgi retrieval of the vacuolar protein sorting receptor
CC pep1/vps10. Component of the membrane-associated retromer complex which
CC is essential in endosome-to-Golgi retrograde transport. The vps29-
CC vps26-vps35 subcomplex may be involved in cargo selection.
CC {ECO:0000269|PubMed:16622069}.
CC -!- SUBUNIT: Component of the retromer complex which consists of vps29,
CC vps6, vps35, vps5 and vps17 (By similarity). Component of a retromer
CC subcomplex consisting of vps29, vps26 and vps35. {ECO:0000250,
CC ECO:0000269|PubMed:16622069}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the VPS29 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CU329670; CAB52425.1; -; Genomic_DNA.
DR PIR; T37721; T37721.
DR RefSeq; NP_594307.1; NM_001019730.2.
DR AlphaFoldDB; Q9UTI5; -.
DR SMR; Q9UTI5; -.
DR BioGRID; 279250; 5.
DR STRING; 4896.SPAC15E1.06.1; -.
DR MaxQB; Q9UTI5; -.
DR PaxDb; Q9UTI5; -.
DR EnsemblFungi; SPAC15E1.06.1; SPAC15E1.06.1:pep; SPAC15E1.06.
DR GeneID; 2542802; -.
DR KEGG; spo:SPAC15E1.06; -.
DR PomBase; SPAC15E1.06; vps29.
DR VEuPathDB; FungiDB:SPAC15E1.06; -.
DR eggNOG; KOG3325; Eukaryota.
DR HOGENOM; CLU_063749_0_1_1; -.
DR InParanoid; Q9UTI5; -.
DR OMA; IHGHQCI; -.
DR PhylomeDB; Q9UTI5; -.
DR Reactome; R-SPO-3238698; WNT ligand biogenesis and trafficking.
DR PRO; PR:Q9UTI5; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005768; C:endosome; IMP:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0030904; C:retromer complex; IMP:PomBase.
DR GO; GO:0006886; P:intracellular protein transport; IMP:PomBase.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IMP:PomBase.
DR CDD; cd07394; MPP_Vps29; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR InterPro; IPR024654; Calcineurin-like_PHP_lpxH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR000979; Phosphodiesterase_MJ0936/Vps29.
DR InterPro; IPR028661; Vps29.
DR PANTHER; PTHR11124; PTHR11124; 1.
DR PANTHER; PTHR11124:SF12; PTHR11124:SF12; 1.
DR Pfam; PF12850; Metallophos_2; 1.
DR SUPFAM; SSF56300; SSF56300; 1.
DR TIGRFAMs; TIGR00040; yfcE; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT CHAIN 1..187
FT /note="Vacuolar protein sorting-associated protein 29"
FT /id="PRO_0000339646"
SQ SEQUENCE 187 AA; 20523 MW; 545A3FC0E6715DD6 CRC64;
MLVLVIGDFH IPDRAPKLSE KFRQLLIPGK ISQIICLGNL TSTSVYEYLK HVCSDLKLVK
GAFDISSKAP IAGKITLGSF KIGYTNGHLV VPQDSPEALS ILAREMDADI LLFGGTHKFA
AYELDGCFFV NPGSATGAPN VSAVEDDEKI VPSFVLMDVQ GAVLILYVYR IFDGEVRVEK
MQYRKPE
