VPS33_SCHPO
ID VPS33_SCHPO Reviewed; 592 AA.
AC Q9P7V6; Q9Y7K3;
DT 23-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 112.
DE RecName: Full=Vacuolar protein sorting-associated protein 33;
GN Name=vps33; ORFNames=SPBC1703.15c, SPBC2A9.01c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP IDENTIFICATION, AND FUNCTION.
RX PubMed=12868054; DOI=10.1002/yea.1011;
RA Iwaki T., Osawa F., Onishi M., Koga T., Fujita Y., Hosomi A., Tanaka N.,
RA Fukui Y., Takegawa K.;
RT "Characterization of vps33+, a gene required for vacuolar biogenesis and
RT protein sorting in Schizosaccharomyces pombe.";
RL Yeast 20:845-855(2003).
CC -!- FUNCTION: Essential for vacuolar biogenesis, maturation and function.
CC Involved in the sorting of vacuolar proteins from the Golgi apparatus
CC and their targeting to the vacuole. {ECO:0000269|PubMed:12868054}.
CC -!- SIMILARITY: Belongs to the STXBP/unc-18/SEC1 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CU329671; CAB66459.1; -; Genomic_DNA.
DR PIR; T50328; T50328.
DR RefSeq; NP_596210.1; NM_001022129.2.
DR AlphaFoldDB; Q9P7V6; -.
DR SMR; Q9P7V6; -.
DR STRING; 4896.SPBC1703.15c.1; -.
DR iPTMnet; Q9P7V6; -.
DR MaxQB; Q9P7V6; -.
DR PaxDb; Q9P7V6; -.
DR PRIDE; Q9P7V6; -.
DR EnsemblFungi; SPBC1703.15c.1; SPBC1703.15c.1:pep; SPBC1703.15c.
DR GeneID; 2539880; -.
DR KEGG; spo:SPBC1703.15c; -.
DR PomBase; SPBC1703.15c; vps33.
DR VEuPathDB; FungiDB:SPBC1703.15c; -.
DR eggNOG; KOG1302; Eukaryota.
DR HOGENOM; CLU_016678_3_1_1; -.
DR InParanoid; Q9P7V6; -.
DR OMA; FHIFFVP; -.
DR PhylomeDB; Q9P7V6; -.
DR PRO; PR:Q9P7V6; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0033263; C:CORVET complex; ISO:PomBase.
DR GO; GO:0000324; C:fungal-type vacuole; IBA:GO_Central.
DR GO; GO:1902500; C:vacuolar HOPS complex; ISO:PomBase.
DR GO; GO:0005773; C:vacuole; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; ISO:PomBase.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0042144; P:vacuole fusion, non-autophagic; IMP:PomBase.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR Gene3D; 1.25.40.850; -; 1.
DR Gene3D; 3.40.50.1910; -; 1.
DR Gene3D; 3.40.50.2060; -; 1.
DR Gene3D; 3.90.830.10; -; 1.
DR InterPro; IPR043154; Sec-1-like_dom1.
DR InterPro; IPR043127; Sec-1-like_dom3a.
DR InterPro; IPR001619; Sec1-like.
DR InterPro; IPR027482; Sec1-like_dom2.
DR InterPro; IPR036045; Sec1-like_sf.
DR InterPro; IPR027121; VPS33.
DR InterPro; IPR043155; VPS33_dom3b.
DR PANTHER; PTHR11679; PTHR11679; 1.
DR PANTHER; PTHR11679:SF1; PTHR11679:SF1; 1.
DR Pfam; PF00995; Sec1; 1.
DR SUPFAM; SSF56815; SSF56815; 1.
PE 3: Inferred from homology;
KW Protein transport; Reference proteome; Transport.
FT CHAIN 1..592
FT /note="Vacuolar protein sorting-associated protein 33"
FT /id="PRO_0000206310"
SQ SEQUENCE 592 AA; 67600 MW; B3F9E1A09C3016BA CRC64;
MTTDVKEKAT FKLLDLIDSV TGKKSLLLER DLSGILGQIV TTNTLQEHGI PQVYWFNENI
PNDIEKKTIY LCRPTYENAK LVATHVRQFQ RDMLRIESTV IVLPTSNILF ETVLQEEGVF
GELLVTEWPL HAVPLDKDLL SLELGPEKLE ESLLQRSTDA LIDFERTHGR FPRVSGRGPY
AAKMLELLEK TYQEEATINF GKVEGEISAL YDSVLLVDRS LDRITPFLTQ LTYFGFLDEI
LGIQQMNVKL PSSLVNRNEA SNTGPMKKFS LSSSSSQITK EIRDINFNCI GPYLSKIARK
LSSDFEGRRQ AKTVNQIRDF VSKLGSLQSE HTSLNIHTGL AETLVQHTKN NYFQKLLQLQ
HLLVSHADSF TQFNLLDEII YAEAPVEEVF RVLCLASITT NGLRRKDIDH YRREITQTYG
YYHLLTFQAL IDAGLLRLRQ STNISLQKSL SYSTWLNTYP LVKDEVDEQN PEDIAYTYSG
YGPLSVHIAY DILKGRDNEE KILKLQNMPG TYVDKWTLDQ EKVMPKNLKT NVPGKRRVLV
FFIGGCTYTE LAAFRLLQEK EDLYEFTFMT TGMVTGSSLI RAFIPNIESL NE
