ID   VPS36_DANRE             Reviewed;         382 AA.
AC   Q7ZVK4;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Vacuolar protein-sorting-associated protein 36;
DE   AltName: Full=ESCRT-II complex subunit VPS36;
GN   Name=vps36; ORFNames=zgc:55965;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the ESCRT-II complex (endosomal sorting complex
CC       required for transport II), which is required for multivesicular body
CC       (MVB) formation and sorting of endosomal cargo proteins into MVBs. The
CC       MVB pathway mediates delivery of transmembrane proteins into the lumen
CC       of the lysosome for degradation. The ESCRT-II complex is probably
CC       involved in the recruitment of the ESCRT-III complex.
CC       {ECO:0000250|UniProtKB:Q86VN1}.
CC   -!- SUBUNIT: Component of the endosomal sorting complex required for
CC       transport II (ESCRT-II), composed of SNF8, VPS25 and VPS36.
CC       {ECO:0000250|UniProtKB:Q86VN1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the VPS36 family. {ECO:0000305}.
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DR   EMBL; BC045509; AAH45509.1; -; mRNA.
DR   RefSeq; NP_956271.1; NM_199977.1.
DR   AlphaFoldDB; Q7ZVK4; -.
DR   SMR; Q7ZVK4; -.
DR   STRING; 7955.ENSDARP00000074049; -.
DR   PaxDb; Q7ZVK4; -.
DR   GeneID; 335810; -.
DR   KEGG; dre:335810; -.
DR   CTD; 51028; -.
DR   ZFIN; ZDB-GENE-030131-7753; vps36.
DR   eggNOG; KOG2760; Eukaryota.
DR   InParanoid; Q7ZVK4; -.
DR   OrthoDB; 981902at2759; -.
DR   PhylomeDB; Q7ZVK4; -.
DR   Reactome; R-DRE-917729; Endosomal Sorting Complex Required For Transport (ESCRT).
DR   PRO; PR:Q7ZVK4; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005768; C:endosome; ISS:UniProtKB.
DR   GO; GO:0000814; C:ESCRT II complex; IBA:GO_Central.
DR   GO; GO:0031902; C:late endosome membrane; IBA:GO_Central.
DR   GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:InterPro.
DR   GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
DR   GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR   GO; GO:0043328; P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 2.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR021648; GLUE_dom.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR040608; Snf8/Vps36.
DR   InterPro; IPR037855; Vps36.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR13128; PTHR13128; 1.
DR   Pfam; PF04157; EAP30; 1.
DR   Pfam; PF11605; Vps36_ESCRT-II; 1.
DR   SUPFAM; SSF46785; SSF46785; 2.
DR   PROSITE; PS51495; GLUE; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Endosome; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..382
FT                   /note="Vacuolar protein-sorting-associated protein 36"
FT                   /id="PRO_0000215225"
FT   DOMAIN          1..88
FT                   /note="GLUE N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00828"
FT   DOMAIN          105..138
FT                   /note="GLUE C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00828"
FT   COILED          160..193
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   382 AA;  43281 MW;  69FDDCB91633FAAB CRC64;
     MDRFMWTNGL LEMNETLVIQ QRGVRLYDGE DKAKLDVGGV VLSTHRLLWR DQKNHECCIC
     IPLSQVIFFE EQAAGIGKSA KIVIHLHPAP ENKEPGPYQH SKYSYIKLSF KEHGQIEFYR
     RLTEEMTQKR WENTPVSQPI PTGTGPKAGR TRAVGIVGIE RKLEEKRKET DKNISEAFED
     LSKLMEKAKE MVELSRSIAN KIKDKQGDIT EDETIRFKSY LLSMGIANPV TRETHGSGTQ
     YHIQLAKQLG DMLQAPLEER GGMMALTEVY CLVNRARGME LLSPEDLVNA CKIFESLKLP
     LRLRVFDSGV MVVQLQSHSE EEMIASALDN VSDKGSLTAE EFAKLLGLSV LLAKERLLLA
     EKMGHLCRDD SVEGLRFYPN LF