ID   VPS36_XENLA             Reviewed;         388 AA.
AC   Q6DDF4;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Vacuolar protein-sorting-associated protein 36;
DE   AltName: Full=ESCRT-II complex subunit VPS36;
GN   Name=vps36;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the ESCRT-II complex (endosomal sorting complex
CC       required for transport II), which is required for multivesicular body
CC       (MVB) formation and sorting of endosomal cargo proteins into MVBs. The
CC       MVB pathway mediates delivery of transmembrane proteins into the lumen
CC       of the lysosome for degradation. The ESCRT-II complex is probably
CC       involved in the recruitment of the ESCRT-III complex.
CC       {ECO:0000250|UniProtKB:Q86VN1}.
CC   -!- SUBUNIT: Component of the endosomal sorting required for transport
CC       complex II (ESCRT-II), composed of SNF8, VPS25 and VPS36.
CC       {ECO:0000250|UniProtKB:Q86VN1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the VPS36 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC077615; AAH77615.1; -; mRNA.
DR   RefSeq; NP_001086892.1; NM_001093423.1.
DR   AlphaFoldDB; Q6DDF4; -.
DR   SMR; Q6DDF4; -.
DR   PRIDE; Q6DDF4; -.
DR   DNASU; 446727; -.
DR   GeneID; 446727; -.
DR   KEGG; xla:446727; -.
DR   CTD; 446727; -.
DR   Xenbase; XB-GENE-6255362; vps36.L.
DR   OrthoDB; 981902at2759; -.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 446727; Expressed in zone of skin and 19 other tissues.
DR   GO; GO:0005768; C:endosome; ISS:UniProtKB.
DR   GO; GO:0000814; C:ESCRT II complex; IEA:InterPro.
DR   GO; GO:0003730; F:mRNA 3'-UTR binding; IDA:UniProtKB.
DR   GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:InterPro.
DR   GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR   GO; GO:0032509; P:endosome transport via multivesicular body sorting pathway; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 2.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR021648; GLUE_dom.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR040608; Snf8/Vps36.
DR   InterPro; IPR037855; Vps36.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR13128; PTHR13128; 1.
DR   Pfam; PF04157; EAP30; 1.
DR   Pfam; PF11605; Vps36_ESCRT-II; 1.
DR   SUPFAM; SSF46785; SSF46785; 2.
DR   PROSITE; PS51495; GLUE; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Endosome; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..388
FT                   /note="Vacuolar protein-sorting-associated protein 36"
FT                   /id="PRO_0000215226"
FT   DOMAIN          1..88
FT                   /note="GLUE N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00828"
FT   DOMAIN          105..138
FT                   /note="GLUE C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00828"
FT   COILED          162..198
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   388 AA;  43918 MW;  315A1EC3222B89F7 CRC64;
     MDRFSWCTGL LDIDETLVIQ QRGVRLSDGE EKTKFDSGTL LLTTHRLIWR DQKNHDFCIA
     FPLSQIVFTE EQAGGIGKSA KIVVHLHPAT PNKEPGPYQT SRYSYVKLSF REHGQIEFQR
     RLAEELTQRR WERLSASASP SMQMNKGPQT GRIKAVGIVG IERKLEEKRK ETDKNISEAF
     EDLSKLMEKA KEMVELSKSI ATKIKDKQGD ISEDETIRFK SYLLSMGIAN PVTRETHGSG
     THYHMQLAKQ LATMLQAPLE ERGGIMSLTE VYCLVNRARG MELLSPEDLV NACKMLESLK
     LPIRLRVFDS GVMVIEHQSH NEEEMVASAL ETVSEKGSLT SEEFAKIVGM SVLLAKERLL
     LAENMGHLCR DDSVEGLRFY PNLFLTQS