VPS36_DICDI
ID VPS36_DICDI Reviewed; 611 AA.
AC Q54T18;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Vacuolar protein-sorting-associated protein 36;
DE AltName: Full=ESCRT-II complex subunit VPS36;
GN Name=vps36; ORFNames=DDB_G0282045;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Component of the ESCRT-II complex, which is required for
CC multivesicular body (MVB) formation and sorting of endosomal cargo
CC proteins into MVBs. The MVB pathway mediates delivery of transmembrane
CC proteins into the lumen of the lysosome for degradation (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the endosomal sorting required for transport
CC complex II (ESCRT-II). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endosome membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the VPS36 family. {ECO:0000305}.
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DR EMBL; AAFI02000044; EAL66444.1; -; Genomic_DNA.
DR RefSeq; XP_640433.1; XM_635341.1.
DR AlphaFoldDB; Q54T18; -.
DR SMR; Q54T18; -.
DR STRING; 44689.DDB0234028; -.
DR PaxDb; Q54T18; -.
DR EnsemblProtists; EAL66444; EAL66444; DDB_G0282045.
DR GeneID; 8623388; -.
DR KEGG; ddi:DDB_G0282045; -.
DR dictyBase; DDB_G0282045; vps36.
DR eggNOG; KOG2760; Eukaryota.
DR HOGENOM; CLU_447210_0_0_1; -.
DR InParanoid; Q54T18; -.
DR OMA; LYRACLL; -.
DR Reactome; R-DDI-917729; Endosomal Sorting Complex Required For Transport (ESCRT).
DR PRO; PR:Q54T18; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0000814; C:ESCRT II complex; ISS:dictyBase.
DR GO; GO:0031902; C:late endosome membrane; IBA:GO_Central.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
DR GO; GO:0006605; P:protein targeting; ISS:dictyBase.
DR GO; GO:0043328; P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 2.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR021648; GLUE_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR040608; Snf8/Vps36.
DR InterPro; IPR037855; Vps36.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR13128; PTHR13128; 2.
DR Pfam; PF04157; EAP30; 1.
DR Pfam; PF11605; Vps36_ESCRT-II; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS51495; GLUE; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Endosome; Membrane; Protein transport;
KW Reference proteome; Repeat; Transport.
FT CHAIN 1..611
FT /note="Vacuolar protein-sorting-associated protein 36"
FT /id="PRO_0000367438"
FT DOMAIN 7..94
FT /note="GLUE N-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00828"
FT DOMAIN 97..129
FT /note="GLUE C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00828"
FT REGION 119..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 213..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 280..346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 204..288
FT /evidence="ECO:0000255"
SQ SEQUENCE 611 AA; 70565 MW; 8F6A2C3B970D8227 CRC64;
METLFQKTRV INGEPELIQN ESIIYKVDNV SIYDGDQKTQ YSNGTVMLST HRVIWVNKDI
GLGLLHQLIL NIEALTTGLM GIGSSPKILI TLTKRSFRLS FHAGRRDDFL KLYRQSLLNK
PSQSPSPTSS TSQFINQPNN NNNNYNNNNS YQTPLQPPQY QQQQKEQQQQ YNSYNPYQQQ
SSQSPQQPQQ QYNSYNPYQS YVQQQQQQQQ QQQQQQQQQQ IPQYQQQTSP PPPNYYEHIQ
QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQH QQQQRQQSPS LYNSYHSTQQ
PLPPPSYLQH MQQQQQQSPS PSPQYQQTNS NSLPSQPPQP NYNLQNFINT PIISNNSNNN
NTNINGFTSN AGIGGIINQM NKKTLENDKL LSESFSDLNI LMEKAKDMVT LSEKLKVTLE
KKTGTSTSTE EEEEFRSFLL EMGIESPVTK KTAKSKYHDQ LSKQLSDWII TKNILKQHKG
SGNNEMITLS DLYCIFNRAR GIELISPDDL YRACLLFESL DLPLRLRKFD SGVIVVQSKD
ENDEQIAKQI LDIINENGPL SAFDLAKINS ISLHLAKDQL LVGVTSEKLG KLCRDETVEG
NILYHINIFV D
