ID   VPS37_DICDI             Reviewed;         333 AA.
AC   Q55DV8;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Vacuolar protein sorting-associated protein 37;
DE   AltName: Full=ESCRT-I complex subunit VPS37;
GN   Name=vps37; ORFNames=DDB_G0269510;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Component of the ESCRT-I complex, a regulator of vesicular
CC       trafficking process. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ESCRT-I complex (endosomal sorting complex
CC       required for transport I). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endosome {ECO:0000250}.
CC       Late endosome membrane {ECO:0000250}; Peripheral membrane protein
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the VPS37 family. {ECO:0000305}.
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DR   EMBL; AAFI02000005; EAL72105.1; -; Genomic_DNA.
DR   RefSeq; XP_646023.1; XM_640931.1.
DR   AlphaFoldDB; Q55DV8; -.
DR   SMR; Q55DV8; -.
DR   STRING; 44689.DDB0234024; -.
DR   PaxDb; Q55DV8; -.
DR   EnsemblProtists; EAL72105; EAL72105; DDB_G0269510.
DR   GeneID; 8616971; -.
DR   KEGG; ddi:DDB_G0269510; -.
DR   dictyBase; DDB_G0269510; vps37.
DR   eggNOG; KOG3270; Eukaryota.
DR   HOGENOM; CLU_835280_0_0_1; -.
DR   InParanoid; Q55DV8; -.
DR   OMA; HIKECLR; -.
DR   Reactome; R-DDI-917729; Endosomal Sorting Complex Required For Transport (ESCRT).
DR   PRO; PR:Q55DV8; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0000813; C:ESCRT I complex; ISS:dictyBase.
DR   GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006612; P:protein targeting to membrane; IBA:GO_Central.
DR   GO; GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.
DR   GO; GO:0043162; P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IBA:GO_Central.
DR   Gene3D; 1.10.287.660; -; 1.
DR   InterPro; IPR037202; ESCRT_assembly_dom.
DR   InterPro; IPR029012; Helix_hairpin_bin_sf.
DR   InterPro; IPR009851; Mod_r.
DR   Pfam; PF07200; Mod_r; 1.
DR   SUPFAM; SSF140111; SSF140111; 1.
DR   PROSITE; PS51314; VPS37_C; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Endosome; Membrane; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..333
FT                   /note="Vacuolar protein sorting-associated protein 37"
FT                   /id="PRO_0000367436"
FT   DOMAIN          256..333
FT                   /note="VPS37 C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00646"
FT   REGION          116..176
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        116..137
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        146..173
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   333 AA;  38784 MW;  84F761F6957B8261 CRC64;
     MSKPDLNSLS IKMKQINLLK ERFSHTIEVV KDSTFKIPFL NVHLLISLPV NFPNSPPAYF
     LEILQTHQPV SLPPNYQWTQ ISNLASVTVH IMEPFIKDSR ILETLIEQVK RSQAMQQQQQ
     QQQQQQRNQQ AQQQYSPPPP YKDQPINKQP AQQQPQPVQQ KPQQQQNGTN KIPMIPTEFP
     ELKSKSVEEL EELLKNEDSL NAFIYSYDEV SELSNRKSKL LSENERLTKI TDPLPNDIND
     LSANLMTSKQ KLEELKRKQE QLQQKKNSIA DKYSQQNLLE ILNDSISDLE SESDNIVHSF
     LEGNLELKEF KKQFKEKRSS YHSKCANKDL FFK